Akyer SP, Karagur ER, Ata MT, Toprak EK, Donmez AC, Donmez BO (2023) Verbascoside inhibits/repairs the damage of LPS-induced inflammation by regulating apoptosis, oxidative stress, and bone remodeling. Curr Issues Mol Biol 45(11):8755–8766. https://www.mdpi.com/1467-3045/45/11/550

Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci 90(17):7915–7922. https://doi.org/10.1073/pnas.90.17.7915

An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, Liu M, Guo W, Yu L (2019) Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis. Faseb j 33(11):12515–12527. https://doi.org/10.1096/fj.201802805RR

Article  PubMed  PubMed Central  Google Scholar 

Awuchi C (2019) Proximate composition and functional properties of different grain flour composites for industrial applications. Int J Food Sci 2:43–64. https://doi.org/10.47604/ijf.1010

Benzie IFF, Devaki M (2018) The ferric reducing/antioxidant power (FRAP) assay for non-enzymatic antioxidant capacity: concepts, procedures, limitations and applications. In measurement of antioxidant activity & capacity (pp. 77–106). https://doi.org/10.1002/9781119135388.ch5

Bibi Sadeer N, Montesano D, Albrizio S, Zengin G, Mahomoodally MF (2020) The versatility of antioxidant assays in food science and safety—chemistry, applications, strengths, and limitations. Antioxidants, 9(8):709. https://www.mdpi.com/2076-3921/9/8/709

Boyce BF, Xiu Y, Li J, Xing L, Yao Z (2015) NF-κB-mediated regulation of osteoclastogenesis. Endocrinol Metab (Seoul) 30(1):35–44. https://doi.org/10.3803/EnM.2015.30.1.35

Article  PubMed  Google Scholar 

Brown JP (2021) Long-term treatment of postmenopausal osteoporosis. Endocrinol Metab (Seoul) 36(3):544–552. https://doi.org/10.3803/EnM.2021.301

Article  PubMed  Google Scholar 

Carletti A, Cardoso C, Lobo-Arteaga J, Sales S, Juliao D, Ferreira I, Chainho P, Dionísio MA, Gaudêncio MJ, Afonso C, Lourenço H, Cancela ML, Bandarra NM, Gavaia PJ (2022) Antioxidant and anti-inflammatory extracts from sea cucumbers and tunicates induce a pro-osteogenic effect in Zebrafish Larvae [Original Research]. Front Nutrit. https://doi.org/10.3389/fnut.2022.888360

Article  Google Scholar 

Chaiyasut C, Sivamaruthi B, Pengkumsri N, Sirilun S, Peerajan S, Chaiyasut K, Kesika P (2016) Anthocyanin profile and its antioxidant activity of widely used fruits, vegetables, and flowers in Thailand. 9:218–224. https://doi.org/10.22159/ajpcr.2016.v9i6.14245

Chatree K, Sriboonaied P, Phetkong C, Wattananit W, Chanchao C, Charoenpanich A (2023) Distinctions in bone matrix nanostructure, composition, and formation between osteoblast-like cells, MG-63, and human mesenchymal stem cells, UE7T-13. Heliyon 9(5):e15556. https://doi.org/10.1016/j.heliyon.2023.e15556

Chaturvedi R, Singha PK, Dey S (2013) Water soluble bioactives of nacre mediate antioxidant activity and osteoblast differentiation. PLoS One 8(12):e84584. https://doi.org/10.1371/journal.pone.0084584

Article  PubMed  PubMed Central  Google Scholar 

Dvorakova J, Wiesnerova L, Chocholata P, Kulda V, Landsmann L, Cedikova M, Kripnerova M, Eberlova L, Babuska V (2023) Human cells with osteogenic potential in bone tissue research. Biomed Eng Online 22(1):33. https://doi.org/10.1186/s12938-023-01096-w

Article  PubMed  PubMed Central  Google Scholar 

Franková H, Musilová J, Árvay J, Šnirc M, Jančo I, Lidiková J, Vollmannová A (2022. Changes in antioxidant properties and phenolics in sweet potatoes (Ipomoea batatas L.) due to heat treatments. Molecules, 27(6):1884. https://www.mdpi.com/1420-3049/27/6/1884

Gilbert L, He X, Farmer P, Boden S, Kozlowski M, Rubin J, Nanes MS (2000) Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology 141(11):3956–3964. https://doi.org/10.1210/endo.141.11.7739

Article  PubMed  Google Scholar 

Hamada T, Duarte S, Tsuchihashi S, Busuttil RW, Coito AJ (2009) Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol 174(6):2265–2277. https://doi.org/10.2353/ajpath.2009.080872

Article  PubMed  PubMed Central  Google Scholar 

Han J, Yang K, An J, Jiang N, Fu S, Tang X (2022) The role of NRF2 in bone metabolism - friend or foe? Front Endocrinol (Lausanne) 13:813057. https://doi.org/10.3389/fendo.2022.813057

Article  PubMed  Google Scholar 

Hao X, Guan R, Huang H, Yang K, Wang L, Wu Y (2021) Anti-inflammatory activity of cyanidin-3-O-glucoside and cyanidin-3-O-glucoside liposomes in THP-1 macrophages. Food Sci Nutrit 9(12):6480–6491. https://doi.org/10.1002/fsn3.2554

Article  Google Scholar 

Hong Y, Boiti A, Vallone D, Foulkes NS (2024) Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution. Antioxidants 13(3):312. https://www.mdpi.com/2076-3921/13/3/312

Hu B, Chen L, Chen Y, Zhang Z, Wang X, Zhou B (2021) Cyanidin-3-glucoside regulates osteoblast differentiation via the ERK1/2 signaling pathway. ACS Omega 6(7):4759–4766. https://doi.org/10.1021/acsomega.0c05603

Article  PubMed  PubMed Central  Google Scholar 

Hyeon S, Yang Y, Jeong W (2013) Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. Free Radical Biol Medicine 65. https://doi.org/10.1016/j.freeradbiomed.2013.08.005

Iantomasi T, Romagnoli C, Palmini G, Donati S, Falsetti I, Miglietta F, Aurilia C, Marini F, Giusti F, Brandi M (2023) Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs. Int J Mol Sci 24:3772. https://doi.org/10.3390/ijms24043772

Article  PubMed  PubMed Central  Google Scholar 

Idowu A (2014) Development, nutrient composition and sensory properties of biscuits produced from composite flour of wheat and African Yam Bean. British J Appl Sci Technol 4:1925–1933. https://doi.org/10.9734/BJAST/2014/7183

Article  Google Scholar 

Ji H, Zhang H, Li H, Li Y (2015) Analysis on the nutrition composition and antioxidant activity of different types of sweet potato cultivars. Food Nutr Sci 06:161–167. https://doi.org/10.4236/fns.2015.61017

Article  Google Scholar 

Khonthun C, Khoothiam K, Chumphukam O, Thongboontho R, Oonlao P, Nuntaboon P, Phromnoi K (2023) Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts in Northern Thailand. Funct Foods Health Dis 13:52. https://doi.org/10.31989/ffhd.v13i2.1070

Kim HW, Kim JB, Cho SM, Chung MN, Lee YM, Chu SM, Che JH, Kim SN, Kim SY, Cho YS, Kim JH, Park HJ, Lee DJ (2012) Anthocyanin changes in the Korean purple-fleshed sweet potato, Shinzami, as affected by steaming and baking. Food Chem 130(4):966–972. https://doi.org/10.1016/j.foodchem.2011.08.031

Article  Google Scholar 

Lee SE, Park YS (2021) The emerging roles of antioxidant enzymes by dietary phytochemicals in vascular diseases. Life (Basel). https://doi.org/10.3390/life11030199

Article  PubMed  PubMed Central  Google Scholar 

Lee J, Durst R, Wrolstad R (2005) Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: Collaborative Study. J AOAC Int 88:1269–1278

Article  PubMed  Google Scholar 

Li Q, Tian C, Liu X, Li D, Liu H (2023) Anti-inflammatory and antioxidant traditional Chinese Medicine in treatment and prevention of osteoporosis [Review]. Front Pharmacol. https://doi.org/10.3389/fphar.2023.1203767

Article  PubMed  PubMed Central  Google Scholar 

Li X, Yu L, Xie Y, Li C, Fang Z, Hu B, Wang C, Chen S, Wu W, Li X, Zeng Z, Liu Y (2023) Effect of different cooking methods on the nutrient, and subsequent bioaccessibility and biological activities in Boletus auripes. Food Chem 405:134358. https://doi.org/10.1016/j.foodchem.2022.134358

Article  PubMed  Google Scholar 

Makori S, Mu TH, Sun H-N (2020) Total polyphenol content, antioxidant activity, and individual phenolic composition of different edible parts of 4 sweet potato cultivars. Nat Prod Commun. https://doi.org/10.1177/1934578X20936931

Article  Google Scholar 

Mao W, Huang G, Chen H, Xu L, Qin S, Li A (2021) Research Progress of the role of anthocyanins on bone regeneration [Review]. Front Pharmacol. https://doi.org/10.3389/fphar.2021.773660

Article  PubMed  PubMed Central  Google Scholar 

Min SW, Ryu SN, Kim DH (2010) Anti-inflammatory effects of black rice, cyanidin-3-O-beta-D-glycoside, and its metabolites, cyanidin and protocatechuic acid. Int Immunopharmacol 10(8):959–966. https://doi.org/10.1016/j.intimp.2010.05.009

Article  PubMed  Google Scholar 

Montilla EC, Hillebrand S, Butschbach D, Baldermann S, Watanabe N, Winterhalter P (2010) Preparative isolation of anthocyanins from Japanese purple sweet potato (Ipomoea batatas L.) varieties by high-speed countercurrent chromatography. J Agric Food Chem 58(18):9899–9904. https://doi.org/10.1021/jf101898j

Article  PubMed  Google Scholar 

Muniandy K, Gothai S, Badran KMH, Suresh Kumar S, Esa NM, Arulselvan P (2018) Suppression of proinflammatory cytokines and mediators in LPS-induced RAW 264.7 macrophages by Stem extract of alternanthera sessilis via the inhibition of the NF-κB pathway. J Immunol Res. https://doi.org/10.1155/2018/3430684

Article  PubMed  PubMed Central  Google Scholar 

Ngailo S, Shimelis H, Sibiya J, Mtunda K (2013) Sweet potato breeding for resistance to sweet potato virus disease and improved yield: progresses and challenges. Afr J Agric Res 8:3202–3215. https://doi.org/10.5897/AJAR12.1991

Article  Google Scholar 

Pacifici R (2013) Role of T cells in the modulation of PTH action: physiological and clinical significance. Endocrine 44(3):576–582. https://doi.org/10.1007/s12020-013-9960-8

Article  PubMed  Google Scholar 

Park KH, Gu DR, So HS, Kim KJ, Lee SH (2015) Dual role of cyanidin-3-glucoside on the differentiation of bone cells. J Dent Res 94(12):1676–1683. https://doi.org/10.1177/0022034515604620

Article  PubMed  Google Scholar 

Pattananandecha T, Apichai S, Julsrigival, J, Ungsurungsie M, Samuhasaneetoo S, Chulasiri P, Kwankhao P, Pitiporn S, Ogata F, Kawasaki N, Saenjum C (2021) Antioxidant activity and anti-photoaging effects on UVA-irradiated human fibroblasts of rosmarinic acid enriched extract prepared from Thunbergia laurifolia leaves. Plants 10(8):1648. https://www.mdpi.com/2223-7747/10/8/1648

Pérez M, Dominguez-López I, Lamuela-Raventós RM (2023) The chemistry behind the folin-ciocalteu method for the estimation of (Poly)phenol content in