Colao A, Grasso LFS, Giustina A et al (2019) Acromegaly. Nat Rev Dis Primers 5:20. https://doi.org/10.1038/s41572-019-0071-6

Article  PubMed  Google Scholar 

Claessen KMJA, Mazziotti G, Biermasz NR, Giustina A (2016) Bone and joint disorders in acromegaly. Neuroendocrinology 103:86–95. https://doi.org/10.1159/000375450

Article  CAS  PubMed  Google Scholar 

Bonadonna S, Mazziotti G, Nuzzo M et al (2005) Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women. J Bone Miner Res 20:1837–1844. https://doi.org/10.1359/JBMR.050603

Article  PubMed  Google Scholar 

Mazziotti G, Bianchi A, Bonadonna S et al (2008) Prevalence of vertebral fractures in men with acromegaly. J Clin Endocrinol Metab 93:4649–4655. https://doi.org/10.1210/jc.2008-0791

Article  CAS  PubMed  Google Scholar 

Padova G, Borzì G, Incorvaia L et al (2011) Prevalence of osteoporosis and vertebral fractures in acromegalic patients. Clin Cases Miner Bone Metab 8:37–43

PubMed  PubMed Central  Google Scholar 

Wassenaar MJE, Biermasz NR, Hamdy NAT et al (2011) High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly. Eur J Endocrinol 164:475–483. https://doi.org/10.1530/EJE-10-1005

Article  CAS  PubMed  Google Scholar 

Genant HK, Jergas M, Palermo L et al (1996) Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis. J Bone Miner Res 11:984–996. https://doi.org/10.1002/jbmr.5650110716

Article  CAS  PubMed  Google Scholar 

Samelson EJ, Hannan MT, Zhang Y, Genant HK, Felson DT, Kiel DP (2006) Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study. J Bone Miner Res 21:1207–1214. https://doi.org/10.1359/jbmr.060513

Article  PubMed  Google Scholar 

Bima C, Chiloiro S, Mormando M et al (2016) Understanding the effect of acromegaly on the human skeleton. Expert Rev Endocrinol Metab 11:263–270. https://doi.org/10.1080/17446651.2016.1179108

Article  CAS  PubMed  Google Scholar 

Mazziotti G, Bianchi A, Porcelli T et al (2013) Vertebral fractures in patients with acromegaly: a 3-year prospective study. J Clin Endocrinol Metab 98:3402–3410. https://doi.org/10.1210/jc.2013-1460

Article  CAS  PubMed  Google Scholar 

Mormando M, Nasto LA, Bianchi A et al (2014) GH receptor isoforms and skeletal fragility in acromegaly. Eur J Endocrinol 171:237–245. https://doi.org/10.1530/EJE-14-0205

Article  CAS  PubMed  Google Scholar 

Laurent M, Sinnesael M, Vanderschueren D et al (2014) Androgens and estrogens in skeletal sexual dimorphism. Asian J Androl 16:213. https://doi.org/10.4103/1008-682X.122356

Article  CAS  PubMed  PubMed Central  Google Scholar 

Golds G, Houdek D, Arnason T (2017) Male hypogonadism and osteoporosis: the effects, clinical consequences, and treatment of testosterone deficiency in bone health. Int J Endocrinol 2017:1–15. https://doi.org/10.1155/2017/4602129

Article  CAS  Google Scholar 

Piskinpasa ME, Piskinpasa H (2020) Bone biochemical markers in acromegaly: an association with disease activity and gonadal status. North Clin Istanb 9:74–81. https://doi.org/10.14744/nci.2020.35467

Article  Google Scholar 

Biermasz NR, Hamdy NAT, Pereira AM, Romijn JA, Roelfsema F (2005) Long-term maintenance of the anabolic effects of GH on the skeleton in successfully treated patients with acromegaly. Eur J Endocrinol 152:53–60. https://doi.org/10.1530/eje.1.01820

Article  CAS  PubMed  Google Scholar 

Bolanowski M, Daroszewski J, Mędraś M, Zadrożna-Śliwka B (2005) Bone mineral density and turnover in patients with acromegaly in relation to sex, disease activity, and gonadal function. J Bone Miner Metab 24:72–78. https://doi.org/10.1007/s00774-005-0649-9

Article  Google Scholar 

Zgliczynski W, Kochman M, Misiorowski W, Zdunowski P (2007) In acromegaly, increased bone mineral density (BMD) is determined by GH-excess, gonadal function and gender. Neuro Endocrinol Lett 28:621–628

CAS  PubMed  Google Scholar 

Katznelson L, Laws ER, Melmed S et al (2014) Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 99:3933–3951. https://doi.org/10.1210/jc.2014-2700

Article  CAS  PubMed  Google Scholar 

Constantin T, Tangpricha V, Shah R et al (2017) Calcium and bone turnover markers in acromegaly: a prospective, controlled study. J Clin Endocrinol Metab 102:2416–2424. https://doi.org/10.1210/jc.2016-3693

Article  PubMed  Google Scholar 

Halse J, Haugen HN (1980) Calcium and phosphate metabolism in acromegaly. Acta Endocrinol (Copenh) 94:459–467. https://doi.org/10.1530/acta.0.0940459

Article  CAS  PubMed  Google Scholar 

Xie T, Tian P, Wu S et al (2020) Serum phosphate: does it more closely reflect the true state of acromegaly? J Clin Neurosci 71:26–31. https://doi.org/10.1016/j.jocn.2019.11.012

Article  CAS  PubMed  Google Scholar 

Fredstorp L, Pernow Y, Werner S (1993) The short and long-term effects of octreotide on calcium homeostasis in patients with acromegaly. Clin Endocrinol (Oxf) 39:331–336. https://doi.org/10.1111/j.1365-2265.1993.tb02373.x

Article  CAS  PubMed  Google Scholar 

Štĕpán J, Marek J, Havránek T, Doležal V, Pacovský V (1979) Bone isoenzyme of serum alkaline phosphatase in acromegaly. Clin Chim Acta 93:355–363. https://doi.org/10.1016/0009-8981(79)90285-7

Article  PubMed  Google Scholar 

de la Piedra C, Carbó E, Larrañaga J et al (1988) Correlation among plasma osteocalcin, growth hormone, and somatomedin C in acromegaly. Calcif Tissue Int 43:44–45. https://doi.org/10.1007/BF02555167

Article  PubMed  Google Scholar 

Marazuela M, Astigarraga B, Tabuenca MJ, Estrada J, Marín F, Lucas T (1993) Serum bone Gla protein as a marker of bone turnover in acromegaly. Calcif Tissue Int 52:419–421. https://doi.org/10.1007/BF00571329

Article  CAS  PubMed  Google Scholar 

Scillitani A, Chiodini I, Carnevale V et al (1997) Skeletal involvement in female acromegalic subjects: the effects of growth hormone excess in amenorrheal and menstruating patients. J Bone Miner Res 12:1729–1736. https://doi.org/10.1359/jbmr.1997.12.10.1729

Article  CAS  PubMed  Google Scholar 

Sucunza N, Barahona MJ, Resmini E et al (2009) A link between bone mineral density and serum adiponectin and visfatin levels in acromegaly. J Clin Endocrinol Metab 94:3889–3896. https://doi.org/10.1210/jc.2009-0474

Article  CAS  PubMed  Google Scholar 

Gevers EF, Loveridge N, Robinson ICAF (2002) Bone marrow adipocytes: a neglected target tissue for growth hormone. Endocrinology 143:4065–4073. https://doi.org/10.1210/en.2002-220428

Article  CAS  PubMed  Google Scholar 

Abdallah BM, Ding M, Jensen CH et al (2007) Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology 148:3111–3121. https://doi.org/10.1210/en.2007-0171

Article  CAS  PubMed  Google Scholar 

Hubina E, Lakatos P, Kovács L et al (2003) Effects of 24 months of growth hormone (GH) treatment on serum carboxylated and undercarboxylated osteocalcin levels in GH-deficient adults. Calcif Tissue Int 74:55–59. https://doi.org/10.1007/s00223-002-2149-4

Article  CAS  PubMed