Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation

Shou Y, Yang L, Yang Y, Xu J. Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. Cell Death Dis. 2021;12:1009.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Blauvelt A, Chiricozzi A. The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis. Clin Rev Allergy Immunol. 2018;55:379–90.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dobrică EC, Cozma MA, Găman MA, Voiculescu VM, Găman AM. The involvement of oxidative stress in psoriasis: a systematic review. Antioxidants. 2022;11:2.

Ogawa T, Ishitsuka Y. The role of KEAP1-NRF2 system in atopic dermatitis and psoriasis. Antioxidants. 2022;11:7.

Geertsema S, Bourgonje AR, Fagundes RR, Gacesa R, Weersma RK, Van Goor H, et al. The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease. Trends Mol Med. 2023;29:830–42.

Article  PubMed  Google Scholar 

Sies H, Berndt C, Jones DP. Oxidative stress. Annu Rev Biochem. 2017;86:715–48.

Article  PubMed  CAS  Google Scholar 

Armstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA. 2020;323:1945–60.

Article  PubMed  CAS  Google Scholar 

Li T, Gao S, Han W, Gao Z, Wei Y, Wu G, et al. Potential effects and mechanisms of Chinese herbal medicine in the treatment of psoriasis. J Ethnopharmacol. 2022;294:115275.

Article  PubMed  Google Scholar 

Xiao H, Sun X, Lin Z, Yang Y, Zhang M, Xu Z, et al. Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism. Acta Pharm Sin B. 2022;12:2887–904.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang X, Yang Q, Yang F, Gong J, Han H, Yang L, et al. Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice. J Ethnopharmacol. 2016;194:63–71.

Article  PubMed  CAS  Google Scholar 

Li X, Zhang Y, Jin Q, Xia KL, Jiang M, Cui BW, et al. Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis. Br J Pharmacol. 2018;175:1451–70.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen F, Xie L, Kang R, Deng R, Xi Z, Sun D, et al. Gentiopicroside inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and JNK signaling pathways. Biomed Pharmacother. 2018;100:142–6.

Article  PubMed  CAS  Google Scholar 

Zhao L, Ye J, Wu GT, Peng XJ, Xia PF, Ren Y. Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte. J Ethnopharmacol. 2015;172:100–7.

Article  PubMed  CAS  Google Scholar 

Almukainzi M, El-Masry TA, Negm WA, Elekhnawy E, Saleh A, Sayed AE, et al. Co-delivery of gentiopicroside and thymoquinone using electrospun m-PEG/PVP nanofibers: In-vitro and In vivo studies for antibacterial wound dressing in diabetic rats. Int J Pharmacol. 2022;625:122106.

Article  CAS  Google Scholar 

Zhao K, Pu S, Sun L, Zhou D. Gentiopicroside-loaded chitosan nanoparticles inhibit tnf-alpha-induced proliferation and inflammatory response in HaCaT keratinocytes and ameliorate imiquimod-induced dermatitis lesions in mice. Int J Nanomed. 2023;18:3781–800.

Article  CAS  Google Scholar 

Wan Z, Li H, Wu X, Zhao H, Wang R, Li M, et al. Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats. Life Sci. 2021;265:118689.

Article  PubMed  CAS  Google Scholar 

Zhang L-J, Adase CA, Li F. Isolation and culture of primary mouse keratinocytes from neonatal and adult mouse skin. J Vis Exp. 2017;125:56027.

Google Scholar 

Li H, Zhang X, Xiang C, Feng C, Fan C, Liu M, et al. Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation. J Adv Res. 2021;33:241–51.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Johnston HE, Yadav K, Kirkpatrick JM, Biggs GS, Oxley D, Kramer HB, et al. Solvent precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads. Anal Chem. 2022;94:10320–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou X, Chen Y, Cui L, Shi Y, Guo C. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 2022;13:81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brunner PM, Guttman-Yassky E, Leung DY. The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies. J Allergy Clin Immunol. 2017;139:S65–s76.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bai Y, Wu H, Zheng L, Xie Y, Liu F, Wan Y, et al. Mechanisms of Yajieshaba in the treatment of liver fibrosis through the Keap1-Nrf2 signaling pathway. Front Pharmacol. 2023;14:1124015.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ma C, Gu C, Lian P, Wazir J, Lu R, Ruan B, et al. Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 pathway activation and attenuating inflammatory signaling. Cell Death Dis. 2023;14:11.

Jiang T, Harder B, Rojo De La Vega M, Wong PK, Chapman E, Zhang DD. p62 links autophagy and Nrf2 signaling. Free Radic Biol Med. 2015;88:199–204.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang Q, Zhou X, Yang L, Luo M, Han L, Lu Y, et al. Gentiopicroside (GENT) protects against sepsis induced by lipopolysaccharide (LPS) through the NF-kappaB signaling pathway. Ann Transl Med. 2019;7:731.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Segre JA. Epidermal barrier formation and recovery in skin disorders. J Clin Invest. 2006;116:1150–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao J, Chen F, Fang H, Mi J, Qi Q, Yang M. Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice. Biol Res. 2020;53:48.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, et al. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci USA. 2013;110:19537–42.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qiu M, Xiao F, Wang T, Piao S, Zhao W, Shao S, et al. Protective effect of Hedansanqi Tiaozhi Tang against non-alcoholic fatty liver disease in vitro and in vivo through activating Nrf2/HO-1 antioxidant signaling pathway. Phytomedicine. 2020;67:153140.

Article  PubMed  CAS  Google Scholar 

Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol. 2010;80:1895–903.

Article  PubMed  CAS  Google Scholar 

Ishitsuka Y, Ogawa T, Roop D. The KEAP1/NRF2 signaling pathway in keratinization. Antioxidants. 2020;9:8.

Gu Y, Han J, Jiang C, Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020;59:101036.

Article  PubMed  CAS  Google Scholar 

留言 (0)

沒有登入
gif