Hubalek Z. Epidemiology of Lyme Borreliosis. Curr Probl Dermatol. 2009;37:31–50. https://doi.org/10.1159/000213069.

Article  PubMed  Google Scholar 

Wilking H, et Stark K. Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany, 2009–2012. Ticks Tick Borne Dis. 2014;5(3):219–24. https://doi.org/10.1016/j.ttbdis.2013.10.010.

Article  PubMed  Google Scholar 

Rauer S, Kastenbauer S et al. Guidelines for diagnosis and treatment in neurology– Lyme neuroborreliosis. Ger Med Sci. 2020; 18: Doc03. https://doi.org/10.3205/000279

Gilden D, Cohrs RJ, Mahalingam R, Nagel MA. Neurological Disease produced by Varicella Zoster Virus Reactivation without Rash. Curr Top Microbiol Immunol. 2010;342:243–53. https://doi.org/10.1007/82_2009_3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stanek G, et Strle F, Pfister HW. Lyme borreliosis. Lancet (2009): What are the indications for lumbar puncture in patients with Lyme disease? Curr Probl Dermatol 2009; 37: 200–206. https://doi.org/10.1159/000213078

Lohr B, Fingerle V, Norris DE, Hunfeld K-P. Laboratory diagnosis of Lyme borreliosis: current state of art and future perspectives. Crit Rev Clin Lab Sci. 2018;55(4):219–45. https://doi.org/10.1080/10408363.2018.1450353.

Article  PubMed  Google Scholar 

Lakos A, Reiczigel J, Solymosi N. The positive predictive value of Borrelia burgdorferi serology in the light of symptoms of patients sent to an outpatient service for tick-borne diseases. Inflamm Res. 2010;59(11):959–64. https://doi.org/10.1007/s00011-010-0209-1.

Article  CAS  PubMed  Google Scholar 

Mygland A, et al. EFNS guidelines on the diagnosis and management on European Lyme neuroborreliosis. Eur J Neurol. 2010;17(1):8–16. https://doi.org/10.1111/j.1468-1331.2009.02862.x.

Article  CAS  PubMed  Google Scholar 

Rupprecht TA, Koedel U, Angele B, Fingerle V, Pfister HW. Cytokine CXCL13–a possible early CSF marker for neuroborreliosis. Nervenarzt. 2006;77(4):470–3. https://doi.org/10.1007/s00115-005-2021-7.

Article  CAS  PubMed  Google Scholar 

von Baehr V, Doebis C, Volk HD, von Baehr R. The lymphocyte transformation test for borrelia detects active lyme borreliosis and verifies effective antibiotic treatment. Open Neurol J. 2012;6:104–12. https://doi.org/10.2174/1874205X01206010104.

Article  Google Scholar 

Dessau RB, Fingerle V, Gray J et al. The lymphocyte transformation test for the diagnosis of Lyme borreliosis has currently not been shown to be clinically useful. Clin Microbiol Infect. 2014;20(10):786-7. https://doi.org/10.1111/1469-0691.12583

Rupprecht TA, Manz KM, Fingerle V, et al. Diagnostic value of cerebrospinal fluid CXCL13 for acute Lyme neuroborreliosis. A systematic review and meta-analysis. Clin Microbiol Infect. 2018;24(12):1234–40. https://doi.org/10.1016/j.cmi.2018.04.007.

Article  CAS  PubMed  Google Scholar 

Baarsma ME, van de Schoor FR, Gauw SA, et al. Diagnostic parameters of cellular tests for Lyme borreliosis in Europe (VICTORY study): a case-control study. Lancet Infect Dis. 2022;22:1388–96. https://doi.org/10.1016/S1473-3099(22)00205-5.

Article  CAS  PubMed  Google Scholar 

Vaz A, Glickstein L, Field JA, et al. Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease. Infect Immun. 2001;69(12):7437–44. https://doi.org/10.1128/IAI.69.12.7437-7444.2001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dressler F, Yoshinari NH, Steere AC. The T-cell proliferative assay in the diagnosis of Lyme disease. Ann Intern Med. 1991;115(7):533–9. https://doi.org/10.7326/0003-4819-115-7-533.

Article  CAS  PubMed  Google Scholar 

Wojciechowska-Koszko I, Kwiatkowski P, Sienkiewicz M, Kowalczyk M, Kowalczyk E, Dołęgowska B. Cross-Reactive Results in Serological Tests for Borreliosis in Patients with Active Viral Infections.

Hammond S, Thomson P, Meng X, Naisbitt D. In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. In: Front Immunol. 2021; https://doi.org/10.3389/fimmu.2021.630530

Schempp C, Owsianowski M, Lange R, Gollnick H. Comparison of Borrelia burgdorferi ultrasonicate and whole B, burgdorferi cells as a stimulus for T-cell proliferation and GM-CSF secretion in vitro. Zentralbl Bakteriol. 1993;279(3):417–25. https://doi.org/10.1016/s0934-8840(11)80374-9.

Article  CAS  PubMed  Google Scholar 

Tilly K, Patricia AR, Stewart PE. Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am. 2008;22(2):217–34. https://doi.org/10.1016/j.idc.2007.12.013.

Article  PubMed  PubMed Central  Google Scholar 

Anderson C, Brissette C. The brilliance of Borrelia: mechanisms of host Immune Evasion by Lyme Disease-causing spirochetes. Pathogens. 2021;10(3):281. https://doi.org/10.3390/pathogens10030281.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forsberg P, Ernerudh J, Ekerfelt C, Roberg M, Vrethem M, Bergström S. The outer surface proteins of Lyme disease borrelia spirochetes stimulate T cells to secrete interferon-gamma (IFN-gamma): diagnostic and pathogenic implications. Clin Exp Immunol. 1995;101(3):453–60. https://doi.org/10.1111/j.1365-2249.1995.tb03134.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ekerfelt C, Ernerudh J, Bunikis J, et al. Compartmentalization of antigen specific cytokine responses to the central nervous system in CNS borreliosis: secretion of IFN-gamma predominates over IL-4 secretion in response to outer surface proteins of Lyme disease Borrelia spirochetes. J Neuroimmunol. 1997;79(2):155–62. https://doi.org/10.1016/s0165-5728(97)00118-5.

Article  CAS  PubMed  Google Scholar 

van Gorkom T, Sankatsing SUC, Voet W, et al. An enzyme-linked Immunosorbent Spot Assay Measuring Borrelia burgdorferi B31-Specific Interferon Gamma-secreting T cells cannot discriminate active Lyme Neuroborreliosis from Past Lyme Borreliosis: a prospective study in the Netherlands. J Clin Microbiol. 2018;56(4):e01695–17. https://doi.org/10.1128/JCM.01695-17.

Article  PubMed  PubMed Central  Google Scholar 

Hörstrup P, Ackermann R. Tick born meningopolyneuritis (Garin-Bujadoux, Bannwarth) (author’s transl). Fortschr Neurol Psychiatr Grenzgeb. 1973;41(11):583–606.

PubMed  Google Scholar 

Rupprecht TA, Koedel U, Fingerle V, Pfister HW. The pathogenesis of lyme neuroborreliosis: from infection to inflammation. Mol Med. 2008;14(3–4):205–12. https://doi.org/10.2119/2007-00091.Rupprecht.

Article  CAS  PubMed  Google Scholar 

Rupprecht TA, et al. Adhesion of Borrelia garinii to neuronal cells is mediated by the interaction of OspA with proteoglycans. J Neuroimmunol. 2006;175(1–2):5–11. https://doi.org/10.1016/j.jneuroim.2006.02.007.

Article  CAS  PubMed  Google Scholar 

Camponovo F, et Meier C. Neuropathy of vasculitic origin in a case of Garin-Boujadoux-Bannwarth syndrome with positive borrelia antibody response. J Neurol. 1986;233(2):69–72. https://doi.org/10.1007/BF00313849.

Article  CAS  PubMed  Google Scholar 

Ubogu EE. Biology of the human blood-nerve barrier in health and disease. Exp Neurol. 2020;328:Artikel113272. https://doi.org/10.1016/j.expneurol.2020.113272

Baranton G, de Martino SJ. Borrelia burgdorferi sensu lato diversity and its influence on pathogenicity in humans. Curr Probl Dermtol. 2009;37:1–17. https://doi.org/10.1159/000213066.

Article  Google Scholar