Hals PA, Wang X, Xiao YF (2017) Effects of a purified krill oil phospholipid rich in long-chain omega-3 fatty acids on cardiovascular disease risk factors in non-human primates with naturally occurring diabetes type-2 and dyslipidemia. Lipids Health Dis 16:11. https://doi.org/10.1186/s12944-017-0411-z
Article CAS PubMed PubMed Central Google Scholar
Kim MG, Yang I, Lee HS, Lee JY, Kim K (2020) Lipid-modifying effects of krill oil vs fish oil: a network meta-analysis. Nutr Rev 78:699–708. https://doi.org/10.1093/nutrit/nuz102
Ulven SM, Holven KB (2015) Comparison of bioavailability of krill oil versus fish oil and health effect. Vasc Health Risk Manag 11:511–524. https://doi.org/10.2147/VHRM.S85165
Article PubMed PubMed Central Google Scholar
Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L (2014) Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 34:126–133. https://doi.org/10.1016/j.nutres.2013.12.003
Article CAS PubMed Google Scholar
Mozaffarian D, Maki KC, Bays HE, Aguilera F, Gould G, Hegele RA et al (2022) Effectiveness of a novel ω-3 krill oil agent in patients with severe hypertriglyceridemia: a randomized clinical trial. JAMA Netw Open 5(1):e2141898. https://doi.org/10.1001/jamanetworkopen.2021.41898
Article PubMed PubMed Central Google Scholar
Yang G, Lee J, Lee S et al (2016) Krill oil supplementation improves dyslipidemia and lowers body weight in mice fed a high-fat diet through activation of AMP-activated protein kinase. J Med Food 19(12):1120–1129. https://doi.org/10.1089/jmf.2016.3720
Article CAS PubMed Google Scholar
Zhu JJ, Shi JH, Qian WB, Cai ZZ, Li D (2008) Effects of krill oil on serum lipids of hyperlipidemic rats and human SW480 cells. Lipids Health Dis 7:30. https://doi.org/10.1186/1476-511X-7-30
Article CAS PubMed PubMed Central Google Scholar
Kim OK, Yun JM, Kim D, Park SJ, Lee C et al (2022) Krill oil inhibits cholesterol synthesis and stimulated cholesterol excretion in hypercholesterolemic rats. Mar Drugs 20(10):609. https://doi.org/10.3390/md20100609
Article CAS PubMed PubMed Central Google Scholar
Jayathilake AG, Kadife E, Kuol N, Luwor RB, Nurgali K, Su XQ (2022) Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice. BMC Complement Med Ther 22(1):34. https://doi.org/10.1186/s12906-022-03521-4
Article CAS PubMed PubMed Central Google Scholar
Jing W, Bi Y, Wang G, Zeng S, Han L, Yang H et al (2021) Krill oil perturbs proliferation and migration of mouse colon cancer cells in vitro by impeding extracellular signal-regulated protein kinase signaling pathway. Lipids 56(2):141–153. https://doi.org/10.1002/lipd.12281
Article CAS PubMed Google Scholar
Zhang H, Liu X, Li B, Zhang Y, Gao H, Zhao X et al (2023) Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice. Front Cell Dev Biol 11:1180483. https://doi.org/10.3389/fcell.2023.1180483
Article PubMed PubMed Central Google Scholar
Choi JY, Jang JS, Son DJ, Im HS, Kim JY, Park JE et al (2017) (2017) Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment. Int J Mol Sci 18(12):2554. https://doi.org/10.3390/ijms18122554
Article CAS PubMed PubMed Central Google Scholar
Tian A, Sun L, Zheng Y, Du L, Huang X, Wu H (2024) Krill oil attenuates diabetes-associated cognitive dysfunction by inhibiting microglial polarization-induced neuron injury. J Funct Foods 114:106064. https://doi.org/10.1016/j.jff.2024.106064
Panchal D, Pandya T, Kevlani V, Shah S, Acharya S (2023) Development and evaluation of novel krill oil-based clomiphene microemulsion as a therapeutic strategy for PCOS treatment. Drug Deliv Transl Res 13(9):2254–2271. https://doi.org/10.1007/s13346-023-01304-z
Article CAS PubMed Google Scholar
Seto Y, Morizane C, Ueno K, Sato H, Onoue S (2018) Supersaturable self-emulsifying drug delivery system of krill oil with improved oral absorption and hypotriglyceridemic function. J Agric Food Chem 66(21):5352–5358. https://doi.org/10.1021/acs.jafc.8b00693
Article CAS PubMed Google Scholar
Kermasha S, Aziz S, Gill J, Neufeld R (2018) Microencapsulation of esterified krill oil, using complex coacervation. J Microencapsul 35(1):36–48. https://doi.org/10.1080/02652048.2017.1413148
Article CAS PubMed Google Scholar
Kim JH, Hong SS, Lee M, Lee EH, Rhee I, Chang SY (2019) Krill oil-incorporated liposomes as an effective nanovehicle to ameliorate the inflammatory responses of dss-induced colitis. Int J Nanomed 14:8305–8320. https://doi.org/10.2147/IJN.S220053
Liu Y, Fu D, Bi A, Wang S, Li X, Xu X et al (2021) Development of a high internal phase emulsion of antarctic krill oil diluted by soybean oil using casein as a co-emulsifier. Foods 10(5):917. https://doi.org/10.3390/foods10050917
Article CAS PubMed PubMed Central Google Scholar
Zhao J, Jiang K, Chen Y, Chen J, Zheng Y, Yu H et al (2020) Preparation and characterization of microemulsions based on antarctic krill oil. Mar Drugs 18(10):492. https://doi.org/10.3390/md18100492
Article CAS PubMed PubMed Central Google Scholar
Zhu JJ, Zhuang P, Luan L, Sun Q, Cao F (2015) Preparation and characterization of novel nanocarriers containing krill oil for food application. J Funct Foods Part B. 19:902–912. https://doi.org/10.1016/j.jff.2015.06.017
Fu DW, Li JJ, Dai DM, Zhou DY, Zhu BW, Song L (2023) Development and characterization of self-emulsifying high internal phase emulsions using endogenous phospholipids from antarctic krill oil. Food Chem 428:136765. https://doi.org/10.1016/j.foodchem.2023.136765
Article CAS PubMed Google Scholar
Sultana A, Maki Y, Fermin A, Adachi S, Yoshii H (2021) Stability of eicosapentaenoic acid and docosahexaenoic acid in spray-dried powder of emulsified krill oil. Future Foods 3:100009. https://doi.org/10.1016/j.fufo.2020.100009
Zeng X, Yin F, Zhao G, Guo C, Li D, Liu H (2024) Mechanism of color change in Antarctic krill oil during storage. Food Chem 444:138583. https://doi.org/10.1016/j.foodchem.2024.138583
Article CAS PubMed Google Scholar
Kumar A, Jindal A, Singh APK (2023) Cytotoxicity and bioavailability assessment from thiamin-phospholipid complexation loaded ajwain oil based self-nanoemulsifying system. J Dis Sci Tech. https://doi.org/10.1080/01932691.2023.2266010
Bansal T, Mustafa G, Khan ZI, Ahmad FJ, Khar RK, Talegaonkar S (2008) Solid self-nanoemulsifying delivery systems as a platform technology for formulation of poorly soluble drugs. Crit Rev Ther Drug Carrier Syst 25(1):63–116. https://doi.org/10.1615/critrevtherdrugcarriersyst.v25.i1.20
Article CAS PubMed Google Scholar
Kumar A, Kumari S, Kumar S (2024) Raspberry ketone loaded self nanoemulsifying system of cardamom oil: assessment of phase behaviour, dissolution rate and anti-hyperlipidemic activity. J Drug Delivery Science & Tech 99:105937. https://doi.org/10.1016/j.jddst.2024.105937
Cicero F, Zhou D, Liu Y, Zhao Q, Liu Z, Song L (2018) Extraction and characterization of phospholipid-enriched oils from antarctic krill (euphausia superba) with different solvents. J Aq Food Product Tech 27:292–304. https://doi.org/10.1080/10498850.2018.1428706
Annisa R, Yuwono M, Hendradi E (2021) Formulation and characterization of Eleutherine palmifolia extract-loaded self-nanoemulsifying drug delivery system (SNEDDS). J Basic Clin Physiol Pharmacol 32(4):859–865.
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