Front. Oncol.

Sec. Surgical Oncology

Volume 14 - 2024 | doi: 10.3389/fonc.2024.1417630

Provisionally accepted

Jinbin Xu 1 Yiyuan Tan 2 Shuntian Gao 1 Weijen Lee 1 Yuedian Ye 1 Gengguo Deng 1 Zhansen Huang 1 Xiaoming Li 1 Jiang Li 1 Samun Cheong 1 Jinming Di 1* 1 Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China 2 Shaoguan First People's Hospital, Shaoguan, China

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Background: This retrospective cohort study and meta-analysis aims to explore the association between microvascular invasion (MVI) and clinicopathologiccal features, as well as survival outcomes of patients with renal cell carcinoma (RCC).The retrospective cohort study included 30 RCC patients with positive MVI and another 75 patients with negative MVI as controls. Clinicopathological features and follow-up data were compiled. The meta-analysis conducted searches on PubMed, Cochrane Library, Web of Science, Embase, and WanFang Data from the beginning to 30 September 2023, for comparative studies relevant to MVI patients. The Newcastle-Ottawa Scale and Egger Test were used to assess the risk of biases and certainty of evidence in the included studies.The cohort study showed that MVI was associated with advanced primary tumor stage, high pathological grades, high tumor size, high clinical symptoms and lymph node invasion (P 0.05). The meta-analysis part included 11 cohort studies. The results confirmed that patients with MVI positive had worse 12 and 60 mo CSS rates (HR12mo = 0.86, 95%CI 0.80-0.92; HR60mo = 0.63, 95% CI 0.55-0.72; P

Keywords: Microvascular invasion, Renal cell carcinoma, Cancer-specific survival, Cohort Studies, Meta-analysis

Received: 19 Apr 2024; Accepted: 26 Sep 2024.

Copyright: © 2024 Xu, Tan, Gao, Lee, Ye, Deng, Huang, Li, Li, Cheong and Di. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jinming Di, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

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