Schneider SA, Obeso JA. Clinical and pathological features of Parkinson’s disease. Curr Top Behav Neurosci. 2015;22:205–20.

Article  CAS  PubMed  Google Scholar 

Elsayed I, Martinez-Carrasco A, Cornejo-Olivas M, Bandres-Ciga S. Mapping the diverse and inclusive future of Parkinson’s disease genetics and its widespread impact. Genes. 2021;12(11):1681–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Miranda BR, Goldman SM, Miller GW, Greenamyre JT, Dorsey ER. Preventing Parkinson’s disease: an environmental agenda. J Parkinsons Dis. 2022;12(1):45–68.

Article  PubMed  PubMed Central  Google Scholar 

Barba L, Paolini PF, Bellomo G, Gaetani L, Halbgebauer S, Oeckl P, Otto M, Parnetti L. Alpha and beta synucleins: from pathophysiology to clinical application as biomarkers. Mov Disord. 2022;37(4):669–83.

Article  PubMed  PubMed Central  Google Scholar 

Burré J, Sharma M, Südhof TC. Cell biology and pathophysiology of α-synuclein. Cold Spring Harb Perspect Med. 2018;8(3): a024091.

Article  PubMed  PubMed Central  Google Scholar 

Villar-Piqué A, LopesdaFonseca T, Outeiro TF. Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies. J Neurochem. 2016;139(S1):240–55.

Article  PubMed  Google Scholar 

Sulzer D, Edwards RH. The physiological role of α-synuclein and its relationship to Parkinson’s Disease. J Neurochem. 2019;150(5):475–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarchione A, Marchand A, Taymans JM, Chartier-Harlin MC. Alpha-synuclein and lipids: the elephant in the room? Cells. 2021;10(9):2452.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zella MAS, Metzdorf J, Ostendorf F, Maass F, Muhlack S, Gold R, Haghikia A, Tönges L. Novel immunotherapeutic approaches to target alpha-synuclein and related neuroinflammation in Parkinson’s disease. Cells. 2019;8(2):105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lesage S, Anheim M, Letournel F, Bousset L, Honoré A, Rozas N, Pieri L, Madiona K, Dürr A, Melki R, Verny C, Brice A. G51D α-synuclein mutation causes a novel Parkinsonian–pyramidal syndrome. Ann Neurol. 2013;73(4):459–71.

Article  CAS  PubMed  Google Scholar 

Pasanen P, Myllykangas L, Siitonen M, Raunio A, Kaakkola S, Lyytinen J, Tienari PJ, Pöyhönen M, Paetau A. A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson’s disease-type pathology. Neurobiol Aging. 2014;35(9):2180–5.

Article  Google Scholar 

Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Mutation in the α-synuclein gene identified in families with Parkinson’s disease. Science. 1997;276(5321):2045–7.

Article  CAS  PubMed  Google Scholar 

Zarranz JJ, Alegre J, Gómez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atarés B, Llorens V, Gomez Tortosa E, del Ser T, Muñoz DG, de Yebenes JG. The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia. Ann Neurol. 2004;55(2):164–73.

Article  CAS  PubMed  Google Scholar 

Appel-Cresswell S, Vilarino-Guell C, Encarnacion M, Sherman H, Yu I, Shah B, Weir D, Thompson C, Szu-Tu C, Trinh J, Aasly JO, Rajput A, Rajput AH, Jon Stoessl A, Farrer MJ. Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson’s disease. Mov Disord. 2013;28(6):811–3.

Article  CAS  PubMed  Google Scholar 

Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O. AlaSOPro mutation in the gene encoding α-synuclein in Parkinson’s disease. Nat Genet. 1998;18(2):106–8.

Article  PubMed  Google Scholar 

Farrer M, Kachergus J, Forno L, Lincoln S, Wang DS, Hulihan M, Maraganore D, Gwinn-Hardy K, Wszolek Z, Dickson D, Langston JW. Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications. Ann Neurol. 2004;55(2):174–9.

Article  CAS  PubMed  Google Scholar 

Singleton A, Gwinn-Hardy K, Sharabi Y, Li S, Holmes C, Dendi R, Hardy J, Singleton A, Crawley A, Goldstein DS. Association between cardiac denervation and Parkinsonism caused by α-synuclein gene triplication. Brain. 2004;127(4):768–72.

Article  PubMed  Google Scholar 

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J, 23andMe Research Team, Eerola-Rautio J, Tienari P, Majamaa K, Toft M, Grosset DG, Gasser T, Heutink P, Shulman JM, Wood N, Hardy J, Morris HR, Hinds DA, Gratten J, Visscher PM, Gan-Or Z, Nalls MA, Singleton AB. Parkinson’s disease age at onset genome-wide association study: defining heritability, genetic loci, and α-synuclein mechanisms. Mov Disord. 2019;34(6):866–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gámez-Valero A, Beyer K. Alternative splicing of alpha- and beta-synuclein genes plays differential roles in synucleinopathies. Genes. 2018;9(2):63.

Article  PubMed  PubMed Central  Google Scholar 

Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B. The role of alpha-synuclein and other Parkinson’s genes in neurodevelopmental and neurodegenerative disorders. Int J Mol Sci. 2020;21(16):5724.

Article  PubMed  PubMed Central  Google Scholar 

Srinivasan E, Chandrasekhar G, Chandrasekar P, Anbarasu K, Vickram AS, Karunakaran R, Rajasekaran R, Srikumar PS. Alpha-synuclein aggregation in Parkinson’s disease. Front Med. 2021;8: 736978.

Article  CAS  Google Scholar 

Tolosa E, Garrido A, Scholz SW, Poewe W. Challenges in the diagnosis of Parkinson’s disease. Lancet Neurol. 2021;20(5):385–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goedert M, Spillantini MG, Del Tredici K, Braak H. 100 years of Lewy pathology. Nat Rev Neurol. 2013;9(1):13–24.

Article  CAS  PubMed  Google Scholar 

Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, Marras C, Tanner CM, Ross GW, Langston JW, Klein C, Bonifati V, Jankovic J, Lozano AM, Deuschl G, Bergman H, Tolosa E, Rodriguez-Violante M, Fahn S, Postuma RB, Berg D, Marek K, Standaert DG, Surmeier DJ, Olanow CW, Kordower JH, Calabresi P, Schapira AHV, Stoessl AJ. Past, present, and future of Parkinson’s disease: a special essay on the 200th Anniversary of the Shaking Palsy. Mov Disord. 2017;32(9):1264–310.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lo C, Arora S, Ben-Shlomo Y, Barber TR, Lawton M, Klein JC, Kanavou S, Janzen A, Sittig E, Oertel WH, Grosset DG, Hu MT. Olfactory testing in Parkinson disease and REM behavior disorder: a machine learning approach. Neurology. 2021;96(15):e2016–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pont-Sunyer C, Hotter A, Gaig C, Seppi K, Compta Y, Katzenschlager R, Mas N, Hofeneder D, Brücke T, Bayés A, Wenzel K, Infante J, Zach H, Pirker W, Posada IJ, Álvarez R, Ispierto L, De Fàbregues O, Callén A, Palasí A, Aguilar M, Martí MJ, Valldeoriola F, Salamero M, Poewe W, Tolosa E. The onset of nonmotor symptoms in Parkinson’s disease (The ONSET PD Study). Mov Disord. 2015;30(2):229–37.

Article  PubMed  Google Scholar 

Hawkes CH, Del Tredici K, Braak H. Parkinson’s disease. Ann N Y Acad Sci. 2009;1170(1):615–22.

Article  PubMed  Google Scholar 

Hawkes CH, Del Tredici K, Braak H. Parkinson’s disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol. 2007;33(6):599–614.

Article  CAS  PubMed  PubMed Central  Google Scholar