Nardozza LM, et al. Fetal growth restriction: current knowledge. Arch Gynecol Obstet. 2017;295(5):1061–77.

Article  PubMed  Google Scholar 

Tesfa D, et al. Intrauterine growth restriction and its associated factors in South Gondar zone hospitals, Northwest Ethiopia, 2019. Arch Public Health. 2020;78:89.

Article  PubMed  PubMed Central  Google Scholar 

Armengaud JB, et al. Intrauterine growth restriction: Clinical consequences on health and disease at adulthood. Reprod Toxicol. 2021;99:168–76.

Article  CAS  PubMed  Google Scholar 

Malhotra A, et al. Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact. Front Endocrinol. 2019;10:55.

Article  Google Scholar 

Wilson RL, et al. Nanoparticle mediated increased insulin-like growth factor 1 expression enhances human placenta syncytium function. Placenta. 2020;93:1–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abd Ellah N, et al. Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy. PLoS One. 2015;10(10):e0140879.

Article  PubMed  PubMed Central  Google Scholar 

Wilson RL, et al. Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner. J Dev Orig Health Dis. 2023;14(3):325–332

Davenport BN, Jones HN, Wilson RL. Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua. Front Physiol. 2023;13:1055234

Davenport BN, et al. Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model. Gene Ther. 2024.

Wardinger JE, Ambati S. Placental insufficiency. In: StatPearls. Treasure Island, FL; 2024.

Sferruzzi-Perri AN, Lopez-Tello J, Salazar-Petres E. Placental adaptations supporting fetal growth during normal and adverse gestational environments. Exp Physiol. 2022;

Gong S, et al. The RNA landscape of the human placenta in health and disease. Nat Commun. 2021;12(1):2639.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bamfo JE, Odibo AO. Diagnosis and management of fetal growth restriction. J Pregnancy. 2011;2011:640715.

Article  PubMed  PubMed Central  Google Scholar 

Morrison JL, et al. Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. J Physiol. 2018;596(23):5535–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Enders AC, Blankenship TN. Comparative placental structure. Adv Drug Deliv Rev. 1999;38(1):3–15.

Article  CAS  PubMed  Google Scholar 

Mess A. The Guinea pig placenta: model of placental growth dynamics. Placenta. 2007;28(8-9):812–5.

Article  CAS  PubMed  Google Scholar 

Elias AA, et al. Maternal nutrient restriction in guinea pigs as an animal model for inducing fetal growth restriction. Reprod Sci. 2016;23(2):219–27.

Article  CAS  PubMed  Google Scholar 

Ghaly A, et al. Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with increased brain apoptosis. Pediatr Res. 2019;85(1):105–12.

Article  CAS  PubMed  Google Scholar 

Sohlstrom A, et al. Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig. Am J Physiol. 1998;274(3):E410–6.

CAS  PubMed  Google Scholar 

Randhawa RS. The insulin-like growth factor system and fetal growth restrictionn. Pediatr Endocrinol Rev. 2008;6(2):235–40.

PubMed  Google Scholar 

Hiden U, et al. Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat. 2009;215(1):60–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koutsaki M, et al. Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction. Growth Horm IGF Res. 2011;21(1):31–6.

Article  CAS  PubMed  Google Scholar 

Wilson RL, et al. Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations. Mol Reprod Dev. 2022;89(11):540–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson RL, et al. Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy. Pediatr Res. 2021;89(7):1673–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson RL, et al. Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth. Am J Physiol Regul Integr Comp Physiol. 2021;320(5):R653–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elias AA, et al. Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia. Pediatr Res. 2017;82(1):141–7.

Article  CAS  PubMed  Google Scholar 

Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30(15):2114–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ewels P, et al. MultiQC: summarize analysis results for multiple tools and samples in a single report. Bioinformatics. 2016;32(19):3047–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobin A, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2012;29(1):15–21.

Article  PubMed  PubMed Central  Google Scholar 

Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 2011;12(1):323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, et al. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 2009;37(Web Server issue):W305–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, et al. Recent advances: molecular mechanism of RNA oxidation and its role in various diseases. Front Mol Biosci. 2020;7

Martins SG, et al. Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components. Front Genet. 2021;12

Su LJ, et al. Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev. 2019;2019:5080843.

Article  PubMed  PubMed Central  Google Scholar 

Flick K, Kaiser P. Protein degradation and the stress response. Semin Cell Dev Biol. 2012;23(5):515–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burton GJ, Jauniaux E. Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol. 2018;218(2):S745–61.

Article  CAS  PubMed  Google Scholar 

Xu Y-Y, et al. Hypoxic effects on the mitochondrial content and functions of the placenta in fetal growth restriction. Placenta. 2021;114:100–7.

Article  CAS  PubMed  Google Scholar 

Yoshida A, et al. Placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction. J Matern Fetal Neonatal Med. 2018;31(8):1051–7.