Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet. 2019;394:1949–64.

Article  CAS  PubMed  Google Scholar 

Kellum JA, Prowle JR. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018;14:217–30.

Article  PubMed  Google Scholar 

Takaori K, Nakamura J, Yamamoto S, Nakata H, Sato Y, Takase M, et al. Severity and frequency of proximal tubule injury determines renal prognosis. J Am Soc Nephrol. 2016;27:2393–406.

Article  PubMed  Google Scholar 

Berger K, Bangen JM, Hammerich L, Liedtke C, Floege J, Smeets B, et al. Origin of regenerating tubular cells after acute kidney injury. Proc Natl Acad Sci USA. 2014;111:1533–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kusaba T, Lalli M, Kramann R, Kobayashi A, Humphreys BD. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci USA. 2014;111:1527–32.

Article  CAS  PubMed  Google Scholar 

Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008;2:284–91.

Article  CAS  PubMed  Google Scholar 

Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol. 2003;14:S55–61.

Article  PubMed  Google Scholar 

Chang-Panesso M, Kadyrov FF, Lalli M, Wu H, Ikeda S, Kefaloyianni E, et al. FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury. J Clin Invest. 2019;129:5501–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humphreys BD, Czerniak S, DiRocco DP, Hasnain W, Cheema R, Bonventre JV. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci USA. 2011;108:9226–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K. Sox9-positive progenitor cells play a key role in renal tubule epithelial regeneration in mice. Cell Rep. 2016;14:861–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar S, Liu J, Pang P, Krautzberger AM, Reginensi A, Akiyama H, et al. Sox9 activation highlights a cellular pathway of renal repair in the acutely injured mammalian kidney. Cell Rep. 2015;12:1325–38.

Article  CAS  PubMed  Google Scholar 

Nie H, Zhao Z, Zhou D, Li D, Wang Y, Ma Y, et al. Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors. Cell Prolif. 2023;56:e13394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Q, Wang Y, Zhang T, Zuo W. Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy. Life Sci. 2018;193:104–9.

Article  CAS  PubMed  Google Scholar 

Chen JW, Huang MJ, Chen XN, Wu LL, Li QG, Hong Q, et al. Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9+ renal tubular cells. Theranostics. 2022;12:5434–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JY, Silvaroli JA, Martinez GV, Bisunke B, Luna Ramirez AV, Jayne LA, et al. Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury. Kidney Int. 2023;103:1093–104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JY, Bai Y, Jayne LA, Hector RD, Persaud AK, Ong SS, et al. A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nat Commun. 2020;11:1924.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dunwoodie SL. The role of hypoxia in development of the mammalian embryo. Dev Cell. 2009;17:755–73.

Article  CAS  PubMed  Google Scholar 

Little MH, Kairath P. Does renal repair recapitulate kidney development? J Am Soc Nephrol. 2017;28:34–46.

Article  CAS  PubMed  Google Scholar 

Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, et al. Hypoxia induces heart regeneration in adult mice. Nature. 2017;541:222–7.

Article  CAS  PubMed  Google Scholar 

Jopling C, Sune G, Faucherre A, Fabregat C, Izpisua Belmonte JC. Hypoxia induces myocardial regeneration in zebrafish. Circulation. 2012;126:3017–27.

Article  PubMed  Google Scholar 

Cho Y, Shin JE, Ewan EE, Oh YM, Pita-Thomas W, Cavalli V. Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1 alpha. Neuron. 2015;88:720–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McBrearty B, Clark L, Zhang X, Blankenhorn E, Heber-Katz E. Genetic analysis of a mammalian wound-healing trait. Proc Natl Acad Sci USA. 1998;95:11792–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Strehin I, Bedelbaeva K, Gourevitch D, Clark L, Leferovich J, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015;7:290ra92.

Article  PubMed  PubMed Central  Google Scholar 

Semenza GL. HIF-1, O2, and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 2001;107:1–3.

Article  CAS  PubMed  Google Scholar 

Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol. 2001;13:167–71.

Article  CAS  PubMed  Google Scholar 

Moslehi J, Rathmell WK. The 2019 Nobel Prize honors fundamental discoveries in hypoxia response. J Clin Invest. 2020;130:4–6.

Article  PubMed  Google Scholar 

Kupferschmidt K. Cellular oxygen sensor system earns Nobel for trio. Science. 2019;366:167.

Article  CAS  PubMed  Google Scholar 

Ledford H, Callaway E. Biologists who decoded how cells sense oxygen win medicine Nobel. Nature. 2019;574:161–2.

Article  CAS  PubMed  Google Scholar 

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J. 2003;22:4082–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DeFrates K, Franco D, Heber-Katz E, Messersmith P. Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling. Biomaterials. 2021;269:120646.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Locatelli F, Del Vecchio L. Hypoxia-inducible factor-prolyl hydroxyl domain inhibitors: from theoretical superiority to clinical noninferiority compared with current ESAs? J Am Soc Nephrology: JASN. 2022;33:1966–79.