MSI2 mediates WNT/β-Catenin pathway function in hematopoietic stem cells

Will B, Zhou L, Vogler TO, Ben-Neriah S, Schinke C, Tamari R, et al. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood. 2012;120:2076–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ebert BL. Molecular dissection of the 5q deletion in myelodysplastic syndrome. Semin Oncol. 2011;38:621–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stoddart A, Wang J, Hu C, Fernald AA, Davis EM, Cheng JX, et al. Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apc(del/+) MDS mouse model. Blood. 2017;129:2959–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kharas MG, Lengner CJ. Stem Cells, Cancer, and MUSASHI in Blood and Guts. Trends Cancer. 2017;3:347–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pellagatti A, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, et al. Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells. Leukemia. 2010;24:756–64.

Article  CAS  PubMed  Google Scholar 

Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med. 2010;16:903–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheng Y, Ma R, Yu C, Wu Q, Zhang S, Paulsen K, et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood. 2021;137:610–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moparthi L, Koch S. FOX transcription factors are common regulators of Wnt/β-catenin-dependent gene transcription. J Biol Chem. 2023;299:104667.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asl ER, Amini M, Najafi S, Mansoori B, Mokhtarzadeh A, Mohammadi A, et al. Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression. Life Sci. 2021;278:119499.

Article  CAS  PubMed  Google Scholar 

Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, et al. Methylation of dual-specificity phosphatase 4 controls cell differentiation. Cell Rep. 2021;36:109421.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Figg JW, Barajas JM, Obeng EA. Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia. Curr Opin Hematol. 2021;28:73–79.

Article  CAS  PubMed  Google Scholar 

Nguyen DTT, Lu Y, Chu KL, Yang X, Park SM, Choo ZN, et al. HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells. Nat Commun. 2020;11:2026.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gíslason MH, Demircan GS, Prachar M, Furtwängler B, Schwaller J, Schoof EM, et al. BloodSpot 3.0: a database of gene and protein expression data in normal and malignant haematopoiesis. Nucleic Acids Res. 2024;52:D1138–d1142.

Article  PubMed  Google Scholar 

Sherbet GV. Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy. Cancer Lett. 2009;280:15–30.

Article  CAS  PubMed  Google Scholar 

Li Y, Li PK, Roberts MJ, Arend RC, Samant RS, Buchsbaum DJ. Multi-targeted therapy of cancer by niclosamide: A new application for an old drug. Cancer Lett. 2014;349:8–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sack U, Walther W, Scudiero D, Selby M, Kobelt D, Lemm M, et al. Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. J Natl Cancer Inst. 2011;103:1018–36.

Article  CAS  PubMed  Google Scholar 

Watts J, Lin TL, Mims A, Patel P, Lee C, Shahidzadeh A, et al. Post-hoc Analysis of Pharmacodynamics and Single-Agent Activity of CD3xCD123 Bispecific Antibody APVO436 in Relapsed/Refractory AML and MDS Resistant to HMA or Venetoclax Plus HMA. Front Oncol. 2021;11:806243.

Article  CAS  PubMed  Google Scholar 

Mishra SK, Siddique HR, Saleem M. S100A4 calcium-binding protein is key player in tumor progression and metastasis: preclinical and clinical evidence. Cancer Metastasis Rev. 2012;31:163–72.

Article  CAS  PubMed  Google Scholar 

Alanazi B, Munje CR, Rastogi N, Williamson AJK, Taylor S, Hole PS, et al. Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia. Leukemia. 2020;34:427–40.

Article  CAS  PubMed  Google Scholar 

Milani M, Mammarella E, Rossi S, Miele C, Lattante S, Sabatelli M, et al. Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis. J Neuroinflammation. 2021;18:132.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen J, Jiao B, Tran M, Wang Y. Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis. Cells. 2022;11:2762.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Treese C, Hartl K, Pötzsch M, Dahlmann M, von Winterfeld M, Berg E, et al. S100A4 Is a Strong Negative Prognostic Marker and Potential Therapeutic Target in Adenocarcinoma of the Stomach and Esophagus. Cells. 2022;11:1056.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Serrano A, Apolloni S, Rossi S, Lattante S, Sabatelli M, Peric M, et al. The S100A4 Transcriptional Inhibitor Niclosamide Reduces Pro-Inflammatory and Migratory Phenotypes of Microglia: Implications for Amyotrophic Lateral Sclerosis. Cells. 2019;8:1261.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang W, Liu LB, Liu FL, Wu YH, Zhen ZD, Fan DY, et al. Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation. Nat Commun. 2023;14:2476.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leung SW, Chou CJ, Huang TC, Yang PM. An Integrated Bioinformatics Analysis Repurposes an Antihelminthic Drug Niclosamide for Treating HMGA2-Overexpressing Human Colorectal Cancer. Cancers. 2019;11:1482.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Helfman DM. Niclosamide: an established antihelminthic drug as a potential therapy against S100A4-mediated metastatic colon tumors. J Natl Cancer Inst. 2011;103:991–2.

Article  CAS  PubMed  Google Scholar 

Burock S, Daum S, Keilholz U, Neumann K, Walther W, Stein U. Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial. BMC Cancer. 2018;18:297.

Article  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif