Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil

Adams SS, McCullough KF, Nicholson JS (1975) Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. Arzneimittelforschung 25:1786–1791

CAS  PubMed  Google Scholar 

Agrawal R, Lee CS, Gonzalez-Lopez JJ, Khan S, Rodrigues V, Pavesio C (2016) Flurbiprofen: a nonselective cyclooxygenase (COX) inhibitor for treatment of noninfectious, non-necrotizing anterior scleritis. Ocul Immunol Inflamm 24:35–42

Article  CAS  PubMed  Google Scholar 

Ahmad R, Ibrahim O (2024) Anti-inflammatory activity of clove (Syzygium aromaticum) oil extract against chronic inflammation in rat. Adv Anim Vet Sci 12:77–84

Google Scholar 

Andleeb, F., Asif, M. & Yaseen, H. S. 2022. Exploration of molecular mechanisms responsible for anti-inflammatory and anti-angiogenic attributes of methanolic extract of Viola betonicifolia. Inflammopharmacology. pp. 1–16.

Arooj B, Asghar S, Saleem M, Khalid SH, Asif M, Chohan T, Khan IU, Zubair HM, Yaseen HS (2023) Anti-inflammatory mechanisms of eucalyptol rich Eucalyptus globulus essential oil alone and in combination with flurbiprofen. Inflammopharmacology 31:1849–1862

Article  CAS  PubMed  Google Scholar 

Ashraf Z, Alamgeer MK, Hassan M, Abdullah S, Waheed M, Ahsan H, Kim SJ (2016) Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling. Drug Design, Dev Ther 10:2401

Article  CAS  Google Scholar 

Asif M, Yehya AH, Al-Mansoub MA, Revadigar V, Ezzat MO, Ahamed MB, Oon CE, Murugaiyah V, Majid AS, Majid AM (2016) Anticancer attributes of Illicium verum essential oils against colon cancer. South Afr J Bot. 103:156–61

Article  CAS  Google Scholar 

Bachiega TF, de Sousa JP, Bastos JK, Sforcin JM (2012) Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages. J Pharm Pharmacol 64:610–616

Article  CAS  PubMed  Google Scholar 

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9:7204

Article  PubMed  Google Scholar 

De Almeida Barros TA, De Freitas LA, Filho JM, Nunes XP, Giulietti AM, De Souza GE, Dos Santos RR, Soares MB, Villarreal C (2010) Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain. J Pharm Pharmacol 62:205–213

Article  Google Scholar 

Dhanda S, Evans A, Roy D, Osborne V, Townsley A, Coutinho G, Kulasekaran A, Shakir S (2021) A systematic review of flurbiprofen 875 mg dose and risk of haemorrhagic events. Front Pharmacol. 12:726141

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dzoyem J, Mcgaw L, Kuete V, Bakowsky U (2017) Anti-inflammatory and anti-nociceptive activities of African medicinal spices and vegetables Medicinal spices and vegetables from Africa. Elsevier, New York

Google Scholar 

Ekor M (2014) The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 4:177

Article  PubMed  PubMed Central  Google Scholar 

Fiaz M, Asif M, Khan KUR (2024) Launaea fragilis extract attenuated arthritis in rats through modulation of IL-1β, TNF-α, IL-6, NF-κB, COX-2, IL-4, and IL-10. Inflammopharmacology 32:2427–2443

Article  CAS  PubMed  Google Scholar 

Hobani YH, Mohan S, Shaheen E, Abdelhaleem A, Faruque Ahmad M, Bhatia S, Abou-Elhamd AS (2022) Gastroprotective effect of low dose Eugenol in experimental rats against ethanol induced toxicity: involvement of antiinflammatory and antioxidant mechanism. J Ethnopharmacol 289:115055

Article  CAS  PubMed  Google Scholar 

Huang G-J, Huang S-S, Lin S-S, Shao Y-Y, Chen C-C, Hou W-C, Kuo Y-H (2010) Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3β-ol from Antrodia camphorata submerged whole broth in mice. J Agric Food Chem 58:7445–7452

Article  CAS  PubMed  Google Scholar 

Kaur G, Sultana S (2012) Evaluation of antiarthritic activity of isoeugenol in adjuvant induced arthritis in murine model. Food Chem Toxicol 50:2689–2695

Article  CAS  PubMed  Google Scholar 

Khan H, Khan MA, Khan A, Tariq SA, Pervez S (2014) Antipyretic activity of decoction of Joshanda and its saponin and sterol contents: validation in an animal-based model. J Evid Based Complementary Altern Med 19:99–103

Article  CAS  PubMed  Google Scholar 

Laurindo LF, De Carvalho GM, De Oliveira Zanuso B, Figueira ME, Direito R, De Alvares Goulart R, Buglio DS, Barbalho SM (2023) Curcumin-based nanomedicines in the treatment of inflammatory and immunomodulated diseases: an evidence-based comprehensive review. Pharmaceutics 15:229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noh ASM, Chuan TD, Khir NAM, Zin AAM, Ghazali AK, Long I, Ab Aziz CB, Ismail CAN (2021) Effects of different doses of complete Freund’s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis. Plos one. 16:e0260423

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paliwal S, Tilak A, Sharma J, Dave V, Sharma S, Yadav R, Patel S, Verma K, Tak K (2019) Flurbiprofen loaded ethosomes-transdermal delivery of anti-inflammatory effect in rat model. Lipids in Health Disease 18:1–15

Article  CAS  Google Scholar 

Panahzadeh F, Mirnasuri R, Rahmati M (2022) Exercise and Syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in Alzheimer’s disease. J Ethnopharmacol 286:114871

Article  CAS  PubMed  Google Scholar 

Poudel, P., Goyal, A. & Lappin, S. L. 2024. Inflammatory Arthritis. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Amandeep Goyal declares no relevant financial relationships with ineligible companies Disclosure: Sarah Lappin declares no relevant financial relationships with ineligible companies. StatPearls Publishing. Copyright © 2024, StatPearls Publishing LLC

Raeisi E, Aazami MH, Aghamiri SMR, Satari A, Hosseinzadeh S, Lemoigne Y, Heidarian E (2020) Bromelain-based chemo-herbal combination effect on human cancer cells: in-vitro study on AGS and MCF7 proliferation and apoptosis. Pharm Med Sci 33:155–161

CAS  Google Scholar 

Saleem M, Asif M, Parveen A, Yaseen HS, Saadullah M, Bashir A, Asif J, Arif M, Khan IU, Khan RU (2021) Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus. Inflammopharmacology. 29:281–93

Article  CAS  PubMed  Google Scholar 

Saleem M, Iftikhar A, Asif M, Hussain K, Shah PA, Saleem A, Akhtar MF, Tanzeem M, Yaseen HS (2021b) Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-α, NF-κB, ILs, and COX-2 activities in in vivo models. Inflammopharmacology 29:483–497

Article  CAS  PubMed  Google Scholar 

Santin JR, Lemos M, Klein-Júnior LC, Machado ID, Costa P, de Oliveira AP, Tilia C, de Souza JP, de Sousa JP, Bastos JK, de Andrade SF (2011) Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch Pharmacol 383:149–158

Article  CAS  PubMed  Google Scholar 

Copyright © 2024, StatPearls Publishing LLC.

Sun W, Sanderson PE, Zheng W (2016) Drug combination therapy increases successful drug repositioning. Drug Discov Today 21:1189–1195

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taher, Y. A., Samud, A. M., El-Taher, F. E., Ben-Hussin, G., Elmezogi, J. S., Al-Mehdawi, B. F. & Salem, H. A.: Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil inmice. Libyan Journal of Medicine, 10. 2015

Tanzeem MU, Asghar S, Khalid SH, Asif M, Ullah MS, Khan IU, Khalid I, Faran SA, Rehman A, Gohar UF, Hussain T (2019) Clove oil based co-surfactant free microemulsion of flurbiprofen: Improved solubility with ameliorated drug-induced gastritis. Pak J Pharm Sci 32:2787–2793

CAS  PubMed  Google Scholar 

Triastuti A, Pradana DA, Saputra DE, Lianika N, Wicaksono HR, Anisari TD, Widyarini S (2022) Anti-rheumatoid activity of a hexane-insoluble fraction from Plantago major in female Wistar rats induced by Complete Freund’s Adjuvant. J Tradit Complement Med 12:219–224

Article  CAS  PubMed  Google Scholar 

Tsai T-H, Huang W-C, Lien T-J, Huang Y-H, Chang H, Yu C-H, Tsai P-J (2017) Clove extract and eugenol suppress inflammatory responses elicited by Propionibacterium acnes in vitro and in vivo. Food Hydrocolloids 28:916–931

CAS  Google Scholar 

Vora LK, Gholap AD, Hatvate NT, Naren P, Khan S, Chavda VP, Balar PC, Gandhi J, Khatri DK (2024) Essential oils for clinical aromatherapy: A comprehensive review. J Ethnopharmacol 330:118180

Article  CAS  PubMed  Google Scholar 

Weiss G, Bogdan C, Hentze MW (1997) Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. J Immunol 158:420–425

Article  CAS  PubMed 

留言 (0)

沒有登入
gif