Carling T, Udelsman R. Thyroid Cancer. 2014;65:125–37. https://doi.org/101146/annurev-med-061512-105739. Available from: https://www.annualreviews.org/doi/abs/10.1146/annurev-med-061512-105739. [cited 2023 Sep 18].

Stamatakos M, Paraskeva P, Stefanaki C, Katsaronis P, Lazaris A, Safioleas K, et al. Medullary thyroid carcinoma: The third most common thyroid cancer reviewed. Oncol Lett. 2011;2(1):49. Available from: https://www.spandidos-publications.com/10.3892/ol.2010.223.

Article  PubMed  Google Scholar 

Jannin A, Escande A, Al Ghuzlan A, et al. Anaplastic Thyroid Carcinoma: An Update. Cancers (Basel). 2022;14(4). Available from: https://www.mdpi.com/2072-6694/14/4/1061.

Schlumberger M, Leboulleux S. Current practice in patients with differentiated thyroid cancer. Nat Rev Endocrinol. 2020;17(3):176–88. Available from: https://www.nature.com/articles/s41574-020-00448-z. [cited 2023 Sep 18].

Article  PubMed  Google Scholar 

Schmid KW. Histopathology of C Cells and Medullary Thyroid Carcinoma. Recent Results Cancer Res. 2015;204:41–60. Available from: https://pubmed.ncbi.nlm.nih.gov/26494383/. [cited 2023 Sep 18].

Article  PubMed  Google Scholar 

Roy M, Chen H, Sippel RS. Current understanding and management of medullary thyroid cancer. Oncologist. 2013;18(10):1093–100. Available from: https://pubmed.ncbi.nlm.nih.gov/24037980/. [cited 2023 Sep 18].

Article  PubMed  PubMed Central  Google Scholar 

Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Hoff AO, et al. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid. 2005;15(6):531–44. Available from: https://pubmed.ncbi.nlm.nih.gov/16029119/. [cited 2023 Oct 6].

Article  CAS  PubMed  Google Scholar 

Arighi E, Borrello MG, Sariola H. RET tyrosine kinase signaling in development and cancer. Cytokine Growth Factor Rev. 2005;16(4–5):441–67. Available from: https://pubmed.ncbi.nlm.nih.gov/15982921/. [cited 2023 Sep 18].

Article  CAS  PubMed  Google Scholar 

Anders J, Kjær S, Ibáñez CF. Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J Biol Chem. 2001;276(38):35808–17. Available from: https://pubmed.ncbi.nlm.nih.gov/11445581/. [cited 2023 Sep 18].

Article  CAS  PubMed  Google Scholar 

Grubbs EG, Ng PKS, Bui J, Busaidy NL, Chen K, Lee JE, et al. RET Fusion as a Novel Driver of Medullary Thyroid Carcinoma. J Clin Endocrinol Metab. 2015;100(3):788–93. https://doi.org/10.1210/jc.2014-4153. [cited 2023 Sep 22].

Article  CAS  PubMed  Google Scholar 

Okafor C, Hogan J, Raygada M, Thomas BJ, Akshintala S, Glod JW, et al. Update on Targeted Therapy in Medullary Thyroid Cancer. Front Endocrinol (Lausanne). 2021;12. Available from: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.708949/full.

Romei C, Ciampi R, Elisei R. A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma. Nat Rev Endocrinol. 2016;12(4):192–202.

Article  CAS  PubMed  Google Scholar 

Kodama Y, Asai N, Kawai K, Jijiwa M, Murakumo Y, Ichihara M, et al. The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Sci. 2005;96(3):143–8. Available from: https://pubmed.ncbi.nlm.nih.gov/15771616/. [cited 2023 Sep 20].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wirth LJ, Brose MS, Elisei R, Capdevila J, Hoff AO, Hu MI, et al. LIBRETTO-531: A phase III study of selpercatinib in multikinase inhibitor-naïve RET-mutant medullary thyroid cancer. Future Oncol. 2022;18(28):3143–50. Available from: https://www.futuremedicine.com/doi/10.2217/fon-2022-0657. [cited 2023 Sep 18].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elisei R, Schlumberger MJ, Müller SP, Schöffski P, Brose MS, Shah MH, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013;31(29):3639–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Højer Wang L, Wehland M, Wise PM, Infanger M, Grimm D, Kreissl MC. Cabozantinib, Vandetanib, Pralsetinib and Selpercatinib as Treatment for Progressed Medullary Thyroid Cancer with a Main Focus on Hypertension as Adverse Effect. Int J Mol Sci. 2023;24(3):2312.

Article  PubMed  PubMed Central  Google Scholar 

Solomon B, Rischin D. Progress in molecular targeted therapy for thyroid cancer: Vandetanib in medullary thyroid cancer. J Clin Oncol. 2012;30(2):119–21.

Article  CAS  PubMed  Google Scholar 

Wells SA, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial. J Clin Oncol. 2012;30(2):134–41.

Article  CAS  PubMed  Google Scholar 

Andrew SD, Delhanty PJD, Mulligan LM, Robinson BG. Sp1 and Sp3 transactivate the RET proto-oncogene promoter. Gene. 2000;256(1–2):283–91. Available from: https://pubmed.ncbi.nlm.nih.gov/11054558/. [cited 2023 Sep 22].

Article  CAS  PubMed  Google Scholar 

Andrew SD, Capes-Davis A, Delhanty PJD, Marsh DJ, Mulligan LM, Robinson BG. Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway. Gene. 2002;298(1):9–19. Available from: https://pubmed.ncbi.nlm.nih.gov/12406571/. [cited 2023 Sep 22].

Article  CAS  PubMed  Google Scholar 

Todd AK, Neidle S. The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res. 2008;36(8):2700–4. Available from: https://pubmed.ncbi.nlm.nih.gov/18353860/. [cited 2023 Sep 22].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mccarthy JG, Heywood SM. A long polypyrimidine/polypurine tract induces an altered DNA conformation on the 3’ coding region of the adjacent myosin heavy chain gene. Nucleic Acids Res. 1987;15(19):8069. Available from: https://academic.oup.com/nar/article/15/19/8069/1078606?login=false .

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun D, Guo K, Rusche JJ, Hurley LH. Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Res. 2005;33(18):6070–80. Available from: https://pubmed.ncbi.nlm.nih.gov/16239639/. [cited 2023 Sep 22].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parkinson GN, Lee MPH, Neidle S. Crystal structure of parallel quadruplexes from human telomeric DNA. Nature. 2002;6891:876–80. Available from: https://www.nature.com/articles/nature755. [cited 2023 Sep 22].

Article  Google Scholar 

Phan AT, Modi YS, Patel DJ. Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc. 2004;126(28):8710–6. Available from: https://pubs.acs.org/doi/abs/10.1021/ja048805k. [cited 2023 Sep 22].

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumarasamy VM, Shin YJ, White J, Sun D. Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine. BMC Cancer. 2015;15(1). Available from: https://pubmed.ncbi.nlm.nih.gov/26307103/. [cited 2023 Sep 19]

Spiegel J, Adhikari S, Balasubramanian S. The Structure and Function of DNA G-Quadruplexes. Trends Chem. 2020;2(2):123–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alqahtani T, Kumarasamy V, Alghamdi SS, Suliman RS, Bin Saleh K, Alrashed MA, et al. Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes. Cancers (Basel). 2023;15(7). Available from: https://pubmed.ncbi.nlm.nih.gov/37046823/. [cited 2023 Sep 18].

Shin YJ, Kumarasamy V, Camacho D, Sun D. Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells. Oncogene. 2015;34(10):1292–9. Available from: https://www.nature.com/articles/onc201465. 2014 Mar 24 [cited 2023 Sep 18].

Article  CAS  PubMed  Google Scholar 

Kaushik V, Yakisich JS, Kumar A, Azad N, Iyer AKV. Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers. Cancers (Basel). 2018;10(10). Available from: https://www.mdpi.com/2072-6694/10/10/360.

Martínez-Haya B, Avilés-Moreno JR, Hamad S, Elguero J. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017;19(2):1288–97. Available from: https://pubmed.ncbi.nlm.nih.gov/27966685/. [cited 2023 Sep 18].

Article  PubMed  Google Scholar 

Avilés-Moreno JR, Gámez F, Berden G, Oomens J, Martínez-Haya B. Isolated alkali cation complexes of the antibiotic ionophore nonactin: Correlation with crystalline structures. Phys Chem Chem Phys. 2017;19(23):14984–91.

Article