Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US); Office on Smoking and Health (US). How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US). 2010. https://www.ncbi.nlm.nih.gov/books/NBK53017/

U.S. Department of Health and Human Services. The Health consequences of Smoking—50 years of progress: a report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2014. [accessed 2016 Dec 20].

Google Scholar 

Vellappally S, Fiala Z, Smejkalová J, Jacob V, Somanathan R. Smoking related systemic and oral diseases. Acta Med (Hradec Kralove). 2007;50(3):161–6.

Article  Google Scholar 

Stämpfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol. 2009;9(5):377–84.

Article  PubMed  Google Scholar 

Eisner MD, Balmes J, Katz PP, Trupin L, Yelin EH. Blanc. Lifetime environmental tobacco smoke exposure and the risk of chronic obstructive pulmonary disease. Environ Health. 2005;4:7.

Article  PubMed  PubMed Central  Google Scholar 

John G, Kohse K, Orasche J, Reda A, Schnelle-Kreis J, Zimmermann R, Schmid O, Eickelberg O. Yildirim. The composition of cigarette smoke determines inflammatory cell recruitment to the lung in COPD mouse models. Clin Sci (Lond). 2014;126:207–21.

Article  PubMed  CAS  Google Scholar 

Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. J Immunol. 2014;192(11):5226–35.

Article  PubMed  CAS  Google Scholar 

Bhat TA, Panzica L, Kalathil SG, Thanavala Y. Immune dysfunction in patients with chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2015;12(suppl 2):S169–75.

Article  PubMed  PubMed Central  Google Scholar 

Bhat TA, Kalathil SG, Bogner PN, Miller A, Lehmann PV, Thatcher TH, et al. Secondhand smoke induces inflammation and impairs immunity to respiratory infections. J Immunol. 2018;200(8):2927–40.

Article  PubMed  CAS  Google Scholar 

Phillip Morris International (PMI). 2022. https://www.pmi.com/smoke-free-products/iqos-our-tobacco-heating-system. Page Assessed July, 2024.

Pouly S, Ng WT, Benzimra M, Soulan A, Blanc N, Zanetti F, Picavet P, Baker G, Haziza C. Effect of switching to the Tobacco Heating System Versus continued cigarette smoking on chronic generalized Periodontitis Treatment Outcome: protocol for a Randomized Controlled Multicenter Study. JMIR Res Protoc. 2021;10(1):e15350.

Article  PubMed  PubMed Central  Google Scholar 

Philip Morris International Inc. (PMI) reports 2022 fourth-quarter and full-year results. Feb 9, 2023. https://www.pmi.com/media-center/press-releases/press-details?newsId=25946

FDA Authorizes Marketing of IQOS Tobacco Heating System with. Reduced Exposure Information. 2020. https://www.fda.gov/news-events/press-announcements/fda-authorizes-marketing-iqos-tobacco-heating-system-reduced-exposure-information

IQOS USA: Launch Tracker Posted July 17. 2024. https://www.reuters.com/markets/us/philip-morris-nears-texas-launch-flagship-heated-tobacco-device-2024-03-28/

Iskandar AR, Mathis C, Schlage WK, et al. A systems toxicology approach for comparative assessment: biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures. Toxicol Vitro. 2017;39:29–51.

Article  CAS  Google Scholar 

Phillips B, Szostak J, Titz B, et al. A six-month systems toxicology inhalation/cessation study in ApoE–/– mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes. Food Chem Toxicol. 2019;126:113–41.

Article  PubMed  CAS  Google Scholar 

Haziza C, de La Bourdonnaye G, Donelli A, et al. Reduction in exposure to selected harmful and potentially harmful constituents approaching those observed upon smoking abstinence in smokers switching to the Menthol Tobacco Heating System 2.2 for 3 months (part 1). Nicotine Tob Res. 2020;22(4):539–48.

Article  PubMed  Google Scholar 

Haziza C, de La Bourdonnaye G, Donelli A, et al. Favorable changes in biomarkers of potential harm to reduce the adverse health effects of smoking in smokers switching to the Menthol Tobacco Heating System 2.2 for 3 months (part 2). Nicotine Tob Res. 2020;22(4):549–59.

Article  PubMed  Google Scholar 

Bhat TA, Kalathil SG, Leigh N, Hutson A, Goniewicz ML, Thanavala YM. Do alternative tobacco products induce less adverse respiratory risk than cigarettes? Respir Res. 2023;24(1):261.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nabavizadeh P, Liu J, Havel CM, et al. Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke. Tob Control. 2018;27(suppl 1):s13–9.

Article  PubMed  Google Scholar 

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018;27(suppl 1):s20–5.

Article  PubMed  Google Scholar 

Bhat TA, Kalathil SG, Leigh N, Muthumalage T, Rahman I, Goniewicz ML, Thanavala YM. Acute effects of Heated Tobacco Product (IQOS) Aerosol Inhalation on Lung tissue damage and inflammatory changes in the lungs. Nicotine Tob Res. 2021;23(7):1160–7.

Article  PubMed  CAS  Google Scholar 

Su YC, Jalalvand F, Thegerström J, Riesbeck K. The interplay between Immune Response and bacterial infection in COPD: Focus upon non-typeable Haemophilus influenzae. Front Immunol. 2018;9:2530.

Article  PubMed  PubMed Central  Google Scholar 

Bhat TA, Kalathil SG, Goniewicz ML, Hutson A, Thanavala Y. Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine. Thorax. 2023;78(9):922–32.

Article  PubMed  Google Scholar 

Auer R, Concha-Lozano N, Jacot-Sadowski I, Cornuz J, Berthet A. Heat-not-burn tobacco cigarettes: smoke by any other name. JAMA Intern Med 2017:1050–2.

St Helen G, Jacob Iii P, Nardone N, Benowitz NL. IQOS: examination of Philip Morris International’s claim of reduced exposure. Tob Control. 2018;27(Suppl 1):s30–6.

Article  PubMed  Google Scholar 

Davis B, Williams M, Talbot P. iQOS: evidence of pyrolysis and release of a toxicant from plastic. Tob Control. 2019;28(1):34–41.

Article  PubMed  Google Scholar 

Willemse BWM, Postma DS, Timens W, ten Hacken NHT. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur Respir J. 2004;23:464–76.

Article  PubMed  CAS  Google Scholar 

Wang Y, Luo G, Chen J, Rui J, Zhu J, Hu N, et al. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating milk fat globule-EGF factor 8 (MFG-E8) expressions. Sci Rep. 2017;7:42642.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Malela S, Scott a. Thickett D, Sandhar g. effects of IQOS on macrophage viability and function. ERJ Open Res. 2019;5:PP130.

Google Scholar 

Miyashita L, Liu NM, Padovan M, Grigg JM. iQOS electronic tobacco device increases susceptibility to pneumococcal infection. AJRCCM. 2018;197:A3571.

Google Scholar 

Znyk M, Jurewicz J, Kaleta D. Exposure to Heated Tobacco Products and Adverse Health Effects, a systematic review. Int J Environ Res Public Health. 2021;18(12):6651.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nitta NA, Sato T, Komura M, Yoshikawa H, Suzuki Y, Mitsui A, Kuwasaki E, Takahashi F, Kodama Y, Seyama K, Takahashi K. Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs. Am J Physiol Lung Cell Mol Physiol. 2022;322(5):L699–711.

Article  PubMed  Google Scholar 

Agaku IT, Filippidis FT, Vardavas CI, Odukoya OO, Awopegba AJ, Ayo-Yusuf OA, Connolly GN. Poly-tobacco use among adults in 44 countries during 2008–2012: evidence for an integrative and comprehensive approach in tobacco control. Drug Alcohol Depend. 2014;139:60–70.

Article  PubMed  Google Scholar 

Soneji S, Sargent J, Tanski S. Multiple tobacco product use among US adolescents and young adults. Tob Control. 2016;25(2):174–80.

Article  PubMed  Google Scholar 

Chen DT, Girvalaki C, Mechili EA, Millett C, Filippidis FT. Global patterns and prevalence of Dual and Poly-Tobacco Use: a systematic review. Nicotine Tob Res. 2021;23(11):1816–20.

Article  PubMed  PubMed Central  Google Scholar