Powell EE, Wong VW, Rinella M. Non-alcoholic fatty liver disease. Lancet. 2021;397:2212–24.

Article  CAS  PubMed  Google Scholar 

Dharmalingam M, Yamasandhi PG. Nonalcoholic fatty liver disease and Type 2 diabetes mellitus. Indian J Endocrinol Metab. 2018;22:421–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bril F, Cusi K. Management of nonalcoholic fatty liver disease in patients with type 2 diabetes: a call to action. Diabetes Care. 2017;40:419–30.

Article  PubMed  Google Scholar 

Hazlehurst JM, Woods C, Marjot T, Cobbold JF, Tomlinson JW. Non-alcoholic fatty liver disease and diabetes. Metabolism. 2016;65:1096–108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C, et al. Pyroptosis in inflammatory diseases and cancer. Theranostics. 2022;12:4310–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu J, Lin S, Wan B, Velani B, Zhu Y. Pyroptosis in liver disease: new insights into disease mechanisms. Aging Dis. 2019;10:1094–108.

Article  PubMed  PubMed Central  Google Scholar 

Hao YY, Cui WW, Gao HL, Wang MY, Liu Y, Li CR, et al. Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis. Pharm Biol. 2022;60:274–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Wu H, Wu R, Tan Y, Chang Q. Application of multiple machine learning approaches to determine key pyroptosis molecules in type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2023;14:1112507.

Article  PubMed  Google Scholar 

Kwon SG, Kwon YW, Lee TW, Park GT, Kim JH. Recent advances in stem cell therapeutics and tissue engineering strategies. Biomater Res. 2018;22:36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mebarki M, Abadie C, Larghero J, Cras A. Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products. Stem Cell Res Ther. 2021;12:152.

Article  PubMed  PubMed Central  Google Scholar 

Liu M, He J, Zheng S, Zhang K, Ouyang Y, Zhang Y, et al. Human umbilical cord mesenchymal stem cells ameliorate acute liver failure by inhibiting apoptosis, inflammation and pyroptosis. Ann Transl Med. 2021;9:1615.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li B, Cheng Y, Yu S, Zang L, Yin Y, Liu J, et al. Human umbilical cord-derived mesenchymal stem cell therapy ameliorates nonalcoholic fatty liver disease in obese type 2 diabetic mice. Stem Cells Int. 2019;2019:8628027.

Article  PubMed  PubMed Central  Google Scholar 

Liang ZH, Lin SS, Pan NF, Zhong GY, Qiu ZY, Kuang SJ, et al. UCMSCs-derived exosomal circHIPK3 promotes ulcer wound angiogenesis of diabetes mellitus via miR-20b-5p/Nrf2/VEGFA axis. Diabet Med. 2023;40:e14968.

Article  CAS  PubMed  Google Scholar 

Katsuda T, Kosaka N, Takeshita F, Ochiya T. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics. 2013;13:1637–53.

Article  CAS  PubMed  Google Scholar 

van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28.

Article  PubMed  Google Scholar 

Ebrahim N, Mostafa O, El Dosoky RE, Ahmed IA, Saad AS, Mostafa A, et al. Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model. Stem Cell Res Ther. 2018;9:175.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu CX, Chen LL. Circular RNAs: characterization, cellular roles, and applications. Cell. 2022;185:2016–34.

Article  CAS  PubMed  Google Scholar 

Ruan ZB, Chen GC, Zhang R, Zhu L. Circular RNA expression profiles during the differentiation of human umbilical cord-derived mesenchymal stem cells into cardiomyocyte-like cells. J Cell Physiol. 2019;234:16412–23.

Article  CAS  PubMed  Google Scholar 

Wu L, Xiong L, Li J, Peng Z, Zhang L, Shi P, et al. Circ-Tulp4 promotes beta-cell adaptation to lipotoxicity by regulating soat1 expression. J Mol Endocrinol. 2020;65:149–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma X, Chen H, Li L, Yang F, Wu C, Tao K. CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition. J Exp Clin Cancer Res. 2021;40:330.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lagunas-Rangel FA. KDM6B (JMJD3) and its dual role in cancer. Biochimie. 2021;184:63–71.

Article  CAS  PubMed  Google Scholar 

Bi Z, Liu Y, Zhao Y, Yao Y, Wu R, Liu Q, et al. A dynamic reversible RNA N(6) -methyladenosine modification: current status and perspectives. J Cell Physiol. 2019;234:7948–56.

Article  CAS  PubMed  Google Scholar 

Cai Y, Chen T, Wang M, Deng L, Li C, Fu S, et al. N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway. Diabetes Res Clin Pract. 2023;197:110261.

Article  CAS  PubMed  Google Scholar 

Cao JK, Kaplan J, Stella N. ABHD6: Its Place in Endocannabinoid Signaling and Beyond. Trends Pharmacol Sci. 2019;40:267–77.

Article  PubMed  PubMed Central  Google Scholar 

Li R, Ye Z, She D, Fang P, Zong G, Hu K, et al. Semaglutide may alleviate hepatic steatosis in T2DM combined with NFALD mice via miR-5120/ABHD6. Drug Des Devel Ther. 2022;16:3557–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

In: Guide for the Care and Use of Laboratory Animals. 8th edn. Washington (DC); 2011.

Chen W, Zhang F, Hou X, Xu H, Tang D. Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis. Cell Commun Signal. 2022;20:28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Bai Y, Han B, Ju M, Tang T, Shen L, et al. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. J Extracell Vesicles. 2022;11:e12185.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin Y, Hao H, Cheng Y, Zang L, Liu J, Gao J, et al. Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice. Cell Death Dis. 2018;9:760.

Article  PubMed  PubMed Central  Google Scholar 

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–8.

Article  CAS  PubMed  Google Scholar 

Liu D, Luo X, Xie M, Zhang T, Chen X, Zhang B, et al. HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression. Cancer Sci. 2022;113:3347–61.

Article