The role of vitamin D in the prevention and treatment of tuberculosis: a meta-analysis of randomized controlled trials

WHO.: Global tuberculosis report, 2021. . Geneva: World Health Oranization, 2021 2021.

Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, Lillebaek T, Andersen AB, Wejse CM, Dahl VN. Global treatment outcomes of extensively drug-resistant tuberculosis in adults: a systematic review and meta-analysis. J Infect. 2023;87(3):177–89.

Article  CAS  PubMed  Google Scholar 

Balla M, Merugu GP, Konala VM, Sangani V, Kondakindi H, Pokal M, Gayam V, Adapa S, Naramala S, Malayala SV. Back to basics: review on vitamin D and respiratory viral infections including COVID-19. J Community Hospital Internal Med Perspectives. 2020;10(6):529–36.

Article  Google Scholar 

Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: a systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3(4):300–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goyal JP, Singh S, Bishnoi R, Bhardwaj P, Kaur RJ, Dhingra S, Yadav D, Dutta S, Charan J. Efficacy and safety of vitamin D in tuberculosis patients: a systematic review and meta-analysis. Expert Rev Anti Infect Ther. 2022;20(7):1049–59.

Article  CAS  PubMed  Google Scholar 

Byndoor Y, Sagar TV, Patil RH, Veeraiah D. Vitamin D as supplementary treatment for newly diagnosed pulmonary tuberculosis patients. Res J Pharmacy Technol. 2023;16(10):4924–8.

Article  Google Scholar 

Chandra H, Rahman A, Yadav P, Maurya G, Kumar Shukla S. Effect of adjunct Vitamin D treatment in vitamin D deficient pulmonary tuberculosis patients: a randomized, double blind, active controlled clinical trial. Indian J Tuberc. 2024;71(2):170–8.

Article  PubMed  Google Scholar 

Hussain MI, Ibtisam R, Fatima T, Khalid H, Aziz A, Khansa SA, Shahzad A, Jabeen A. The role of vitamin D supplementation in augmenting IFN-γ production in response to mycobacterium tuberculosis Infection: A randomized controlled trial. Pakistan J Pharmaceutical Sci. 2023;36(6):1901–8.

CAS  Google Scholar 

Sinha S, Thukral H, Shareef I, Desai D, Singh BK, Das BK, Dhooria S, Sarin R, Singla R, Meena SK, et al. Prevention of relapse in drug sensitive pulmonary tuberculosis patients with and without vitamin D3 supplementation: a double blinded randomized control clinical trial. PLoS ONE. 2023;18(3): e0272682.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamara L, Kartasasmita CB, Alam A, Gurnida DA. Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: a randomized double-blind controlled trial in Indonesia. J Glob Health. 2022;12:04015.

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg (London, England). 2021;88: 105906.

Article  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ (Clin Res ed). 2019;366: l4898.

Google Scholar 

Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: a new series of articles in the journal of clinical epidemiology. J Clin Epidemiol. 2011;64(4):380–2.

Article  PubMed  Google Scholar 

Wejse C, Gomes VF, Rabna P, Gustafson P, Aaby P, Lisse IM, Andersen PL, Glerup H, Sodemann M. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2009;179(9):843–50.

Article  CAS  PubMed  Google Scholar 

Wejse C, Gustafson P, Nielsen J, Gomes VF, Aaby P, Andersen PL, Sodemann M. TBscore: Signs and symptoms from tuberculosis patients in a low-resource setting have predictive value and may be used to assess clinical course. Scand J Infect Dis. 2008;40(2):111–20.

Article  PubMed  Google Scholar 

Ganmaa D, Giovannucci E, Bloom BR, Fawzi W, Burr W, Batbaatar D, Sumberzul N, Holick MF, Willett WC. Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial. Am J Clin Nutr. 2012;96(2):391–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, Khulan D, Ariunzaya S, Sumiya E, Bolortuya B, et al. Vitamin D supplements for prevention of tuberculosis infection and disease. N Engl J Med. 2020;383(4):359–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Middelkoop K, Stewart J, Walker N, Delport C, Jolliffe DA, Coussens AK, Nuttall J, Tang JCY, Fraser WD, Griffiths CJ, et al. Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicenter phase 3 double-blind randomized placebo-controlled trial (ViDiKids). Int J Infectious Diseases: IJID: Off Publication Int Soc Infectious Diseases. 2023;134:63–70.

CAS  Google Scholar 

Sudfeld CR, Mugusi F, Muhihi A, Aboud S, Nagu TJ, Ulenga N, Hong B, Wang M, Fawzi WW. Efficacy of vitamin D(3) supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial. The lancet HIV. 2020;7(7):e463–71.

Article  PubMed  PubMed Central  Google Scholar 

Afzal A, Rathore R, Butt NF, Randhawa FA. Efficacy of Vitamin D supplementation in achieving an early sputum conversion in smear positive pulmonary tuberculosis. Pakistan J Med Sci. 2018;34(4):849–54.

Google Scholar 

Bekele A, Gebreselassie N, Ashenafi S, Kassa E, Aseffa G, Amogne W, Getachew M, Aseffa A, Worku A, Raqib R, et al. Daily adjunctive therapy with vitamin D(3) and phenylbutyrate supports clinical recovery from pulmonary tuberculosis: a randomized controlled trial in Ethiopia. J Intern Med. 2018;284(3):292–306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daley P, Jagannathan V, John KR, Sarojini J, Latha A, Vieth R, Suzana S, Jeyaseelan L, Christopher DJ, Smieja M, et al. Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2015;15(5):528–34.

Article  CAS  PubMed  Google Scholar 

Farazi A, Didgar F, Sarafraz A. The effect of vitamin D on clinical outcomes in tuberculosis. Egyptian J Chest Diseases Tuberc. 2017;66(3):419–23.

Article  Google Scholar 

Ganmaa D, Munkhzul B, Fawzi W, Spiegelman D, Willett WC, Bayasgalan P, Baasansuren E, Buyankhishig B, Oyun-Erdene S, Jolliffe DA, et al. High-dose vitamin D(3) during tuberculosis treatment in mongolia a randomized controlled trial. Am J Respiratory Critical Care Med. 2017;196(5):628–37.

Article  CAS  Google Scholar 

Hasanain AFA, Zayed AAH, Abd-Ellatief RB, Nafee AMA. Efficacy and safety of cholecalciferol-augmented anti-tuberculosis therapy for treatment of naïve patients with pulmonary tuberculosis: A randomized, controlled, clinical study. Indian J Tuberc. 2019;66(1):111–7.

Article  PubMed  Google Scholar 

Kr Singh A, Gogoi JB, Pant NC, Mittal P, Juyal V, Mukherjee S. A study on the role of vitamins and minerals supplementation in the treatment of tuberculosis. Indian J Public Health Res Develop. 2013;4(2):26–30.

Article  Google Scholar 

Kumar BYP, Praveen D, Chowdary PR, Aanandhi MV. A prospective single-blinded study on safety and efficacy of cholecalciferol supplementation in pulmonary tuberculosis. Drug Invention Today. 2019;12(11):2553–7.

Google Scholar 

Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, Packe GE, Moore-Gillon JC, Darmalingam M, Davidson RN, et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet (London, England). 2011;377(9761):242–50.

Article  CAS  PubMed  Google Scholar 

Mily A, Rekha RS, Kamal SM, Arifuzzaman AS, Rahim Z, Khan L, Haq MA, Zaman K, Bergman P, Brighenti S, et al. Significant effects of oral phenylbutyrate and vitamin D3 adjunctive therapy in pulmonary tuberculosis: a randomized controlled trial. PLoS ONE. 2015;10(9): e0138340.

Article  PubMed  PubMed Central  Google Scholar 

Nursyam EW, Amin Z, Rumende CM. The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med Indones. 2006;38(1):3–5.

PubMed  Google Scholar 

Ralph AP, Waramori G, Pontororing GJ, Kenangalem E, Wiguna A, Tjitra E, Sandjaja LDB, Yeo TW, Chatfield MD, et al. L-arginine and vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial. PLoS ONE. 2013;8(8):e70032.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis. BMC Infect Dis. 2013;13:22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tukvadze N, Sanikidze E, Kipiani M, Hebbar G, Easley KA, Shenvi N, Kempker RR, Frediani JK, Mirtskhulava V, Alvarez JA, et al. High-dose vitamin D3 in

留言 (0)

沒有登入
gif