Image-Based Measures of Obesity are Associated with Alterations in Metabolic Pathways in Non-small Cell Lung Cancer

Cheryl D, Fryar MSPH, Margaret D, Carroll MSPH, and Joseph Afful MS. Prevalence of overweight, obesity, and severe obesity among adults aged 20 and over: United States, 1960–1962 Through 2017–2018. NCHS Health E-Stats2020.

Cancer Intelligence Team CRU. When could overweight and obesity overtake smoking as the biggest cause of cancer in the UK? (2018).

Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52.

Article  PubMed  Google Scholar 

Leung CC, Lam TH, Yew WW, Chan WM, Law WS, Tam CM. Lower lung cancer mortality in obesity. Int J Epidemiol. 2011;40(1):174–82.

Article  PubMed  Google Scholar 

Hainer V, Aldhoon-Hainerová I. Obesity paradox does exist. Diabetes Care. 2013;36:S276-281.

Article  PubMed  PubMed Central  Google Scholar 

Gruberg L, Weissman NJ, Waksman R, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox?. J Am Coll Cardiol. 2002;39(4):578–84.

Article  PubMed  Google Scholar 

Carnethon MR, Rasmussen-Torvik LJ, Palaniappan L. The obesity paradox in diabetes. Curr Cardiol Rep. 2014;16(2):446.

Article  PubMed  Google Scholar 

Ichihara E, Harada D, Inoue K, et al. The impact of body mass index on the efficacy of anti-PD-1/PD-L1 antibodies in patients with non-small cell lung cancer. Lung Cancer. 2020;139:140–5.

Article  PubMed  Google Scholar 

Antonopoulos AS, Oikonomou EK, Antoniades C, Tousoulis D. From the BMI paradox to the obesity paradox: the obesity–mortality association in coronary heart disease. Obesity Rev. 2016;17(10):989–1000.

Article  CAS  Google Scholar 

Zhang X, Liu Y, Shao H, Zheng X. Obesity paradox in lung cancer prognosis: evolving biological insights and clinical implications. J Thorac Oncol. 2017;12(10):1478–88.

Article  PubMed  Google Scholar 

Hidayat K, Du X, Chen G, Shi M, Shi B. Abdominal obesity and lung cancer risk: systematic review and meta-analysis of prospective studies. Nutrients. 2016;8(12):810.

Article  PubMed  PubMed Central  Google Scholar 

Irlbeck T, Massaro JM, Bamberg F, O’Donnell CJ, Hoffmann U, Fox CS. Association between single-slice measurements of visceral and abdominal subcutaneous adipose tissue with volumetric measurements: the Framingham heart study. Int J Obes. 2010;34(4):781–7.

Article  CAS  Google Scholar 

Barbi J, Patnaik SK, Pabla S, et al. Visceral obesity promotes lung cancer progression-toward resolution of the obesity paradox in lung cancer. J Thorac Oncol. 2021;16(8):1333–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosario SR, Dong B, Zhang Y, et al. Metabolic dysregulation explains the diverse impacts of obesity in males and females with gastrointestinal cancers. Int J Mol Sci. 2023;24(13):10847.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosario SR, Long MD, Affronti HC, Rowsam AM, Eng KH, Smiraglia DJ. Pan-cancer analysis of transcriptional metabolic dysregulation using the cancer genome atlas. Nat Commun. 2018;9(1):5330.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petrelli F, Cortellini A, Indini A, et al. Association of obesity with survival outcomes in patients with cancer: a systematic review and meta-analysis. JAMA Netw Open. 2021;4(3):e213520–e213520.

Article  PubMed  PubMed Central  Google Scholar 

Schauer DP, Feigelson HS, Koebnick C, et al. Bariatric surgery and the risk of cancer in a large multisite cohort. Ann Surg. 2019;269(1):95–101.

Article  PubMed  Google Scholar 

Mikhailova SV, Ivanoshchuk DE. Innate-immunity genes in obesity. J Personal Med. 2021;11(11):1201.

Article  Google Scholar 

Cerdá C, Sánchez C, Climent B, et al. Oxidative stress and DNA damage in obesity-related tumorigenesis. In: J Camps, editor., et al., Oxidative stress and inflammation in non-communicable diseases: molecular mechanisms and perspectives in therapeutics. Cham: Springer International Publishing; 2014. p. 5–17.

Google Scholar 

Chrysohoou C, Panagiotakos DB, Pitsavos C, et al. The implication of obesity on total antioxidant capacity in apparently healthy men and women: the ATTICA study. Nutr Metab Cardiovasc Dis. 2007;17(8):590–7.

Article  PubMed  Google Scholar 

Griss T, Vincent EE, Egnatchik R, et al. Metformin antagonizes cancer cell proliferation by suppressing mitochondrial-dependent biosynthesis. PLoS Biol. 2015;13(12):e1002309.

Article  PubMed  PubMed Central  Google Scholar 

Chiaradonna F, Sacco E, Manzoni R, Giorgio M, Vanoni M, Alberghina L. Ras-dependent carbon metabolism and transformation in mouse fibroblasts. Oncogene. 2006;25(39):5391–404.

Article  CAS  PubMed  Google Scholar 

Wang D, Bi Y, Hu L, et al. Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS. Cell Commun Signal. 2019;17(1):19.

Article  PubMed  PubMed Central  Google Scholar 

Nevzorova YA, Cubero FJ. Obesity under the moonlight of c-MYC. Front Cell Dev Biol. 2023;11:1293218.

Article  PubMed  PubMed Central  Google Scholar 

Jocken JWE, Blaak EE. Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity. Physiol Behav. 2008;94(2):219–30.

Article  CAS  PubMed  Google Scholar 

Bocian-Jastrzębska A, Malczewska-Herman A, Kos-Kudła B. Role of leptin and adiponectin in carcinogenesis. Cancers. 2023;15(17):4250.

Article  PubMed  PubMed Central  Google Scholar 

Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914–20.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif