Gustavsson A, Norton N, Fast T, Frölich L, Georges J, Holzapfel D, et al. Global estimates on the number of persons across the Alzheimer’s disease continuum. Alzheimers Dement. 2023;19(2):658–70.
Duyckaerts C, Delatour B, Potier MC. Classification and basic pathology of Alzheimer disease. Acta Neuropathol. 2009;118(1):5–36.
Article CAS PubMed Google Scholar
Carrette O, Demalte I, Scherl A, Yalkinoglu O, Corthals G, Burkhard P, et al. A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer’s disease. Proteomics. 2003;3(8):1486–94.
Article CAS PubMed Google Scholar
Huang YM, Ma YH, Gao PY, Wang ZB, Huang LY, Hou JH, et al. Plasma β(2)-microglobulin and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study. Alzheimer's Res Ther. 2023;15(1):69.
Boulanger LM, Shatz CJ. Immune signalling in neural development, synaptic plasticity and disease. Nat Rev Neurosci. 2004;5(7):521–31.
Article CAS PubMed Google Scholar
Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ. Functional requirement for class I MHC in CNS development and plasticity. Science (New York, NY). 2000;290(5499):2155–9.
Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, et al. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med. 2015;21(8):932–7.
Article CAS PubMed PubMed Central Google Scholar
Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, et al. β(2)-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice. Nat Neurosci. 2023;26(7):1170–84.
Article CAS PubMed Google Scholar
van Westrhenen A, Smidt LC, Seute T, Nierkens S, Stork AC, Minnema MC, et al. Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review. Br J Haematol . 2018;182(3):384–403.
Article PubMed PubMed Central Google Scholar
Padovani A, Canale A, Schiavon L, Masciocchi S, Imarisio A, Risi B, et al. Is amyloid involved in acute neuroinflammation? A CSF analysis in encephalitis. Alzheimers Dement . 2022;18(11):2167–75.
Article CAS PubMed Google Scholar
Patani R, Hardingham GE, Liddelow SA. Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration. Nat Rev Neurol. 2023;19(7):395–409.
Article CAS PubMed Google Scholar
Zhang PF, Hu H, Tan L, Yu JT. Microglia Biomarkers in Alzheimer’s Disease. Mol Neurobiol. 2021;58(7):3388–404.
Article CAS PubMed Google Scholar
Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014;6(243):243ra86.
Colonna M, Wang Y. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nat Rev Neurosci. 2016;17(4):201–7.
Article CAS PubMed Google Scholar
Suárez-Calvet M, Kleinberger G, Araque Caballero M, Brendel M, Rominger A, Alcolea D, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers. EMBO Mol Med. 2016;8(5):466–76.
Article PubMed PubMed Central Google Scholar
Uddin MS, Lim LW. Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications. Ageing Res Rev. 2022;78:101622.
Article CAS PubMed Google Scholar
Bombeiro AL, Hell RC, Simões GF, Castro MV, Oliveira AL. Importance of major histocompatibility complex of class I (MHC-I) expression for astroglial reactivity and stability of neural circuits in vitro. Neurosci Lett. 2017;647:97–103.
Article CAS PubMed Google Scholar
Ignarro RS, Bombeiro AL, Chiarotto GB, Cartarozzi LP, Coser LO, Ghizoni E, et al. Interferon-beta induces major histocompatibility complex of class I (MHC-I) expression and a proinflammatory phenotype in cultivated human astrocytes. Differentiation. 2022;128:43–56.
Article CAS PubMed Google Scholar
Carter SF, Herholz K, Rosa-Neto P, Pellerin L, Nordberg A, Zimmer ER. Astrocyte Biomarkers in Alzheimer’s Disease. Trends Mol Med. 2019;25(2):77–95.
Article CAS PubMed Google Scholar
Olsen M, Aguilar X, Sehlin D, Fang XT, Antoni G, Erlandsson A, et al. Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer’s Disease. Mol Imag Biol. 2018;20(4):605–14.
Carrillo MC, Masliah E, editors. NIA-AA Revised Clinical Criteria for Alzheimer's Disease. Alzheimer's Association International Conference: ALZ; 2023.
Guo Y, You J, Zhang Y, Liu WS, Huang YY, Zhang YR, et al. Plasma proteomic profiles predict future dementia in healthy adults. Nature Aging. 2024;4(2):247–60.
Article CAS PubMed Google Scholar
Wu C, Liu TC, Duan R, Yang L. β2‐microglobulin: An essential coaggregation factor with β‐amyloid in amyloid pathology. Brain-X. 2023;1(4):49.
Aisen PS, Petersen RC, Donohue M, Weiner MW. Alzheimer’s Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans. Alzheimers Dement. 2015;11(7):734–9.
Spellman DS, Wildsmith KR, Honigberg LA, Tuefferd M, Baker D, Raghavan N, et al. Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer’s Disease Neuroimaging Initiative (ADNI) CSF. Proteomics Clin Appl. 2015;9(7–8):715–31.
Article CAS PubMed PubMed Central Google Scholar
Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, et al. CSF progranulin increases in the course of Alzheimer’s disease and is associated with sTREM 2, neurodegeneration and cognitive decline. EMBO Mol Med. 2018;10(12):e9712.
Article PubMed PubMed Central Google Scholar
Bittner T, Zetterberg H, Teunissen CE, Ostlund RE Jr, Militello M, Andreasson U, et al. Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid. Alzheimers Dement. 2016;12(5):517–26.
Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Araque Caballero M, Franzmeier N, et al. Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Mol Neurodegener. 2019;14(1):1.
Article PubMed PubMed Central Google Scholar
Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, et al. Blood-based protein biomarkers for diagnosis of Alzheimer disease. Arch Neurol. 2012;69(10):1318–25.
Article PubMed PubMed Central Google Scholar
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535–62.
Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.
Article CAS PubMed Google Scholar
Ayton S, Wang Y, Diouf I, Schneider JA, Brockman J, Morris MC, et al. Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology. Mol Psychiatry. 2020;25(11):2932–41.
Article CAS PubMed Google Scholar
Yoo C, Yoon DH, Kim S, Huh J, Park CS, Park CJ, et al. Serum beta-2 microglobulin as a prognostic biomarker in patients with mantle cell lymphoma. Hematol Oncol. 2016;34(1):22–7.
留言 (0)