We are grateful to the following for their support of the trial conduct and delivery:

Trial Management: Keele University Clinical Trials Unit – especially Nancy Fernandes Da Silva, Vicki Harper, Andrea Cherrington, Sarah Bathers and Louise Phillips-Darby. Patient Advisory Group:

David Coyle (chair), Liam Howorth, Cassie Brzoza, Pauline Obi, Michael Winfrow.

Trial Steering Committee:

Richard Fluck (chair), James Wason, Elaine Davies, James Mason, Katherine Crompton, Nicola Heron, Melina Dritsaki, Brett Dowds, Liz Pryde. Independent Data Monitoring Committee: Richard Haynes (chair), Simon Bond, Russell Roberts.

Participating Sites (Principal Investigators):

Julie Wessels, University Hospitals of North Midlands, Stoke-on-Trent, UK.

Arfi Khwaja, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Indranil Dasgupta, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Andrew Davenport, Royal Free Hampstead NHS Trust, London, UK.

Enric Vilar, East and North Hertfordshire NHS Trust, Stevenage, UK.

Sandip Mitra, Manchester University NHS Foundation Trust, Manchester, UK.

Albert Power, North Bristol NHS Trust, Bristol, UK.

David Meredith, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

Michael Schulz, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool, UK.

Michael Bedford, East Kent Hospitals University NHS Trust, Canterbury, UK.

Kieran McCafferty, Barts Health NHS Trust, London, UK.

Punit Yadav, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Sally Pugh, Gloucestershire Hospital NHS Foundation Trust, Gloucester, UK.

Stewart Lambie, NHS Highland, Raigmore, Scotland, UK.

Beng So, Lancashire Teaching Hospitals, Preston, UK.

James Burton, University Hospitals of Leicester NHS Trust, Leicester, UK.

Janet Hegarty, Salford Royal NHS Foundation Trust, Salford, UK.

Timothy Shipley, South Tees NHS Trust, Middlesbrough, UK.

Neal Morgan, Southern Health and Social Care Trust, Newry, Northern Ireland, UK

Linda Bisset, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Thomas Connor, Oxford University Hospital NHS Trust, Oxford, UK.

James Chess, Abertawe Bro Morgannwg University Health Board, Swansea, Wales, UK.

Colin Jones, York Teaching Hospital NHS Foundation Trust, York, UK.

Azra Nache, Aintree University Hospital NHS Foundation Trust, Aintree, UK.

Rajan Patel, NHS Greater Glasgow and Clyde, Glasgow, Scotland, UK.

Neill Duncan, Imperial College Healthcare NHS Trust, London, UK.

Johann Nicholas, Shrewsbury and Telford Hospital NHS Trust, Shrewsbury, UK.

Sharlene Greenwood, King’s College Hospital NHS Foundation Trust, London, UK.

Kanwaljit Sandhu, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.

Subash Somolanka, Epsom and St Helier University Hospitals NHS Trust, UK.

Kate Shiell, NHS Fife, Kirkaldy, Scotland, UK.

Stephanie Bolton, Northern Health and Social Care Trust, Antrim, Northern Ireland, UK.

Abdulfattah Alejmi, Betsi Cadwalader University Health Board, Bangor, Wales, UK.