Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia

Girardi T, Vicente C, Cools J, De Keersmaecker K. The genetics and molecular biology of T-ALL. Blood. 2017;129:1113–23.

Article  CAS  PubMed  Google Scholar 

Pui CH, Carroll WL, Meshinchi S, Arceci RJ. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol. 2011;29:551–65.

Article  PubMed  Google Scholar 

van der Zwet CordoV, Canté-Barrett JCG, Pieters K, Meijerink R. JPP. T-cell acute lymphoblastic leukemia: a roadmap to targeted therapies. Blood Cancer Discov. 2021;2:19–31.

Article  PubMed  Google Scholar 

Patel AA, Thomas J, Rojek AE, Stock W. Biology and treatment paradigms in T Cell acute lymphoblastic leukemia in older adolescents and adults. Curr Treat Options Oncol. 2020;21:57.

Article  PubMed  Google Scholar 

Pui C-H, Evans William E. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354:166–78.

Article  CAS  PubMed  Google Scholar 

Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, et al. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet. 2017;49:1211–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, et al. Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nat Genet. 2017;49:1274–81.

Article  CAS  PubMed  Google Scholar 

Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, et al. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 2012;22:209–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Amanda S, Wang C, King Tan T, Zulfaqar Ali M, Zhong Leong W, et al. Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia. Haematologica. 2021;106:1545–58.

Article  CAS  PubMed  Google Scholar 

Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, et al. ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Genes Dev. 2017;31:2343–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weng, Ferrando AP, Lee AA, Morris W, JPt, Silverman LB, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269–71.

Article  CAS  PubMed  Google Scholar 

Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Belver L, Wendorff AA, et al. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014;20:1130–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ong JZL, Tan TK, Wang L, Tan SH, Sanda T. Regulatory mechanisms and context-dependent roles of TAL1 in T-cell acute lymphoblastic leukemia. Haematologica. 2023;109:1359–72.

O’Rourke JP, Ness SA. Alternative RNA splicing produces multiple forms of c-Myb with unique transcriptional activities. Mol Cell Biol. 2008;28:2091–101.

Article  PubMed  PubMed Central  Google Scholar 

Nakano K, Uchimaru K, Utsunomiya A, Yamaguchi K, Watanabe T. Dysregulation of c-Myb pathway by aberrant expression of proto-oncogene MYB provides the basis for malignancy in adult T-cell leukemia/lymphoma cells. Clin Cancer Res. 2016;22:5915–28.

Article  CAS  PubMed  Google Scholar 

Frerich CA, Sedam HN, Kang H, Mitani Y, El-Naggar AK, Ness SA. N-terminal truncated Myb with new transcriptional activity produced through use of an alternative MYB promoter in salivary gland adenoid cystic carcinoma. Cancers. 2019;12:45.

Article  PubMed  PubMed Central  Google Scholar 

Duprey SP, Boettiger D. Developmental regulation of c-myb in normal myeloid progenitor cells. Proc Natl Acad Sci USA. 1985;82:6937–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Craig RW, Bloch A. Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1984;44:442–6.

CAS  PubMed  Google Scholar 

Sandberg ML, Sutton SE, Pletcher MT, Wiltshire T, Tarantino LM, Hogenesch JB, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153–66.

Article  CAS  PubMed  Google Scholar 

Sicurella C, Freeman R, Micallef S, Mucenski ML, Bertoncello I, Ramsay RG. Defective stem cell factor expression in c-myb null fetal liver stroma. Blood Cells Mol Dis. 2001;27:470–8.

Article  CAS  PubMed  Google Scholar 

Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, et al. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 1991;65:677–89.

Article  CAS  PubMed  Google Scholar 

Rosson D, O’Brien TG. Constitutive c-myb expression in K562 cells inhibits induced erythroid differentiation but not tetradecanoyl phorbol acetate-induced megakaryocytic differentiation. Mol Cell Biol. 1995;15:772–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yanagisawa H, Nagasawa T, Kuramochi S, Abe T, Ikawa Y, Todokoro K. Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation. Biochim Biophys Acta. 1991;1088:380–4.

Article  CAS  PubMed  Google Scholar 

Zhao L, Ye P, Gonda TJ. The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1. Oncogene. 2014;33:4442–9.

Article  CAS  PubMed  Google Scholar 

Sakamoto H, Dai G, Tsujino K, Hashimoto K, Huang X, Fujimoto T, et al. Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development. Blood. 2006;108:896–903.

Article  CAS  PubMed  Google Scholar 

O’Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, et al. Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med. 2007;204:3059–66.

Article  PubMed  PubMed Central  Google Scholar 

Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA, et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood. 2007;110:1251–61.

Article  CAS  PubMed  Google Scholar 

Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat Genet. 2007;39:593.

Article  CAS  PubMed  Google Scholar 

Bardelli V, Arniani S, Pierini V, Pierini T, Di Giacomo D, Gorello P, et al. MYB rearrangements and over-expression in T-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2021;60:482–88.

Article  CAS  PubMed  Google Scholar 

Correia NC, Durinck K, Leite AP, Ongenaert M, Rondou P, Speleman F, et al. Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia. Leukemia. 2013;27:1603–6.

Article  CAS  PubMed  Google Scholar 

Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, et al. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 2013;210:1545–57.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif