Rinella ME, Lazarus JV, Ratziu V, Ratziu V, Francque SM, Sanyal AJ, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023;79:1542–56.

Article  CAS  PubMed  Google Scholar 

Eslam M, Newsome PN, Sarin SK, Anstee QM, Targher G, Romero-Gomez M, et al. A new definition for metabolic associated fatty liver disease: an international expert consensus statement. J Hepatol. 2020;73:202–9.

Article  PubMed  Google Scholar 

Miao L, Targher G, Byrne CD, Cao YY, Zheng MH. Current status and future trends of the global burden of MASLD. Trends Endocrinol Metab. 2024;29:S1043. -2760(24)00036 – 5.

Google Scholar 

Calzadilla BL, Adams LA. The natural course of non-alcoholic fatty liver disease. Int J Mol Sci. 2016;17:774.

Article  Google Scholar 

Badmus OO, Hillhouse SA, Anderson CD, Hinds TD, Stec DE. Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways. Clin Sci (Lond). 2022;136:1347–66.

Article  CAS  PubMed  Google Scholar 

Powell EE, Wong VW-S, Rinella M. Non-alcoholic fatty liver disease. Lancet. 2021;397:2212–24.

Article  CAS  PubMed  Google Scholar 

Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726–35.

Article  CAS  PubMed  Google Scholar 

ter Horst KW, Serlie MJ. Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease. Nutrients. 2017;9:981.

Article  PubMed  PubMed Central  Google Scholar 

Softic S, Cohen DE, Kahn CR. Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig Dis Sci. 2016;61:1282–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, et al. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem. 1999;274:35832–39.

Article  CAS  PubMed  Google Scholar 

Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology-divergent pathophysiology. Nat Rev Endocrinol. 2017;13:710–30.

Article  CAS  PubMed  Google Scholar 

Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, et al. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. Science. 2022;376:eabf8271.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kemppainen RJ, Behrend EN. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem. 1998;273:3129–31.

Article  CAS  PubMed  Google Scholar 

Tu Y, Wu C. Cloning, expression and characterization of a novel human ras-related protein that is regulated by glucocorticoid hormone. Biochim Biophys Acta. 1999;1489:452–6.

Article  CAS  PubMed  Google Scholar 

Cheng HY, Obrietan K. Dexras1: shaping the responsiveness of the circadian clock. Semin Cell Dev Biol. 2006;17:345–51.

Article  CAS  PubMed  Google Scholar 

Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010;330:1349–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karatsoreos IN, Bhagat S, Bloss EB, Morrison JH, McEwen BS. Disruption of circadian clocks has ramifications for metabolism, brain, and behavior. Proc Natl Acad Sci U S A. 2011;108:1657–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eckel-Mahan KL, Patel VR, Mohney RP, Vignola KS, Baldi P, Sassone-Corsi P. Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A. 2012;109:5541–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lellis-Santos C, Sakamoto LH, Bromati CR, Nogueira TC, Leite AR, Yamanaka TS, et al. The regulation of Rasd1 expression by glucocorticoids and Prolactin Controls Peripartum maternal insulin secretion. Endocrinology. 2012;153:3668–78.

Article  CAS  PubMed  Google Scholar 

Jiang B, Lv Q, Wan W, Le L, Xu L, Hu K, et al. Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance. Food Funct. 2018;9:5607–20.

Article  CAS  PubMed  Google Scholar 

Høyer KL, Høgild ML, List EO, Lee KV, Kissinger E, Sharma R, et al. The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals. Physiol Rep. 2020;8:e14373.

Article  PubMed  PubMed Central  Google Scholar 

Smith GI, Shankaran M, Yoshino M, Schweitzer GG, Chondronikola M, Beals JW, et al. Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. J Clin Invest. 2020;130:1453–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lomonaco R, Ortiz-Lopez C, Orsak B, Hardies J, Darland C, Finch J, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histologyin obese patients with nonalcoholic fatty liver disease. Hepatology. 2012;55:1389–97.

Article  CAS  PubMed  Google Scholar 

Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 2007;87:507–20.

Article  CAS  PubMed  Google Scholar 

Cha JY, Kim HJ, Yu JH, Xu J, Kim D, Paul BD, et al. Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110:20575–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song QQ, Rao Y, Tang GH, Sun ZH, Zhang JH, Huang ZS, et al. Tigliane Diterpenoids as a New type of Antiadipogenic agents Inhibit GRα-Dexras1 Axis in Adipocytes. J Med Chem. 2019;62:2060–75.

Article  CAS  PubMed  Google Scholar 

Seok JW, Kim D, Yoon BK, Lee Y, Kim HJ, Kim HJ, et al. Dexras1 plays a pivotal role in maintaining the equilibrium between adipogenesis and osteogenesis. Metabolism. 2020;108:154250.

Article  CAS  PubMed  Google Scholar 

Tong J, Cong L, Jia Y, He BL, Guo Y, He J, et al. Follistatin Alleviates Hepatic Steatosis in NAFLD via the mTOR dependent pathway. Diabetes Metab Syndr Obes. 2022;15:3285–301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Chen J, Huang J, Li Z, Gong Y, Zou B, et al. HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway. Aging. 2019;11:10839–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Zhang X, Jia B, Cao Y, Yan K, Li JY, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway. J Pharmacol Sci. 2021;147:143–55.

Article  CAS  PubMed  Google Scholar 

Dou C, Sun L, Wang L, Cheng J, Wu W, Zhang C, et al. Bromodomain-containing protein 9 promotes the growth and metastasis of human hepatocellular carcinoma by activating the TUFT1/AKT pathway. Cell Death Dis. 2020;11:730.