Hirota T, King BH. Autism spectrum disorder: a review. JAMA. 2023;329(2):157–68.

Article  CAS  PubMed  Google Scholar 

Li YA, Chen ZJ, Li XD, Gu MH, Xia N, Gong C, Zhou ZW, Yasin G, Xie HY, Wei XP, et al. Epidemiology of autism spectrum disorders: global burden of disease 2019 and bibliometric analysis of risk factors. Front Pediatr. 2022;10:972809.

Article  PubMed  PubMed Central  Google Scholar 

Megari K, Frantzezou CK, Polyzopoulou ZA, Tzouni SK. Neurocognitive features in childhood & adulthood in autism spectrum disorder: a neurodiversity approach. Int J Dev Neuroscience: Official J Int Soc Dev Neurosci 2024.

Littman ER, Gavin L, Broda A, Hodges AC, Spector L. Barriers to receiving applied behavior analysis services in children with autism spectrum disorder. Cureus. 2023;15(11):e48585.

PubMed  PubMed Central  Google Scholar 

Hodgson R, Biswas M, Palmer S, Marshall D, Rodgers M, Stewart L, Simmonds M, Rai D, Le Couteur A. Intensive behavioural interventions based on applied behaviour analysis (ABA) for young children with autism: a cost-effectiveness analysis. PLoS ONE. 2022;17(8):e0270833.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brondino N, Fusar-Poli L, Rocchetti M, Provenzani U, Barale F, Politi P. Complementary and alternative therapies for autism spectrum disorder. Evid Based Complement Alternat Med. 2015;2015:258589.

Article  PubMed  PubMed Central  Google Scholar 

Morton JT, Jin D-M, Mills RH, Shao Y, Rahman G, McDonald D, Zhu Q, Balaban M, Jiang Y, Cantrell K, et al. Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles. Nat Neurosci. 2023;26(7):1208–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Madra M, Ringel R, Margolis KG. Gastrointestinal issues and Autism Spectrum Disorder. Child Adolesc Psychiatr Clin N Am. 2020;29(3):501–13.

Article  PubMed  PubMed Central  Google Scholar 

Fattorusso A, Di Genova L, Dell’Isola GB, Mencaroni E, Esposito S. Autism Spectrum disorders and the gut microbiota. Nutrients 2019, 11(3).

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155(7):1451–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anton V, Emmanuel M. FRCP: Efficacy of vivomixx on behaviour and gut function in autism spectrum disorder (VIVO-ASD) (NCT03369431). In.; 2022-03–8.

Arnold LE, Luna RA, Williams K, Chan J, Parker RA, Wu Q, Hollway JA, Jeffs A, Lu F, Coury DL, et al. Probiotics for gastrointestinal symptoms and quality of life in Autism: a placebo-controlled pilot trial. J Child Adolesc Psychopharmacol. 2019;29(9):659–69.

Article  PubMed  PubMed Central  Google Scholar 

Billeci L, Callara AL, Guiducci L, Prosperi M, Morales MA, Calderoni S, Muratori F, Santocchi E. A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism. Autism. 2023;27(1):117–32.

Article  PubMed  Google Scholar 

Kong XJ, Liu J, Liu K, Koh M, Sherman H, Liu S, Tian R, Sukijthamapan P, Wang J, Fong M et al. Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: a randomized, double-Blinded, placebo-controlled pilot trial. Nutrients 2021, 13(5).

Liu Y-W, Wang J-E, Sun F-J, Huang Y-H, Chen H-J. Probiotic intervention in young children with autism spectrum disorder in Taiwan: a randomized, double-blinded, placebo-controlled trial. Res Autism Spectr Disorders. 2023;109:102256.

Article  Google Scholar 

Liu YW, Liong MT, Chung YE, Huang HY, Peng WS, Cheng YF, Lin YS, Wu YY, Tsai YC. Effects of Lactobacillus plantarum PS128 on children with Autism Spectrum Disorder in Taiwan: a Randomized, Double-Blind, placebo-controlled trial. Nutrients 2019, 11(4).

Santocchi E, Guiducci L, Prosperi M, Calderoni S, Gaggini M, Apicella F, Tancredi R, Billeci L, Mastromarino P, Grossi E, et al. Effects of Probiotic supplementation on gastrointestinal, sensory and core symptoms in Autism Spectrum disorders: a Randomized Controlled Trial. Front Psychiatry. 2020;11:550593.

Article  PubMed  PubMed Central  Google Scholar 

Schmitt LM, Smith EG, Pedapati EV, Horn PS, Will M, Lamy M, Barber L, Trebley J, Meyer K, Heiman M, et al. Results of a phase ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder. Sci Rep. 2023;13(1):5192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Li N, Yang JJ, Zhao DM, Chen B, Zhang GQ, Chen S, Cao RF, Yu H, Zhao CY, et al. Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacol Res. 2020;157:104784.

Article  CAS  PubMed  Google Scholar 

Picard C, Fioramonti J, Francois A, Robinson T, Neant F, Matuchansky C. Review article: bifidobacteria as probiotic agents -- physiological effects and clinical benefits. Aliment Pharmacol Ther. 2005;22(6):495–512.

Article  CAS  PubMed  Google Scholar 

He X, Liu W, Tang F, Chen X, Song G. Effects of Probiotics on Autism Spectrum disorder in children: a systematic review and Meta-analysis of clinical trials. Nutrients 2023, 15(6).

Collado MC, Meriluoto J, Salminen S. In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal mucus. Food Res Int. 2007;40(5):629–36.

Article  CAS  Google Scholar 

Pandolfi V, Magyar CI. Assessment of Co-occurring Emotional and Behavioral Disorders in Youth with ASD Using the Child Behavior Checklist 6–18. In: Comprehensive Guide to Autism. edn. Edited by Patel VB, Preedy VR, Martin CR. New York, NY: Springer New York; 2014: 2799–2812.

Chua SY, Abd Rahman FN, Ratnasingam S. Problem behaviours and caregiver burden among children with Autism Spectrum Disorder in Kuching, Sarawak. Front Psychiatry 2023, 14.

Sepehrmanesh Z, Shahzeidi A, Mansournia MA, Ghaderi A, Ahmadvand A. Clinical and metabolic reaction to Probiotic supplement in children suffering attention-deficit hyperactivity disorder: a Randomized, Double-Blind, placebo-controlled experiment. Int Archives Health Sci 2021, 8(2).

Ghanaatgar M, Taherzadeh S, Ariyanfar S, Razeghi Jahromi S, Martami F, Mahmoudi Gharaei J, Teimourpour A, Shahrivar Z. Probiotic supplement as an adjunctive therapy with Ritalin for treatment of attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled randomized clinical trial. Nutr Food Sci. 2023;53(1):19–34.

Article  Google Scholar 

Lau-Zhu A, Fritz A, McLoughlin G. Overlaps and distinctions between attention deficit/hyperactivity disorder and autism spectrum disorder in young adulthood: systematic review and guiding framework for EEG-imaging research. Neurosci Biobehav Rev. 2019;96:93–115.

Article  PubMed  PubMed Central  Google Scholar 

Pärtty A, Kalliomäki M, Wacklin P, Salminen S, Isolauri E. A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatr Res. 2015;77(6):823–8.

Article  PubMed  Google Scholar 

Brett BE, Doumbia HOY, Koko BK, Koffi FK, Assa SE, Zahé KYAS, Kort R, Sybesma W, Reid G, de Weerth C. Normative cognition and the effects of a probiotic food intervention in first grade children in Côte d’Ivoire. Sci Rep. 2022;12(1):19491.

Article  PubMed  PubMed Central  Google Scholar 

Wu CC, Wong LC, Hsu CJ, Yang CW, Tsai YC, Cheng FS, Hu HY, Lee WT. Randomized Controlled Trial of Probiotic PS128 in children with Tourette Syndrome. Nutrients 2021, 13(11).

Alipour B, Homayouni-Rad A, Vaghef-Mehrabany E, Sharif SK, Vaghef-Mehrabany L, Asghari-Jafarabadi M, Nakhjavani MR, Mohtadi-Nia J. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double-blind clinical trial. Int J Rheum Dis. 2014;17(5):519–27.

Article  CAS  PubMed  Google Scholar 

Kullisaar T, Songisepp E, Mikelsaar M, Zilmer K, Vihalemm T, Zilmer M. Antioxidative probiotic fermented goats’ milk decreases oxidative stress-mediated atherogenicity in human subjects. Br J Nutr. 2003;90(2):449–56.

Article  CAS  PubMed  Google Scholar 

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1.

Article  PubMed  PubMed Central  Google Scholar 

McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb). 2012;22(3):276–82.

Article  PubMed  Google Scholar 

Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA. Cochrane handbook for systematic reviews of interventions. Wiley; 2019.

Book  Google Scholar 

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924.

Article  PubMed  PubMed Central  Google Scholar 

Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR, Yang HT, Tancredi DA-O, German JB, Slupsky CM et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One 2019, 1(1932–6203 (Electronic)).

Li YQ, Sun YH, Liang Yp Fau - Zhou F, Zhou F, Yang J, Jin SL. Effect of probiotics combined with applied behavior analysis in the treatment of children with autism spectrum disorder: a prospective randomized controlled trial. Zhongguo Dang Dai Er Ke Za Zhi. 2021;11(Print):1008–8830.

Google Scholar 

Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang NM, Cowan M, Moonah SN, Petri WA Jr.