Agarwal K, Mukherjee A, Sen S (1994) Etoposide (VP-16): cytogenetic studies in mice. Environ Mol Mutagen 23(3):190–193

Article  PubMed  Google Scholar 

Anfray C, Mainini F, Andón FT (2020) Nanoparticles for immunotherapy. Front Nanosci 16:265–306

Article  Google Scholar 

Aston WJ, Hope DE, Nowak AK, Robinson BW, Lake RA, Lesterhuis WJ (2017) A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice. BMC Cancer 17:1–10

Article  Google Scholar 

Bade BC, Dela Cruz CS (2020) Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 41(1):1–24

Article  PubMed  Google Scholar 

Baker S, Dahele M, Lagerwaard FJ, Senan S (2016) A critical review of recent developments in radiotherapy for non-small cell lung cancer. Rad Oncol 11:1–14

Google Scholar 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics (2022) GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229-263

Bukowski K, Kciuk M, Kontek R (2020) Mechanisms of multidrug resistance in cancer chemotherapy. Int J Mol Sci 21(9):3233. https://doi.org/10.3390/ijms21093233

Article  PubMed  PubMed Central  Google Scholar 

Carneiro BA, El-Deiry WS (2020) Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol 17(7):395–417

Article  PubMed  PubMed Central  Google Scholar 

Carvalho GC, Marena GD, Karnopp JCF, Jorge J, Sábio RM, Martines MAU, Bauab TM, Chorilli M (2022) Cetyltrimethylammonium bromide in the synthesis of mesoporous silica nanoparticles: General aspects and in vitro toxicity. Adv Colloid Interface Sci. 307:102746. https://doi.org/10.1016/j.cis.2022.102746

Article  PubMed  Google Scholar 

Chen JF, Ding HM, Wang JX, Shao L (2004) Preparation and characterization of porous hollow silica nanoparticles for drug delivery application. Biomaterials 25(4):723–727

Article  PubMed  Google Scholar 

Chen AM, Zhang M, Wei D, Stueber D, Taratula O, Minko T, He H (2009) Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug resistant cancer cells. Small (Weinheim an der Bergstrasse, Germany) 5(23):2673

Article  PubMed  Google Scholar 

Clegg A, Scott DA, Hewitson P, Sidhu M, Waugh N (2002) Clinical and cost effectiveness of paclitaxel, docetaxel, gemcitabine, and vinorelbine in non-small cell lung cancer: a systematic review. Thorax 57(1):20–28

Article  PubMed  PubMed Central  Google Scholar 

Cordeiro RA, Mendonça PV, Coelho J, Faneca H (2022) Engineering silica-polymer hybrid nanosystems for dual drug and gene delivery. Biomat Adv 135:212742

Article  Google Scholar 

de la Harpe KM, Kondiah PPD, Choonara YE, Marimuthu T, du Toit LC, Pillay V (2019) The hemocompatibility of nanoparticles: a review of cell–nanoparticle interactions and hemostasis. Cells 8(10):1209

Article  PubMed  PubMed Central  Google Scholar 

De Silva L, Fu JY, Htar TT, Wan Kamal WHB, Kasbollah A, Muniyandy S, Chuah LH (2022) Biodistribution study of niosomes in tumor-implanted BALB/C mice using scintigraphic imaging. Front Pharmacol 12:778396

Article  PubMed  PubMed Central  Google Scholar 

de Wilt LH, Jansen G, Assaraf YG, van Meerloo J, Cloos J, Schimmer AD, Chan ET, Kirk CJ, Peters GJ, Kruyt FA (2012) Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer. Biochem Pharmacol 83(2):207–217

Article  PubMed  Google Scholar 

Deng L, Meng T, Chen L, Wei W, Wang P (2020) The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Trans Target Ther 5(1):11

Article  Google Scholar 

Dilnawaz F (2019) Multifunctional mesoporous silica nanoparticles for cancer therapy and imaging. Curr Med Chem 26(31):5745–5763

Article  PubMed  Google Scholar 

Dilnawaz F, Sahoo SK (2013) Enhanced accumulation of curcumin and temozolomide loaded magnetic nanoparticles executes profound cytotoxic effect in glioblastoma spheroid model. Eur J Pharm Biopharm. 85(3 Pt A):452–462

Article  PubMed  Google Scholar 

Dilnawaz F, Sahoo SK (2018) Augmented anticancer efficacy by si-RNA complexed drug-loaded mesoporous silica nanoparticles in lung cancer therapy. ACS Appl Nano Mater 1(2):730–740

Article  Google Scholar 

Djayanti K, Maharjan P, Cho KH, Jeong S, Kim MS, Shin MC, Min KA (2023) Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations. Int J Mol Sci. 24(7):6349. https://doi.org/10.3390/ijms24076349

Article  PubMed  PubMed Central  Google Scholar 

Evans BC, Nelson CE, Yu SS, Beavers KR, Kim AJ, Li H, Nelson HM, Giorgio TD, Duvall CL (2013) Ex vivo red blood cell hemolysis assay for the evaluation of pH-responsive endosomolytic agents for cytosolic delivery of biomacromolecular drugs. J Vis Exp 9(73):e50166. https://doi.org/10.3791/50166

Article  Google Scholar 

Fan Q, Wang Q, Cai R, Yuan H, Xu M (2020) The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer. Cell Mol Biol Lett 25:1–19

Article  PubMed  PubMed Central  Google Scholar 

Fukuda S, Pelus LM (2006) Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther 5:1087–1098

Article  PubMed  Google Scholar 

Fuld AD, Dragnev KH, Rigas JR (2010) Pemetrexed in advanced non-small-cell lung cancer. Exp Opinion Pharmacother 11(8):1387–1402

Article  Google Scholar 

Gisbert-Garzarán M, Vallet-Regí M (2020) Influence of the surface functionalization on the fate and performance of mesoporous silica nanoparticles. Nanomaterials 10(5):916

Article  PubMed  PubMed Central  Google Scholar 

Groen K, Van De Donk N, Stege CAM, Zweegman S, Nijhof IS (2019) Carfilzomib for relapsed and refractory multiple myeloma. Cancer Manag Res 11:2663–2675

Article  PubMed  PubMed Central  Google Scholar 

Guan J, Sun J, Sun F, Lou B, Zhang D, Mashayekhi V, He Z (2017) Hypoxia-induced tumor cell resistance is overcome by synergistic GAPDH-siRNA and chemotherapy co-delivered by long-circulating and cationic-interior liposomes. Nanoscale 9(26):9190–9201

Article  PubMed  Google Scholar 

Hájek R, Masszi T, Petrucci MT, Palumbo A, Rosiñol L, Nagler A, Pour L (2017) A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia 31(1):107–114

Article  PubMed  Google Scholar 

Igaz N, Bélteky P, Kovács D, Papp C, Rónavári A, Szabó D, Kiricsi M (2022) Functionalized mesoporous silica nanoparticles for drug-delivery to multidrug-resistant cancer cells. Int J Nanomed 17:3079–3096

Article  Google Scholar 

Jin H, Wang L, Bernards R (2023) Rational combinations of targeted cancer therapies: background, advances and challenges. Nat Rev Drug Discov 22(3):213–234

Article  PubMed  Google Scholar 

Jugdaohsingh R, Brown A, Dietzel M, Powell JJ (2013) High-aluminum-affinity silica is a nanoparticle that seeds secondary aluminosilicate formation. Plos One 8(12):e84397

Article  PubMed  PubMed Central  Google Scholar 

Kabashin AV, Timoshenko VY (2016) What Theranostic Applications Could Ultrapure Laser-Synthesized Si Nanoparticles have in Cancer? Nanomedicine 11(17):2247–2250. https://doi.org/10.2217/nnm-2016-0228

Article  PubMed  Google Scholar 

Kang M, Jordan V, Blenkiron C, Chamley LW (2021) Biodistribution of extracellular vesicles following administration into animals: a systematic review. J Extracell Ves 10(8):e12085

Article  Google Scholar 

Khan RZ, Badros A (2012) Role of carfilzomib in the treatment of multiple myeloma. Expert Rev Hematol 5:361–372

Article  PubMed  Google Scholar 

Kuhn DJ, Chen Q, Voorhees PM, Strader JS, Shenk KD, Sun CM, Chanan-Khan AA (2007) Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood J Am Soc Hematol 110(9):3281–3290

Google Scholar 

Leiter A, Veluswamy RR, Wisnivesky JP (2023) The global burden of lung cancer: current status and future trends. Nat Rev Clin Oncol 20:624–639

Article  PubMed  Google Scholar