Lee JM, Hammarén HM, Savitski MM, Baek SH. Control of protein stability by post-translational modifications. Nat Commun. 2023;14:201.
Article CAS PubMed PubMed Central Google Scholar
Cappadocia L, Lima CD. Ubiquitin-like protein conjugation: structures, chemistry, and mechanism. Chem Rev. 2018;118:889–918.
Article CAS PubMed Google Scholar
Wang X, Lv X, Ma J, Xu G. UFMylation: an integral post-translational modification for the regulation of proteostasis and cellular functions. Pharmacol Ther. 2024;260:108680.
Article CAS PubMed Google Scholar
Ha BH, Ahn HC, Kang SH, Tanaka K, Chung CH, Kim EE. Structural basis for Ufm1 processing by UfSP1. J Biol Chem. 2008;283:14893–900.
Article CAS PubMed Google Scholar
Millrine D, Cummings T, Matthews SP, Peter JJ, Magnussen HM, Lange SM, et al. Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation. Cell Rep. 2022;40:111168.
Article CAS PubMed PubMed Central Google Scholar
Zhou X, Mahdizadeh SJ, Le Gallo M, Eriksson LA, Chevet E, Lafont E. UFMylation: a ubiquitin-like modification. Trends Biochem Sci. 2024;49:52–67.
Article CAS PubMed Google Scholar
Komatsu M, Inada T, Noda NN. The UFM1 system: working principles, cellular functions, and pathophysiology. Mol Cell. 2024;84:156–69.
Article CAS PubMed Google Scholar
Peter JJ, Magnussen HM, DaRosa PA, Millrine D, Matthews SP, Lamoliatte F, et al. A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation. EMBO J. 2022;41:e111015.
Article CAS PubMed PubMed Central Google Scholar
Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, et al. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Mol Cell. 2014;56:261–74.
Article CAS PubMed Google Scholar
Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, et al. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J. 2004;23:1977–86.
Article CAS PubMed PubMed Central Google Scholar
Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev AA, et al. An N-terminal extension to UBA5 adenylation domain boosts UFM1 activation: Isoform-specific differences in ubiquitin-like protein activation. J Mol Biol. 2019;431:463–78.
Article CAS PubMed Google Scholar
Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, et al. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem. 2007;282:5256–62.
Article CAS PubMed Google Scholar
Sasakawa H, Sakata E, Yamaguchi Y, Komatsu M, Tatsumi K, Kominami E, et al. Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1. Biochem Biophys Res Commun. 2006;343:21–6.
Article CAS PubMed Google Scholar
Liang Q, Jin Y, Xu S, Zhou J, Mao J, Ma X, et al. Human UFSP1 translated from an upstream near-cognate initiation codon functions as an active UFM1-specific protease. J Biol Chem. 2022;298:102016.
Article CAS PubMed PubMed Central Google Scholar
Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, et al. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem. 2011;286:10248–57.
Article CAS PubMed PubMed Central Google Scholar
Gavin JM, Hoar K, Xu Q, Ma J, Lin Y, Chen J, et al. Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway. J Biol Chem. 2014;289:22648–58.
Article CAS PubMed PubMed Central Google Scholar
Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, et al. Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and UFMylation. J Biol Chem. 2016;291:9025–41.
Article CAS PubMed PubMed Central Google Scholar
Oweis W, Padala P, Hassouna F, Cohen-Kfir E, Gibbs DR, Todd EA, et al. Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 complex. Cell Rep. 2016;16:3113–20.
Article CAS PubMed Google Scholar
Kumar M, Padala P, Fahoum J, Hassouna F, Tsaban T, Zoltsman G, et al. Structural basis for UFM1 transfer from UBA5 to UFC1. Nat Commun. 2021;12:5708.
Article CAS PubMed PubMed Central Google Scholar
Gerakis Y, Quintero M, Li H, Hetz C. The UFMylation system in proteostasis and beyond. Trends Cell Biol. 2019;29:974–86.
Article CAS PubMed PubMed Central Google Scholar
Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, et al. A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem. 2010;285:5417–27.
Article CAS PubMed Google Scholar
Banerjee S, Varga JK, Kumar M, Zoltsman G, Rotem-Bamberger S, Cohen-Kfir E, et al. Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in UFMylation. EMBO Rep. 2023;24:e56920.
Article CAS PubMed PubMed Central Google Scholar
Wu J, Lei G, Mei M, Tang Y, Li H. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappab signaling. J Biol Chem. 2010;285:15126–36.
Article CAS PubMed PubMed Central Google Scholar
Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan E, Sanchez de Medina Hernandez V, et al. A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress. Elife. 2020;9:e58396.
Zhang M, Zhu X, Zhang Y, Cai Y, Chen J, Sivaprakasam S, et al. RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis. Cell Death Differ. 2015;22:1922–34.
Article CAS PubMed PubMed Central Google Scholar
Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, et al. A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-resident UFMylation. Cell. 2020;180:1160–77.e20.
Article CAS PubMed PubMed Central Google Scholar
Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, et al. The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity. Cell. 2017;169:1051–65.e18.
Article CAS PubMed PubMed Central Google Scholar
Walczak CP, Leto DE, Zhang L, Riepe C, Muller RY, DaRosa PA, et al. Ribosomal protein RPL26 is the principal target of UFMylation. Proc Natl Acad Sci USA. 2019;116:1299–308.
Article CAS PubMed PubMed Central Google Scholar
Wang L, Xu Y, Rogers H, Saidi L, Noguchi CT, Li H, et al. UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis. Cell Res. 2020;30:5–20.
Article CAS PubMed Google Scholar
DaRosa PA, Penchev I, Gumbin SC, Scavone F, Wąchalska M, Paulo JA, et al. UFM1 E3 ligase promotes recycling of 60S ribosomal
留言 (0)