CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL

Graff Z, Burke MJ, Gossai N. Novel therapies for pediatric acute lymphoblastic leukemia. Curr Opin Pediatr. 2024;36:64–70.

Article  CAS  PubMed  Google Scholar 

Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, et al. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022;54:1376–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, et al. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019;51:296–307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohki K, Kiyokawa N, Saito Y, Hirabayashi S, Nakabayashi K, Ichikawa H, et al. Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion. Haematologica. 2019;104:128–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Novakova M, Zaliova M, Fiser K, Vakrmanova B, Slamova L, Musilova A, et al. DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch. Haematologica. 2020. https://haematologica.org/article/view/9801.

Hormann FM, Hoogkamer AQ, Beverloo HB, Boeree A, Dingjan I, Wattel MM, et al. NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2. Haematologica. 2019;104:e455–9.

Article  PubMed  PubMed Central  Google Scholar 

Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, et al. Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia. Nat Commun. 2016;7:11790.

Article  PubMed  PubMed Central  Google Scholar 

Takeoka K, Maekawa F, Nakagawa M, Kishimori C, Fukutsuka K, Hayashida M, et al. MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21). J Clin Exp Hematop. 2022;62:258–67.

Article  PubMed  PubMed Central  Google Scholar 

Passet M, Boissel N, Sigaux F, Saillard C, Bargetzi M, Ba I, et al. PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome. Blood. 2019;133:280–4.

Article  CAS  PubMed  Google Scholar 

Marke R, van Leeuwen FN, Scheijen B. The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia. Haematologica. 2018;103:565–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Dai Y, Wu L, Zhang M, Ouyang W, Huang J, et al. Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia. Front Med. 2021;15:347–71.

Article  CAS  PubMed  Google Scholar 

Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ, et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 2010;116:4874–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, et al. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children’s Oncology Group. Blood. 2017;129:3352–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IB de O, Berti E, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36:1720–48.

Article  PubMed  PubMed Central  Google Scholar 

Duffield AS, Mullighan CG, Borowitz MJ. International Consensus Classification of acute lymphoblastic leukemia/lymphoma. Virchows Arch Int J Pathol. 2023;482:11–26.

Article  CAS  Google Scholar 

Izraeli S. Beyond Philadelphia: “Ph-like” B cell precursor acute lymphoblastic leukemias - diagnostic challenges and therapeutic promises. Curr Opin Hematol. 2014;21:289–96.

Article  CAS  PubMed  Google Scholar 

Tasian SK, Loh ML, Hunger SP. Philadelphia chromosome-like acute lymphoblastic leukemia. Blood. 2017;130:2064–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lengline E, Beldjord K, Dombret H, Soulier J, Boissel N, Clappier E. Successful tyrosine kinase inhibitor therapy in a refractory B-cell precursor acute lymphoblastic leukemia with EBF1-PDGFRB fusion. Haematologica. 2013;98:e146–8.

Article  PubMed  PubMed Central  Google Scholar 

Tanasi I, Ba I, Sirvent N, Braun T, Cuccuini W, Ballerini P, et al. Efficacy of tyrosine kinase inhibitors in Ph-like acute lymphoblastic leukemia harboring ABL-class rearrangements. Blood. 2019;134:1351–5.

Article  PubMed  Google Scholar 

den Boer ML, Cario G, Moorman AV, Boer JM, de Groot-Kruseman HA, Fiocco M, et al. Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era: a multicentre, retrospective, cohort study. Lancet Haematol. 2021;8:e55–66.

Article  PubMed  Google Scholar 

Tasian SK. Are we ABL to do better for children with BCR-ABL1-like acute lymphocytic leukaemia? Lancet Haematol. 2021;8:e6–8.

Article  CAS  PubMed  Google Scholar 

Roberts KG, Yang YL, Payne-Turner D, Lin W, Files JK, Dickerson K, et al. Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL. 2017;1:15.

Chiaretti S, Messina M, Foà R. BCR/ABL1-like acute lymphoblastic leukemia: how to diagnose and treat? Cancer. 2019;125:194–204.

Article  CAS  PubMed  Google Scholar 

Mirkowska P, Hofmann A, Sedek L, Slamova L, Mejstrikova E, Szczepanski T, et al. Leukemia surfaceome analysis reveals new disease-associated features. Blood. 2013;121:e149–159.

Article  CAS  PubMed  Google Scholar 

Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9:1783–6.

CAS  PubMed  Google Scholar 

Kalina T, Flores-Montero J, van der Velden VHJ, Martin-Ayuso M, Böttcher S, Ritgen M, et al. EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols. Leukemia. 2012;26:1986–2010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dworzak MN, Buldini B, Gaipa G, Ratei R, Hrusak O, Luria D, et al. AIEOP-BFM consensus guidelines 2016 for flow cytometric immunophenotyping of pediatric acute lymphoblastic leukemia. Cytom B Clin Cytom. 2018;94:82–93.

Article  Google Scholar 

Buldini B, Varotto E, Maurer-Granofszky M, Gaipa G, Schumich A, Brüggemann M, et al. CD371+ pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment. Blood. 2024;143:1738–1751.

Schinnerl D, Mejstrikova E, Schumich A, Zaliova M, Fortschegger K, Nebral K, et al. CD371 cell surface expression: a unique feature of DUX4-rearranged acute lymphoblastic leukemia. Haematologica. 2019;104:e352–5.

Article  CAS  PubMed  Google Scholar 

Shakah H, Tbakhi A, Khudirat S, Abweh RA, Hasasna N, Alwhaidi A, et al. Flow cytometric signature of CD371-positive B-cell acute lymphoblastic leukemia. J Int Med Res. 2023;51:3000605231203842.

Article  CAS  PubMed  Google Scholar 

Newton JG, Horan JT, Newman S, Rossi MR, Ketterling RP, Park SI. CD36-positive B-lymphoblasts predict poor outcome in children with B-lymphoblastic leukemia. Pediatr Dev Pathol. 2017;20:224–31.

Article  PubMed  Google Scholar 

Gupta DG, Varma N, Sharma P, Truica MI, Abdulkadir SA, Singh P, et al. Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B-lineage acute lymphoblastic leukemia: a report of 1021 patients from India. Cancer. 2023;129:3390–404. https://pubmed.ncbi.nlm.nih.gov/37498973/.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif