Alegre-Abarrategui J, et al. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet. 2009;18(21):4022–34. https://doi.org/10.1093/hmg/ddp346.

Article  PubMed  PubMed Central  Google Scholar 

Altay MF, et al. Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta Neuropathol Commun. 2022;10(1):163. https://doi.org/10.1186/s40478-022-01468-8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Banerjee, A. et al. (2020) ‘Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release’, eLife, 9. https://doi.org/10.7554/eLife.58359.

Banerjee R, et al. Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery. Cells. 2023;12(12):1592. https://doi.org/10.3390/cells12121592.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Behl T, et al. Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives. Int J Mol Sci. 2021;22(3):1413. https://doi.org/10.3390/ijms22031413.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Braak H, Sastre M, Del Tredici K. Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease. Acta Neuropathol. 2007;114:231–41. https://doi.org/10.1007/s00401-007-0244-3.

Article  PubMed  CAS  Google Scholar 

Bruno MA, et al. Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment. J Neuropathol Exp Neurol. 2009;68(12):1309–18. https://doi.org/10.1097/NEN.0b013e3181c22569.

Article  PubMed  CAS  Google Scholar 

Bychkova S, et al. Bafilomycin A1 Molecular Effect on ATPase Activity of Subcellular Fraction of Human Colorectal Cancer and Rat Liver. Int J Mol Sci. 2024;25(3):1657. https://doi.org/10.3390/ijms25031657.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cabezas, R. et al. (2019) ‘Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress.’, Molecular neurobiology, 56(4), pp. 2339–2351. https://doi.org/10.1007/s12035-018-1203-9.

Cao Y, Klionsky DJ. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res. 2007;17(10):839–49. https://doi.org/10.1038/cr.2007.78.

Article  PubMed  CAS  Google Scholar 

Chavarría C, et al. Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons. Biochemical Journal. 2018;475(19):3153–69. https://doi.org/10.1042/BCJ20180297.

Article  PubMed  Google Scholar 

Chen Y-C, et al. Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan. Medicine. 2016;95(5): e2672. https://doi.org/10.1097/MD.0000000000002672.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chinta SJ, Andersen JK. Dopaminergic neurons. Int J Biochem Cell Biol. 2005;37(5):942–6. https://doi.org/10.1016/j.biocel.2004.09.009.

Article  PubMed  CAS  Google Scholar 

Cuervo AM, et al. Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy. Science. 2004;305(5688):1292–5. https://doi.org/10.1126/science.1101738.

Article  PubMed  CAS  Google Scholar 

Datta I, et al. Location and Number of Astrocytes Determine Dopaminergic Neuron Survival and Function Under 6-OHDA Stress Mediated Through Differential BDNF Release. Mol Neurobiol. 2017;55(7):5505–25. https://doi.org/10.1007/s12035-017-0767-0.

Article  PubMed  CAS  Google Scholar 

Dauer W, Przedborski S. Parkinson’s Disease. Neuron. 2003;39(6):889–909. https://doi.org/10.1016/S0896-6273(03)00568-3.

Article  PubMed  CAS  Google Scholar 

De Mattos EP, et al. Protein Quality Control Pathways at the Crossroad of Synucleinopathies. Journal of Parkinson’s Disease. 2020;10(2):369–82. https://doi.org/10.3233/JPD-191790.

Article  PubMed  PubMed Central  Google Scholar 

Deyell JS, et al. The interplay between α-Synuclein and microglia in α-Synucleinopathies. Int J Mol Sci. 2023;24(3):2477. https://doi.org/10.3390/ijms24032477.

Article  PubMed  PubMed Central  CAS  Google Scholar 

di Domenico A, et al. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson’s Disease. Stem Cell Reports. 2019;12:213–29. https://doi.org/10.1016/j.stemcr.2018.12.011.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Di Lella S, et al. When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again. Biochemistry. 2011;50(37):7842–57. https://doi.org/10.1021/bi201121m.

Article  PubMed  CAS  Google Scholar 

Dilsizoglu Senol A, et al. ‘α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes’, PLOS Biology. Edited by S A Tooze. 2021;19(7): e3001287. https://doi.org/10.1371/journal.pbio.3001287.

Article  CAS  Google Scholar 

Ebrahimi-Fakhari D, et al. Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein. J Neurosci. 2011;31(41):14508–20. https://doi.org/10.1523/JNEUROSCI.1560-11.2011.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Emin D, et al. Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease. Nat Commun. 2022;13(1):5512. https://doi.org/10.1038/s41467-022-33252-6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Emmanouilidou E, Stefanis L, Vekrellis K. Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome. Neurobiol Aging. 2010;31(6):953–68. https://doi.org/10.1016/j.neurobiolaging.2008.07.008.

Article  PubMed  CAS  Google Scholar 

Erustes AG, et al. Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis. J Neurosci Res. 2018;96(1):160–71. https://doi.org/10.1002/jnr.24092.

Article  PubMed  CAS  Google Scholar 

Fairbanks G, et al. Protein kinases and membrane protein phosphorylation in normal and abnormal human erythrocytes: variation related to mean cell age. Blood. 1983;61(5):850–7. https://doi.org/10.1182/blood.V61.5.850.850.

Article  PubMed  CAS  Google Scholar 

Ferrari, D. C. et al. (2012) ‘Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups’, Frontiers in Cellular Neuroscience, 6. https://doi.org/10.3389/fncel.2012.00007.

Fields CR, Bengoa-Vergniory N, Wade-Martins R. Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease. Front Mol Neurosci. 2019;12(December):1–14. https://doi.org/10.3389/fnmol.2019.00299.

Article  CAS  Google Scholar 

Figueroa XF, et al. Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels. Neuropharmacology. 2013;75:471–8. https://doi.org/10.1016/j.neuropharm.2013.02.022.

Article  PubMed  CAS  Google Scholar 

Forno LS. Neuropathology of Parkinsonʼs Disease. J Neuropathol Exp Neurol. 1996;55(3):259–72. https://doi.org/10.1097/00005072-199603000-00001.

Article