Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement

Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659–702.

Article  CAS  PubMed  Google Scholar 

Legler DF, Thelen M. Chemokines: Chemistry, Biochemistry and Biological function. Chimia (Aarau). 2016;70:856–9.

Article  CAS  PubMed  Google Scholar 

Szpakowska M, D’Uonnolo G, Luis R, Alonso Bartolome A, Thelen M, Legler DF, Chevigne A. New pairings and deorphanization among the atypical chemokine receptor family - physiological and clinical relevance. Front Immunol. 2023;14:1133394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comerford I, McColl SR. Atypical chemokine receptors in the immune system. Nat Rev Immunol 2024;10:753-69.

Thelen M, Stein JV. How chemokines invite leukocytes to dance. Nat Immunol. 2008;9:953–9.

Article  CAS  PubMed  Google Scholar 

Legler DF, Thelen M. New insights in chemokine signaling. F1000Res. 2018;7:95.

Article  PubMed  PubMed Central  Google Scholar 

Graham GJ, Locati M, Mantovani A, Rot A, Thelen M. The biochemistry and biology of the atypical chemokine receptors. Immunol Lett. 2012;145:30–8.

Article  CAS  PubMed  Google Scholar 

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, et al. International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine receptors and introducing a New nomenclature for atypical chemokine receptors. Pharmacol Rev. 2014;66:1–79.

Article  PubMed  PubMed Central  Google Scholar 

Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, et al. The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes. Nat Immunol. 2014;15:623–30.

Article  CAS  PubMed  Google Scholar 

Matti C, D’Uonnolo G, Artinger M, Melgrati S, Salnikov A, Thelen S, Purvanov V, Strobel TD, Spannagel L, Thelen M, Legler DF. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4. J Leukoc Biol. 2020;107:1137–54.

Article  CAS  PubMed  Google Scholar 

Meyrath M, Reynders N, Uchanski T, Chevigne A, Szpakowska M. Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22. J Leukoc Biol 2021;109:373-6.

Bryce SA, Wilson RA, Tiplady EM, Asquith DL, Bromley SK, Luster AD, Graham GJ, Nibbs RJ. ACKR4 on stromal cells scavenges CCL19 to enable CCR7-Dependent trafficking of APCs from inflamed skin to Lymph Nodes. J Immunol. 2016;196:3341–53.

Article  CAS  PubMed  Google Scholar 

Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Forster R. Expression of ACKR4 demarcates the peri-marginal sinus, a specialized vascular compartment of the splenic red pulp. Cell Rep. 2021;36:109346.

Article  CAS  PubMed  Google Scholar 

Bastow CR, Bunting MD, Kara EE, McKenzie DR, Caon A, Devi S, Tolley L, Mueller SN, Frazer IH, Harvey N et al. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Proc Natl Acad Sci U S A 2021;118:e2025763118.

Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, et al. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep. 2022;38:110334.

Article  CAS  PubMed  Google Scholar 

Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007;104:14759–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerrits H, van Ingen Schenau DS, Bakker NE, van Disseldorp AJ, Strik A, Hermens LS, Koenen TB, Krajnc-Franken MA, Gossen JA. Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis. 2008;46:235–45.

Article  CAS  PubMed  Google Scholar 

Jamieson T, Cook DN, Nibbs RJ, Rot A, Nixon C, McLean P, Alcami A, Lira SA, Wiekowski M, Graham GJ. The chemokine receptor D6 limits the inflammatory response in vivo. Nat Immunol. 2005;6:403–11.

Article  CAS  PubMed  Google Scholar 

Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, et al. Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol. 2017;18:753–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, Richmond A, Graham GJ, Segerer S, Nibbs RJ, Rot A. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol. 2009;10:101–8.

Article  CAS  PubMed  Google Scholar 

Galliera E, Jala VR, Trent JO, Bonecchi R, Signorelli P, Lefkowitz RJ, Mantovani A, Locati M, Haribabu B. beta-arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem. 2004;279:25590–7.

Article  CAS  PubMed  Google Scholar 

McCulloch CV, Morrow V, Milasta S, Comerford I, Milligan G, Graham GJ, Isaacs NW, Nibbs RJ. Multiple roles for the C-terminal tail of the chemokine scavenger D6. J Biol Chem. 2008;283:7972–82.

Article  CAS  PubMed  Google Scholar 

Zabel BA, Wang Y, Lewen S, Berahovich RD, Penfold ME, Zhang P, Powers J, Summers BC, Miao Z, Zhao B, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009;183:3204–11.

Article  CAS  PubMed  Google Scholar 

Montpas N, St-Onge G, Nama N, Rhainds D, Benredjem B, Girard M, Hickson G, Pons V, Heveker N. Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging. J Biol Chem. 2018;293:893–905.

Article  CAS  PubMed  Google Scholar 

Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ. Vischer HF: beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J Biol Chem. 2013;288:7169–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matti C, Salnikov A, Artinger M, D’Agostino G, Kindinger I, Uguccioni M, Thelen M, Legler DF. ACKR4 recruits GRK3 prior to β-Arrestins but can scavenge chemokines in the absence of β-Arrestins. Front Immunol. 2020;11:720.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakera A, Seeber RM, John AE, Eidne KA, Greaves DR. The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization. Mol Pharmacol. 2008;73:1362–70.

Article  CAS  PubMed  Google Scholar 

Komolov KE, Benovic JL. G protein-coupled receptor kinases: past, present and future. Cell Signal. 2018;41:17–24.

Article  CAS  PubMed  Google Scholar 

Saaber F, Schutz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 regulation of neuronal Migration requires ACKR3 phosphorylation, but not beta-arrestin. Cell Rep. 2019;26:1473–e14881479.

Article  CAS  PubMed  Google Scholar 

Comerford I, Milasta S, Morrow V, Milligan G, Nibbs R. The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. Eur J Immunol. 2006;36:1904–16.

Article  CAS  PubMed  Google Scholar 

Dunn HA, Ferguson SS. PDZ protein regulation of G protein-coupled receptor trafficking and signaling pathways. Mol Pharmacol. 2015;88:624–39.

Article  CAS  PubMed  Google Scholar 

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