Piché ME, Tchernof A, Després JP. Obesity phenotypes, diabetes, and Cardiovascular diseases. Circ Res. 2020;126(11):1477–500.

Article  PubMed  Google Scholar 

Love KM, Jahn LA, Hartline LM, Aylor KW, Liu Z. Impact of free fatty acids on vascular insulin responses across the arterial tree: a randomized crossover study. J Clin Endocrinol Metab. 2024;109(4):1041–50.

Article  PubMed  Google Scholar 

Nazarzadeh M, Bidel Z, Canoy D, Copland E, Wamil M, Majert J, et al. Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis. Lancet. 2021;398(10313):1803–10.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Association AD. 10. Cardiovascular Disease and Risk Management: standards of Care in Diabetes-2025. Diabetes Care. 2025;48(Supplement1):S207–38.

Google Scholar 

Barrett EJ, Wang H, Upchurch CT, Liu Z. Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. Am J Physiol Endocrinol Metab. 2011;301(2):E252–63.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu J, Liu Z. Muscle insulin resistance and the inflamed microvasculature: fire from within. Int J Mol Sci. 2019;20(3):562.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fu J, Yu MG, Li Q, Park K, King GL. Insulin’s actions on vascular tissues: physiological effects and pathophysiological contributions to vascular complications of diabetes. Mol Metab. 2021;52:101236.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Love KM, Barrett EJ, Malin SK, Reusch JEB, Regensteiner JG, Liu Z. Diabetes pathogenesis and management: the endothelium comes of age. J Mol Cell Biol. 2021;13(7):500–12.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012;15(5):635–45.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yazıcı D, Demir S, Sezer H. Insulin resistance, obesity, and lipotoxicity. Adv Exp Med Biol. 2024;1460:391–430.

Article  PubMed  Google Scholar 

Vessby B, Uusitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study. Diabetologia. 2001;44(3):312–9.

Article  PubMed  CAS  Google Scholar 

Yang W, Jiang W, Guo S. Regulation of macronutrients in insulin resistance and glucose homeostasis during type 2 diabetes Mellitus. Nutrients. 2023;15(21).

Zheng C, Liu Z. Vascular function, insulin action, and exercise: an intricate interplay. Trends Endocrinol Metabolism. 2015;26(6):297–304.

Article  CAS  Google Scholar 

Malin SK, Liu Z, Barrett EJ, Weltman A. Exercise resistance across the prediabetes phenotypes: impact on insulin sensitivity and substrate metabolism. Reviews Endocr Metabolic Disorders. 2016;17(1):81–90.

Article  CAS  Google Scholar 

Yin M, Chen Z, Nassis GP, Liu H, Li H, Deng J, et al. Chronic high-intensity interval training and moderate-intensity continuous training are both effective in increasing maximum fat oxidation during exercise in overweight and obese adults: a meta-analysis. J Exerc Sci Fit. 2023;21(4):354–65.

Article  PubMed  PubMed Central  Google Scholar 

Magkos F, Hjorth MF, Astrup A. Diet and exercise in the prevention and treatment of type 2 diabetes mellitus. Nat Rev Endocrinol. 2020;16(10):545–55.

Article  PubMed  Google Scholar 

Barrett E, Eggleston E, Inyard A, Wang H, Li G, Chai W, et al. The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia. 2009;52(5):752–64.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li G, Barrett EJ, Wang H, Chai W, Liu Z. Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells. Endocrinology. 2005;146(11):4690–96.

Article  PubMed  CAS  Google Scholar 

Li G, Barrett EJ, Ko S-H, Cao W, Liu Z. Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells. Endocrinology. 2009;150(8):3475–82.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chisalita SI, Arnqvist HJ. Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells. Am J Physiol Endocrinol Metab. 2004;286(6):E896–901.

Article  PubMed  CAS  Google Scholar 

Dekker Nitert M, Chisalita SI, Olsson K, Bornfeldt KE, Arnqvist HJ. IGF-I/insulin hybrid receptors in human endothelial cells. Mol Cell Endocrinol. 2005;229(1–2):31–7.

Article  CAS  Google Scholar 

King GL, Johnson SM. Receptor-mediated transport of insulin across endothelial cells. Science. 1985;227(4694):1583–6.

Article  PubMed  CAS  Google Scholar 

Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest. 1996;98(4):894–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zeng G, Nystrom FH, Ravichandran LV, Cong L-N, Kirby M, Mostowski H, et al. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101(13):1539–45.

Article  PubMed  CAS  Google Scholar 

Oliver FJ, de la Rubia G, Feener EP, Lee ME, Loeken MR, Shiba T, et al. Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J Biol Chem. 1991;266(34):23251–6.

Article  PubMed  CAS  Google Scholar 

Eringa EC, Stehouwer CDA, Merlijn T, Westerhof N, Sipkema P. Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles. Cardiovascular Res. 2002;56(3):464–71.

Article  CAS  Google Scholar 

Eringa EC, Stehouwer CDA, van Nieuw Amerongen GP, Ouwehand L, Westerhof N, Sipkema P. Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium. Am J Physiol Heart Circ Physiol. 2004;287(5):H2043–8.

Article  PubMed  CAS  Google Scholar 

Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev. 2007;28(5):463–91.

Article  PubMed  CAS  Google Scholar 

Kim J-a, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113(15):1888–904.

Article  PubMed  Google Scholar 

Tamminen M, Westerbacka J, Vehkavaara S, Yki-Järvinen H. Insulin-induced decreases in aortic wave reflection and central systolic pressure are impaired in type 2 diabetes. Diabetes Care. 2002;25(12):2314–9.

Article  PubMed  CAS  Google Scholar 

Jahn LA, Hartline L, Rao N, Logan B, Kim JJ, Aylor K, et al. Insulin enhances endothelial function throughout the arterial tree in healthy but not metabolic syndrome subjects. J Clin Endocrinol Metab. 2016;101(3):1198–206.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tan AWK, Subaran SC, Sauder MA, Chai W, Jahn LA, Fowler DE, et al. GLP-1 and insulin recruit muscle microvasculature and dilate conduit artery individually but not additively in healthy humans. J Endocr Soc. 2018;2(2):190–206.