Pre-emptive therapeutic decisions based on measurable residual disease status in acute myeloid leukemia: ready for prime time?

Heuser M, Freeman SD, Ossenkoppele GJ, Buccisano F, Hourigan CS, Ngai LL, et al. 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party. Blood. 2021;138:2753–67.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Short NJ, Zhou S, Fu C, Berry DA, Walter RB, Freeman SD, et al. Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis. JAMA Oncol. 2020;6:1890–9.

Zhang H, Zheng X, Guo W, Xia Y, Zhang R, Zhai W, et al. Outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: validation, comparison and improvement of 2022 ELN genetic risk system. Exp Hematol Oncol. 2024;13:16.

Article  PubMed  PubMed Central  Google Scholar 

Tiong IS, Hiwase DK, Abro E, Bajel A, Palfreyman E, Beligaswatte A, et al. Targeting Molecular Measurable Residual Disease and Low-Blast Relapse in AML With Venetoclax and Low-Dose Cytarabine: A Prospective Phase II Study (VALDAC). J Clin Oncol. 2024;42:2161–73.

Article  PubMed  CAS  Google Scholar 

Gorello P, Cazzaniga G, Alberti F, Dell’Oro MG, Gottardi E, Specchia G, et al. Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations. Leukemia. 2006;20:1103–8.

Article  PubMed  CAS  Google Scholar 

Liso A, Bogliolo A, Freschi V, Martelli MP, Pileri SA, Santodirocco M, et al. In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML. Leukemia. 2008;22:1285–9.

Article  PubMed  CAS  Google Scholar 

Hasserjian RP, Steensma DP, Graubert TA, Ebert BL. Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia. Blood. 2020;135:1729–38.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Balsat M, Renneville A, Thomas X, de Botton S, Caillot D, Marceau A, et al. Postinduction Minimal Residual Disease Predicts Outcome and Benefit From Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia With NPM1 Mutation: A Study by the Acute Leukemia French Association Group. J Clin Oncol. 2017;35:185–93.

Article  PubMed  CAS  Google Scholar 

Ivey A, Hills RK, Simpson MA, Jovanovic JV, Gilkes A, Grech A, et al. Assessment of Minimal Residual Disease in Standard-Risk AML. N Engl J Med. 2016;374:422–33.

Article  PubMed  CAS  Google Scholar 

Krönke J, Schlenk RF, Jensen KO, Tschürtz F, Corbacioglu A, Gaidzik VI, et al. Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol. 2011;29:2709–16.

Article  PubMed  Google Scholar 

Shayegi N, Kramer M, Bornhäuser M, Schaich M, Schetelig J, Platzbecker U, et al. The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML. Blood. 2013;122:83–92.

Article  PubMed  CAS  Google Scholar 

Tiong IS, Dillon R, Ivey A, Kuzich JA, Thiagarajah N, Sharplin KM, et al. Clinical impact of NPM1-mutant molecular persistence after chemotherapy for acute myeloid leukemia. Blood Adv. 2021;5:5107–11.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Höllein A, Meggendorfer M, Dicker F, Jeromin S, Nadarajah N, Kern W, et al. Mutated AML can relapse with wild-type NPM1: persistent clonal hematopoiesis can drive relapse. Blood Adv. 2018;2:3118–25.

Article  PubMed  PubMed Central  Google Scholar 

Cocciardi S, Dolnik A, Kapp-Schwoerer S, Rücker FG, Lux S, Blätte TJ, et al. Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation. Nat Commun. 2019;10:2031.

Article  PubMed  PubMed Central  Google Scholar 

Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, et al. Diagnosis and Management of AML in Adults: 2022 ELN Recommendations from an International Expert Panel. Blood. 2022;140:1345–77.

Dillon R, Hills R, Freeman S, Potter N, Jovanovic J, Ivey A, et al. Molecular MRD status and outcome after transplantation in NPM1-mutated AML. Blood. 2020;135:680–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kayser S, Benner A, Thiede C, Martens U, Huber J, Stadtherr P, et al. Pretransplant NPM1 MRD levels predict outcome after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia. Blood Cancer J. 2016;6:e449.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Othman J, Potter N, Ivey A, Tazi Y, Papaemmanuil E, Jovanovic J, et al. Molecular, clinical, and therapeutic determinants of outcome in NPM1-mutated AML. Blood. 2024;144:714–28.

Article  PubMed  CAS  Google Scholar 

Hourigan CS, Dillon LW, Gui G, Logan BR, Fei M, Ghannam J, et al. Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual Disease. J Clin Oncol. 2020;38:1273–83.

Article  PubMed  CAS  Google Scholar 

Othman J, Potter N, Ivey A, Jovanovic J, Runglall M, Freeman SD, et al. Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission. Blood. 2024;143:1931–6.

Article  PubMed  CAS  Google Scholar 

Platzbecker U, Middeke JM, Sockel K, Herbst R, Wolf D, Baldus CD, et al. Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial. Lancet Oncol. 2018;19:1668–79.

Article  PubMed  CAS  Google Scholar 

Tiong IS, Dillon R, Ivey A, Teh TC, Nguyen P, Cummings N, et al. Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low-intensity chemotherapy in acute myeloid leukaemia. Br J Haematol. 2021;192:1026–30.

Article  PubMed  CAS  Google Scholar 

Jimenez-Chillon C, Othman J, Taussig D, Jimenez-Vicente C, Martinez-Roca A, Tiong IS, et al. Venetoclax-based low intensity therapy in molecular failure of NPM1-mutated AML. Blood Adv. 2024;8:343–52.

Article  PubMed  CAS  Google Scholar 

Sartor C, Brunetti L, Audisio E, Cignetti A, Zannoni L, Cristiano G, et al. A venetoclax and azacitidine bridge-to-transplant strategy for NPM1-mutated acute myeloid leukaemia in molecular failure. Br J Haematol. 2023;202:599–607.

Article  PubMed  CAS  Google Scholar 

Othman J, Tiong IS, O’Nions J, Dennis M, Mokretar K, Ivey A, et al. Molecular MRD is strongly prognostic in patients with NPM1-mutated AML receiving venetoclax-based nonintensive therapy. Blood. 2024;143:336–41.

Article  PubMed  CAS  Google Scholar 

Bug G, Schafer-Eckart K, Rave C, Baldauf H, et al. Excellent Outcome of Patients Proceeding to Allogeneic Hematopoietic Cell Transplantation with Untreated Molecular Relapse of NPM1-Mutated AML. EBMT. 2024.

Orvain C, Bertoli S, Peterlin P, Desbrosses Y, Dumas PY, Iat A, et al. Molecular relapse after first-line intensive therapy in patients with CBF or NPM1-mutated acute myeloid leukemia - a FILO study. Leukemia. 2024;38:1949–57.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chua CC, Hammond D, Kent A, Tiong IS, Konopleva MY, Pollyea DA, et al. Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia. Blood Adv. 2022;6:3879–83.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pratz KW, Jonas BA, Pullarkat V, Recher C, Schuh AC, Thirman MJ, et al. Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine. J Clin Oncol. 2022;40:855–65.

Article  PubMed  CAS  Google Scholar 

Dillon LW, Gui G, Page KM, Ravindra N, Wong ZC, Andrew G, et al. DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant. JAMA. 2023;329:745–55.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cappelli LV, Meggendorfer M, Baer C, Nadarajah N, Hutter S, Jeromin S, et al. Indeterminate and oncogenic potential: CHIP vs CHOP mutations in AML with NPM1 alteration. Leukemia. 2022;36:394–402.

Article  PubMed  CAS 

留言 (0)

沒有登入
gif