Crosby, D. et al. Early detection of cancer. Science 375, eaay9040 (2022).
Article CAS PubMed Google Scholar
Jamieson, C. H. M. & Weissman, I. L. Stem-cell aging and pathways to precancer evolution. N. Engl. J. Med. 389, 1310–1319 (2023).
Article CAS PubMed Google Scholar
Jassim, A., Rahrmann, E. P., Simons, B. D. & Gilbertson, R. J. Cancers make their own luck: theories of cancer origins. Nat. Rev. Cancer 23, 710–724 (2023).
Article CAS PubMed Google Scholar
Greaves, M. & Maley, C. C. Clonal evolution in cancer. Nature 481, 306–313 (2012).
Article CAS PubMed PubMed Central Google Scholar
Kakiuchi, N. & Ogawa, S. Clonal expansion in non-cancer tissues. Nat. Rev. Cancer 21, 239–256 (2021).
Article CAS PubMed Google Scholar
Li, R. et al. A body map of somatic mutagenesis in morphologically normal human tissues. Nature 597, 398–403 (2021).
Article CAS PubMed Google Scholar
Kuipers, E. J. et al. Colorectal cancer. Nat. Rev. Dis. Primers 1, 15065 (2015).
Article PubMed PubMed Central Google Scholar
Herbst, R. S., Heymach, J. V. & Lippman, S. M. Lung cancer. N. Engl. J. Med. 359, 1367–1380 (2008).
Article CAS PubMed PubMed Central Google Scholar
Yuan, S., Almagro, J. & Fuchs, E. Beyond genetics: driving cancer with the tumour microenvironment behind the wheel. Nat. Rev. Cancer 24, 274–286 (2024).
Article CAS PubMed PubMed Central Google Scholar
Pashayan, N. & Pharoah, P. D. P. The challenge of early detection in cancer. Science 368, 589–590 (2020).
Article CAS PubMed Google Scholar
Le Magnen, C., Dutta, A. & Abate-Shen, C. Optimizing mouse models for precision cancer prevention. Nat. Rev. Cancer 16, 187–196 (2016).
Article PubMed PubMed Central Google Scholar
Srivastava, S. et al. The making of a precancer atlas: promises, challenges, and opportunities. Trends Cancer 4, 523–536 (2018).
Gengenbacher, N., Singhal, M. & Augustin, H. G. Preclinical mouse solid tumour models: status quo, challenges and perspectives. Nat. Rev. Cancer 17, 751–765 (2017).
Article CAS PubMed Google Scholar
Chen, X. X. et al. Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing. Nat. Commun. 8, 524 (2017).
Article CAS PubMed PubMed Central Google Scholar
Chitsazzadeh, V. et al. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates. Nat. Commun. 7, 12601 (2016).
Article CAS PubMed PubMed Central Google Scholar
Wils, L. J. et al. Elucidating the genetic landscape of oral leukoplakia to predict malignant transformation. Clin. Cancer Res. 29, 602–613 (2023).
Article CAS PubMed Google Scholar
Ganz, J. et al. Rates and patterns of clonal oncogenic mutations in the normal human brain. Cancer Discov. 12, 172–185 (2022).
Article CAS PubMed Google Scholar
Moore, L. et al. The mutational landscape of normal human endometrial epithelium. Nature 580, 640–646 (2020).
Article CAS PubMed Google Scholar
Lawson, A. R. J. et al. Extensive heterogeneity in somatic mutation and selection in the human bladder. Science 370, 75–82 (2020).
Article CAS PubMed Google Scholar
Yokoyama, A. et al. Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature 565, 312–317 (2019).
Article CAS PubMed Google Scholar
Lee-Six, H. et al. The landscape of somatic mutation in normal colorectal epithelial cells. Nature 574, 532–537 (2019).
Article CAS PubMed Google Scholar
Brunner, S. F. et al. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature 574, 538–542 (2019).
Article CAS PubMed PubMed Central Google Scholar
Suda, K. et al. Clonal expansion and diversification of cancer-associated mutations in endometriosis and normal endometrium. Cell Rep. 24, 1777–1789 (2018).
Article CAS PubMed Google Scholar
Martincorena, I. et al. Somatic mutant clones colonize the human esophagus with age. Science 362, 911–917 (2018).
Article CAS PubMed PubMed Central Google Scholar
Martincorena, I. et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348, 880–886 (2015).
Article CAS PubMed PubMed Central Google Scholar
Li, R. et al. Macroscopic somatic clonal expansion in morphologically normal human urothelium. Science 370, 82–89 (2020).
Article CAS PubMed Google Scholar
Robles, A. I., Jen, J. & Harris, C. C. Clinical outcomes of TP53 mutations in cancers. Cold Spring Harb. Perspect. Med. 6, a026294 (2016).
Article PubMed PubMed Central Google Scholar
Ren, X. et al. Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma. Nat. Commun. 13, 6300 (2022).
Article CAS PubMed PubMed Central Google Scholar
Liao, G. et al. Single-cell transcriptomics provides insights into the origin and microenvironment of human oesophageal high-grade intraepithelial neoplasia. Clin. Transl. Med. 12, e874 (2022).
Article CAS PubMed PubMed Central Google Scholar
Owen, R. P. et al. Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands. Nat. Commun. 9, 4261 (2018).
Article PubMed PubMed Central Google Scholar
Joyce, R. et al. Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers. Nat. Cell Biol. 26, 138–152 (2024).
Article CAS PubMed Google Scholar
Nowicki-Osuch, K. et al. Molecular phenotyping reveals the identity of Barrett’s esophagus and its malignant transition. Science 373, 760–767 (2021).
留言 (0)