Siegel RL, Miller KD, Fuchs HE et al (2021) Cancer statistics, 2021. CA Cancer J Clin 71:7–33
Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87–108
Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68:7–30
Nagase S, Ohta T, Takahashi F et al (2022) Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology. Annual Patient Report for 2018 and Annual Treatment Report for 2013. J Obstet Res Gynaecol 48:541–552
Morice P, Leary A, Creutzberg C et al (2016) Endometrial cancer. Lancet 387:1094–1108
Wada M, Yamagami W. (2024) Immunotherapy for endometrial cancer. Int J Clin Oncol Online ahead of print.
Cancer Genome Atlas Research Network, Kandoth C, Schultz N et al (2013) Integrated genomic characterization of endometrial carcinoma. Nature 497:67–73
Kommoss S, McConechy MK, Kommoss F et al (2018) Final validation of the promise molecular classifier for endometrial carcinoma in a large population-based case series. Ann Oncol 29:1180–1188
Article CAS PubMed Google Scholar
Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 331:1565–1570
Article CAS PubMed Google Scholar
Yaguchi T, Kawakami Y (2016) Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation. Int Immunol 28:393–309
Article CAS PubMed PubMed Central Google Scholar
Peng H, He X, Wang Q (2022) Immune checkpoint blockades in gynecological cancers: a review of clinical trials. Acta Obstet Gynecol Scand 101:941–951
Article CAS PubMed PubMed Central Google Scholar
Taube JM, Klein A, Brahmer JR et al (2014) Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 20:5064–5074
Article CAS PubMed PubMed Central Google Scholar
De Felice F, Marchetti C, Tombolini V et al (2019) Immune check-point in endometrial cancer. Int J Clin Oncol 24:910–916
Patel SP, Kurzrock R (2015) PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol Cancer Ther 14:847–856
Article CAS PubMed Google Scholar
Le DT, Uram JN, Wang H et al (2015) PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372:2509–2520
Article CAS PubMed PubMed Central Google Scholar
Dudley JC, Lin MT, Le DT et al (2016) Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res 22:813–820
Article CAS PubMed Google Scholar
Mishima S, Taniguchi H, Akagi K et al (2020) Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology First Edition. Int J Clin Oncol 25:217–239
Article CAS PubMed Google Scholar
Yarchoan M, Hopkins A, Jaffee EM (2017) Tumor mutational burden and response rate to PD-1 inhibition. N Engl J Med 377:2500–2501
Article PubMed PubMed Central Google Scholar
Vanderwalde A, Spetzler D, Xiao N et al (2018) Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients. Cancer Med 7:746–756
Article CAS PubMed PubMed Central Google Scholar
Postow MA, Callahan MK, Wolchok JD (2015) Immune checkpoint blockade in cancer therapy. J Clin Oncol 33:1974–1982
Article CAS PubMed PubMed Central Google Scholar
Marabelle A, Le DT, Ascierto PA et al (2020) Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study. J Clin Oncol 38:1–10
Article CAS PubMed Google Scholar
Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680
Article CAS PubMed Google Scholar
Le DT, Durham JN, Smith KN et al (2017) Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357:409–413
Article CAS PubMed PubMed Central Google Scholar
NCCN (2024) NCCN clinical practice guidelines in oncology, Uterine Neoplasms version 3. Available via https://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf Accessed Oct 2024
Taylor MH, Betts CB, Maloney L et al (2022) Safety and efficacy of pembrolizumab in combination with Acalabrutinib in advanced head and neck squamous cell carcinoma: phase 2 proof-of-concept study. Clin Cancer Res 28:903–914
Article CAS PubMed Google Scholar
Makker V, Colombo N, Casado Herráez A et al (2022) Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer. N Engl J Med 386:437–448
Article CAS PubMed PubMed Central Google Scholar
Makker V, Colombo N, Casado Herráez A et al (2023) Lenvatinib Plus Pembrolizumab in Previously Treated Advanced Endometrial Cancer: Updated Efficacy and Safety From the Randomized Phase III Study 309/KEYNOTE-775. Clin Oncol 41:2904–2910
Yonemori K, Yunokawa M, Ushijima K et al (2022) Lenvatinib plus pembrolizumab in Japanese patients with endometrial cancer: results from Study 309/KEYNOTE-775. Cancer Sci 113:3489–3497
Article CAS PubMed PubMed Central Google Scholar
Oaknin A, Pothuri B, Gilbert L et al (2023) Safety, efficacy, and biomarker analyses of dostarlimab in patients with endometrial cancer: interim results of the phase I GARNET study. Clin Cancer Res 29:4564–4574
Article CAS PubMed PubMed Central Google Scholar
Mirza MR, Chase DM, Slomovitz BM et al (2023) Dostarlimab for primary advanced or recurrent endometrial cancer. N Engl J Med 388:2145–2158
Article CAS PubMed Google Scholar
Mirza MR, Shahin MS, Powell MA et al (2023) Patient-reported outcomes (PROs) in patients (pts) with primary advanced or recurrent endometrial cancer (pA/rEC) treated with dostarlimab (D) plus carboplatin/paclitaxel (CP) compared with CP in the ENGOT-EN6/GOG3031/RUBY trial. J Clin Oncol 41:TSP5504
Eskander RN, Sill MW, Beffa L et al (2023) Pembrolizumab plus chemotherapy in advanced endometrial cancer. N Engl J Med 388:2159–2170
Article CAS PubMed PubMed Central Google Scholar
Westin SN, Moore K, Chon HS et al (2024) Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial. J Clin Oncol 42:283–299
Article CAS PubMed Google Scholar
Colombo N, Harano K, Hudson E et al (2024) Atezolizumab and chemotherapy for advanced or recurrent endometrial cancer (AtTEnd): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 25(9):1135–1146
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