van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.

Article  PubMed  Google Scholar 

Huang J, Wang X, Wang Z, Deng L, Wang Y, Tang Y, Luo L, Leung EL. Extracellular vesicles as a novel mediator of interkingdom communication. Cytokine Growth Factor Rev. 2023;73:173.

Article  CAS  PubMed  Google Scholar 

Cheng L, Hill AF. Therapeutically harnessing extracellular vesicles. Nat Rev Drug Discov. 2022;21(5):379–99.

Article  CAS  PubMed  Google Scholar 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–9.

Article  CAS  PubMed  Google Scholar 

Bjørge IM, Kim SY, Mano JF, Kalionis B, Chrzanowski W. Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine—a new paradigm for tissue repair. Biomater Sci. 2017;6(1):60–78.

Article  PubMed  Google Scholar 

Herrmann IK, Wood MJA, Fuhrmann G. Extracellular vesicles as a next-generation drug delivery platform. Nat Nanotechnol. 2021;16(7):748–59.

Article  CAS  PubMed  Google Scholar 

Hu Y, Li X, Zhang Q, Gu Z, Luo Y, Guo J, Wang X, Jing Y, Chen X, Su J. Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss. Bioact Mater. 2021;6(9):2905–13.

CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Zhang Q, Wang S, Weng W, Jing Y, Su J. Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: advances and perspectives. Bioact Mater. 2022;14:169–81.

CAS  PubMed  Google Scholar 

Lu H, Niu L, Yu L, Jin K, Zhang J, Liu J, Zhu X, Wu Y, Zhang Y. Cancer phototherapy with nano-bacteria biohybrids. J Control Release. 2023;360:133–48.

Article  CAS  PubMed  Google Scholar 

Hosseinidoust Z, Mostaghaci B, Yasa O, Park B-W, Singh AV, Sitti M. Bioengineered and biohybrid bacteria-based systems for drug delivery. Adv Drug Deliv Rev. 2016;106:27–44.

Article  CAS  PubMed  Google Scholar 

Liu H, Geng Z, Su J. Engineered mammalian and bacterial extracellular vesicles as promising nanocarriers for targeted therapy. Extracell Vesicles Circ Nucleic Acids. 2022;3(2):63–86.

Article  CAS  Google Scholar 

Li S, Jiang W, Zheng C, Shao D, Liu Y, Huang S, Han J, Ding J, Tao Y, Li M. Oral delivery of bacteria: basic principles and biomedical applications. J Control Release. 2020;327:801–33.

Article  CAS  PubMed  Google Scholar 

Chen Q, Rozovsky S, Chen W. Engineering multi-functional bacterial outer membrane vesicles as modular nanodevices for biosensing and bioimaging. Chem Commun (Camb). 2017;53(54):7569–72.

Article  CAS  PubMed  Google Scholar 

Stejskal L, Thistlethwaite A, Ramirez-Bencomo F, Rashmi S, Harrison O, Feavers IM, Maiden MCJ, Jerse A, Barnes G, Chirro O, Chemweno J, Nduati E, Cehovin A, Tang C, Sanders EJ, Derrick JP. Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population. Nat Commun. 2024;15(1):6712.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosseini-Giv N, Basas A, Hicks C, El-Omar E, El-Assaad F, Hosseini-Beheshti E. Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer. Front Cell Infect Microbiol. 2022;12: 962216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turnbull L, Toyofuku M, Hynen AL, Kurosawa M, Pessi G, Petty NK, Osvath SR, Cárcamo-Oyarce G, Gloag ES, Shimoni R, Omasits U, Ito S, Yap X, Monahan LG, Cavaliere R, Ahrens CH, Charles IG, Nomura N, Eberl L, Whitchurch CB. Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms. Nat Commun. 2016;7:11220.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shockman GD, Barren JF. Structure, function, and assembly of cell walls of gram-positive bacteria. Annu Rev Microbiol. 1983;37(1):501–27.

Article  CAS  PubMed  Google Scholar 

Raetz CR, Whitfield C. Lipopolysaccharide endotoxins. Annu Rev Biochem. 2002;71:635–700.

Article  CAS  PubMed  Google Scholar 

Toyofuku M, Nomura N, Eberl L. Types and origins of bacterial membrane vesicles. Nat Rev Microbiol. 2019;17(1):13–24.

Article  CAS  PubMed  Google Scholar 

Kulp A, Kuehn MJ. Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol. 2010;64:163–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schertzer JW, Whiteley M. A bilayer-couple model of bacterial outer membrane vesicle biogenesis. MBio. 2012;3(2): e00297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deatherage BL, Lara JC, Bergsbaken T, Rassoulian Barrett SL, Lara S, Cookson BT. Biogenesis of bacterial membrane vesicles. Mol Microbiol. 2009;72(6):1395–407.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toyofuku M, Cárcamo-Oyarce G, Yamamoto T, Eisenstein F, Hsiao CC, Kurosawa M, Gademann K, Pilhofer M, Nomura N, Eberl L. Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis. Nat Commun. 2017;8(1):481.

Article  PubMed  PubMed Central  Google Scholar 

Brown L, Wolf JM, Prados-Rosales R, Casadevall A. Through the wall: extracellular vesicles in gram-positive bacteria, mycobacteria and fungi. Nat Rev Microbiol. 2015;13(10):620–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Thompson CD, Weidenmaier C, Lee JC. Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform. Nat Commun. 2018;9(1):1379.

Article  PubMed  PubMed Central  Google Scholar 

Brennan CA, Hunt JR, Kremer N, Krasity BC, Apicella MA, McFall-Ngai MJ, Ruby EG. A model symbiosis reveals a role for sheathed-flagellum rotation in the release of immunogenic lipopolysaccharide. Elife. 2014;3: e01579.

Article  PubMed  PubMed Central  Google Scholar 

Devos S, Van Putte W, Vitse J, Van Driessche G, Stremersch S, Van Den Broek W, Raemdonck K, Braeckmans K, Stahlberg H, Kudryashev M, Savvides SN, Devreese B. Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress. Environ Microbiol. 2017;19(10):3930–7.

Article  CAS  PubMed  Google Scholar 

Zheng K, Feng Y, Li L, Kong F, Gao J, Kong X. Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors. Theranostics. 2024;14(2):761–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kroniger T, Otto A, Becher D. Proteomic analysis of bacterial (outer) membrane vesicles: progress and clinical potential. Expert Rev Proteomics. 2018;15(8):623–6.

Article  CAS  PubMed  Google Scholar 

Dutta S, Iida K, Takade A, Meno Y, Nair GB, Yoshida S. Release of Shiga toxin by membrane vesicles in Shigella dysenteriae serotype 1 strains and in vitro effects of antimicrobials on toxin production and release. Microbiol Immunol. 2004;48(12):965–9.