Pishavar E, Luo H, Naserifar M, et al. Advanced hydrogels as exosome delivery systems for osteogenic differentiation of MSCs: application in bone regeneration. Int J Mol Sci. 2021;22(12):6203.

Article  PubMed  PubMed Central  Google Scholar 

Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet (London, England). 2002;359:1761–7.

Article  PubMed  Google Scholar 

Xiao PL, Cui AY, Hsu CJ, et al. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporos Int. 2022;33(10):2137–53.

Article  PubMed  Google Scholar 

Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726–33.

Article  PubMed  Google Scholar 

Hernlund E, Svedbom A, Ivergård M et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). 2013; Arch Osteopor 8:136;

Gourlay ML, Brown SA. Clinical considerations in premenopausal osteoporosis. Arch Internal Med. 2004;164:603–14.

Article  Google Scholar 

Yang P, Zhou J, Ai Q, et al. Comparison of Individual Tissue-Engineered Bones and Allogeneic Bone in Treating Bone Defects: A Long-Term Follow-Up Study. Cell Transplant. 2020 Jan-Dec;29:963689720940722;

Malek F, Krueger P, Hatmi ZN, et al. Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy. Int Orthop. 2006;30(6):495–8.

Article  PubMed  PubMed Central  Google Scholar 

Roudbari S, Haji Aliloo Sami S, Roudbari M. The clinical results of benign bone tumor treatment with allograft or autograft. Arch Iran Med. 2015;18(2):109–113

Donos N, Akcali A, Padhye N, et al. Bone regeneration in implant dentistry: Which are the factors affecting the clinical outcome?. Periodontol 2000. 2023;93(1):26–55;

Majidinia M, Sadeghpour A, Yousefi B. The roles of signaling pathways in bone repair and regeneration. J Cell Physiol. 2018;233(4):2937–48.

Article  PubMed  Google Scholar 

Salhotra A, Shah HN, Levi B, et al. Mechanisms of bone development and repair. Nat Rev Mol Cell Biol. 2020;21(11):696–711.

Article  PubMed  PubMed Central  Google Scholar 

Xiao D, Zhang J, Zhang C, et al. The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved. Acta Biomater. 2020;106:22–33.

Article  PubMed  Google Scholar 

Summers BN, Eisenstein SM. Donor site pain from the ilium. A complication of lumbar spine fusion. J Bone Joint Surg Br. 1989; 71:677–680;

Gazdag AR, Lane JM, Glaser D, Forster RA. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Surg. 1995;3:1–8.

Article  PubMed  Google Scholar 

Pirosa A, Gottardi R, Alexander PG, et al. Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology. Stem Cell Res Ther. 2018;9(1):112.

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, He J, Qiu T, et al. Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases. Stem Cell Res Ther. 2022;13(1):201.

Article  PubMed  PubMed Central  Google Scholar 

Tan SHS, Wong JRY, Sim SJY, et al. Mesenchymal stem cell exosomes in bone regenerative strategies-a systematic review of preclinical studies. Mater Today Bio. 2020;7:100067.

Article  PubMed  PubMed Central  Google Scholar 

Huber J, Griffin MF, Longaker MT, Quarto N. Exosomes: a tool for bone tissue engineering. Tissue Eng Part B Rev. 2022;28(1):101–13.

Article  PubMed  PubMed Central  Google Scholar 

Kalluri, R., and LeBleu, V. S. (2020). The biology, function, and biomedical applications of exosomes. Science 367 (6478), eaau6977;

Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther. 2023;14(1):66.

Article  PubMed  PubMed Central  Google Scholar 

Zhou C, Zhang B, Yang Y, et al. Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing. Stem Cell Res Ther. 2023;14(1):107.

Article  PubMed  PubMed Central  Google Scholar 

Kobayashi T, Chanmee T, Itano N. Hyaluronan: metabolism and function. Biomolecules. 2020;10(11):1525.

Article  PubMed  PubMed Central  Google Scholar 

He L, He T, Xing J, et al. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 2020;11(1):276.

Article  PubMed  PubMed Central  Google Scholar 

Ma S, Zhang Y, Li S, et al. Engineering exosomes for bone defect repair. Front Bioeng Biotechnol. 2022;7(10):1091360.

Article  Google Scholar 

Wei Y, Ma H, Zhou H, et al. miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt/β-catenin axis. Aging (Albany NY). 2021;13(13):17190–201.

Article  PubMed  Google Scholar 

Lin Z, Xiong Y, Meng W, et al. Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant. Bioact Mater. 2021;3(13):300–11.

Google Scholar 

Hade MD, Suire CN, Suo Z. Mesenchymal stem cell-derived exosomes: applications in regenerative medicine. Cells. 2021;10(8):1959.

Article  PubMed  PubMed Central  Google Scholar 

Yang D, Zhang W, Zhang H, et al. Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics. Theranostics. 2020;10(8):3684–707.

Article  PubMed  PubMed Central  Google Scholar 

Gurunathan S, Kang MH, Jeyaraj M, et al. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells. 2019;8:307.

Article  PubMed  PubMed Central  Google Scholar 

Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255.

Article  PubMed  Google Scholar 

Poon IKH, Parkes MAF, Jiang L et al. Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles in vitro. J Extracell Vesicles 8, 2019;

Zhu Y, Crowley SC, Latimer AJ, et al. Migratory neural crest cells phagocytose dead cells in the developing nervous system. Cell. 2019;179:74-89.e10.

Article  PubMed  PubMed Central  Google Scholar 

Brock CK, Wallin ST, Ruiz OE et al. Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Nat Commun; 2019; 10:1044;

Jiang L, Paone S, Caruso S, et al. Determining the contents and cell origins of apoptotic bodies by flow cytometry. Sci Rep. 2017;7:1–12.

Article  Google Scholar 

van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.

Article  PubMed  Google Scholar 

Casado-Dı´az, A., Quesada-Go´mez, J.M., and Dorado, G. Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: applications in skin wound healing. Front Bioeng Biotechnol 8, 146, 2020;

Wang X, Omar O, Vazirisani F, et al. Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation. PLoS ONE. 2018;13:e0193059.

Article  PubMed  PubMed Central  Google Scholar 

Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from professional antigen-presenting cells. Annu Rev Immunol. 2018;26(36):435–59.

Article  Google Scholar 

Rahimian N, Nahand JS, Hamblin MR, Mirzaei H. Exosomal MicroRNA profiling. Methods Mol Biol. 2023;2595:13–47.

Article  PubMed  Google Scholar 

Dong S, Wang Y, Liu Z, Zhang W, Yi K, Zhang X, et al. Beehive-inspired macroporous sers probe for cancer detection through capturing and analyzing exosomes in plasma. ACS Appl Mater Interfaces. 2020;12:5136–46.

Article  PubMed  Google Scholar 

Choi Y, Park U, Koo H-J, Park J-s, Lee DH, Kim K, et al. Exosome-mediated diagnosis of pancreatic cancer using lectin-conjugated nanoparticles bound to selective glycans. Biosens Bioelectron. 2021; 177: 112980;

Brinkman K, Meyer L, Bickel A, Enderle D, Berking C, Skog J, et al. Extracellular vesicles from plasma have higher tumour rna fraction than platelets. J Extracell Vesicles. 2020;9:1741176.

Article  PubMed  PubMed Central