Identification of molecular targets of Hypericum perforatum in blood for major depressive disorder: a machine-learning pharmacological study

Williams JW Jr, Mulrow CD, Chiquette E, Noël PH, Aguilar C, Cornell J. A systematic review of newer pharmacotherapies for depression in adults: evidence report summary. Ann Intern Med. 2000;132:743–56. https://doi.org/10.7326/0003-4819-132-9-200005020-00011.

Article  CAS  PubMed  Google Scholar 

Kato M, Hori H, Inoue T, Iga J, Iwata M, Inagaki T, Shinohara K, Imai H, Murata A, Mishima K, et al. Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis. Mol Psychiatry. 2021;26:118–33. https://doi.org/10.1038/s41380-020-0843-0.

Article  CAS  PubMed  Google Scholar 

Kupfer DJ, Frank E, Phillips ML. Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet (London, England). 2012;379:1045–55. https://doi.org/10.1016/s0140-6736(11)60602-8.

Article  PubMed  Google Scholar 

Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH. Peripheral biomarkers of major depression and antidepressant treatment response: current knowledge and future outlooks. J Affect Disord. 2018;233:3–14. https://doi.org/10.1016/j.jad.2017.07.001.

Article  CAS  PubMed  Google Scholar 

Belujon P, Grace AA. Dopamine system dysregulation in major depressive disorders. Int J Neuropsychopharmacol. 2017;20:1036–46. https://doi.org/10.1093/ijnp/pyx056.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin Y, Cui R, Zhao L, Fan J, Li B. Mechanisms of Panax ginseng action as an antidepressant. Cell Prolif. 2019;52: e12696. https://doi.org/10.1111/cpr.12696.

Article  PubMed  PubMed Central  Google Scholar 

Tartt AN, Mariani MB, Hen R, Mann JJ, Boldrini M. Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Mol Psychiatry. 2022;27:2689–99. https://doi.org/10.1038/s41380-022-01520-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020;107:234–56. https://doi.org/10.1016/j.neuron.2020.06.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiat. 2009;65:732–41. https://doi.org/10.1016/j.biopsych.2008.11.029.

Article  CAS  PubMed  Google Scholar 

Milaneschi Y, Allers KA, Beekman ATF, Giltay EJ, Keller S, Schoevers RA, Süssmuth SD, Niessen HG, Penninx B. The association between plasma tryptophan catabolites and depression: the role of symptom profiles and inflammation. Brain Behav Immun. 2021;97:167–75. https://doi.org/10.1016/j.bbi.2021.07.007.

Article  CAS  PubMed  Google Scholar 

Haixia W, Shu M, Li Y, Panpan W, Kehuan S, Yingquan X, Hengrui L, Xiaoguang L, Zhidi W, Ling O. Effectiveness associated with different therapies for senile osteoporosis: a network meta-analysis. J Trad Chin Med. 2020;40:17–27.

Google Scholar 

Hengrui L. An example of toxic medicine used in Traditional Chinese Medicine for cancer treatment. J Tradit Chin Med. 2023;43:209.

PubMed  Google Scholar 

Liu H, Xiong Y, Wang H, Yang L, Wang C, Liu X, Wu Z, Li X, Ou L, Zhang R. Effects of water extract from epimedium on neuropeptide signaling in an ovariectomized osteoporosis rat model. J Ethnopharmacol. 2018;221:126–36.

Article  CAS  PubMed  Google Scholar 

Liu H, Xiong Y, Zhu X, Gao H, Yin S, Wang J, Chen G, Wang C, Xiang L, Wang P. Icariin improves osteoporosis, inhibits the expression of PPARγ, C/EBPα, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats. Exp Ther Med. 2017;13:1360–8.

Article  PubMed  PubMed Central  Google Scholar 

Ou L, Liu HR, Shi XY, Peng C, Zou YJ, Jia JW, Li H, Zhu ZX, Wang YH, Su BM, et al. Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway. J Ethnopharmacol. 2024;320: 117428. https://doi.org/10.1016/j.jep.2023.117428.

Article  CAS  PubMed  Google Scholar 

Ou L, Zhu Z, Hao Y, Li Q, Liu H, Chen Q, Peng C, Zhang C, Zou Y, Jia J, et al. 1,3,6-Trigalloylglucose: a novel potent anti-Helicobacter pylori adhesion agent derived from aqueous extracts of Terminalia chebula Retz. Molecules. 2024;29:1161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng C, Feng Z, Ou L, Zou Y, Sang S, Liu H, Zhu W, Gan G, Zhang G, Yao M. Syzygium aromaticum enhances innate immunity by triggering macrophage M1 polarization and alleviates Helicobacter pylori-induced inflammation. J Funct Foods. 2023;107: 105626.

Article  CAS  Google Scholar 

Wu Z, Ou L, Wang C, Yang L, Wang P, Liu H, Xiong Y, Sun K, Zhang R, Zhu X. Icaritin induces MC3T3-E1 subclone14 cell differentiation through estrogen receptor-mediated ERK1/2 and p38 signaling activation. Biomed Pharmacother. 2017;94:1–9.

Article  CAS  PubMed  Google Scholar 

Hengrui L. Toxic medicine used in Traditional Chinese Medicine for cancer treatment: are ion channels involved? J Tradit Chin Med. 2022;42:1019.

PubMed  Google Scholar 

Linde K, Mulrow CD, Berner M, Egger M. St John’s wort for depression. Cochrane Database Syst Rev. 2005. https://doi.org/10.1002/14651858.CD000448.pub2.

Article  PubMed  Google Scholar 

Linde K, Berner MM, Kriston L. St John’s wort for major depression. Cochrane Database Syst Rev. 2008. https://doi.org/10.1002/14651858.CD000448.pub3.

Article  PubMed  PubMed Central  Google Scholar 

Davis AP, Wiegers TC, Wiegers J, Wyatt B, Johnson RJ, Sciaky D, Barkalow F, Strong M, Planchart A, Mattingly CJ. CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health. Toxicol Sci. 2023;195:155–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piñero J, Ramírez-Anguita JM, Saüch-Pitarch J, Ronzano F, Centeno E, Sanz F, Furlong LI. The DisGeNET knowledge platform for disease genomics: 2019 update. Nucleic Acids Res. 2020;48:D845–55.

PubMed  Google Scholar 

Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y. The GeneCards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinf. 2016;54:1.30.31-31.30.33.

Article  Google Scholar 

Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminf. 2014;6:13. https://doi.org/10.1186/1758-2946-6-13.

Article  CAS  Google Scholar 

Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinform. 2003;4:2. https://doi.org/10.1186/1471-2105-4-2.

Article  Google Scholar 

Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33:1.

Article  PubMed  PubMed Central  Google Scholar 

Sanz H, Valim C, Vegas E, Oller JM, Reverter F. SVM-RFE: selection and visualization of the most relevant features through non-linear kernels. BMC Bioinform. 2018;19:1–18.

Article  Google Scholar 

Leday GG, Vértes PE, Richardson S, Greene JR, Regan T, Khan S, Henderson R, Freeman TC, Pariante CM, Harrison NA. Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biol Psychiat. 2018;83:70–80.

Article  CAS  PubMed  Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43: e47. https://doi.org/10.1093/nar/gkv007.

Article  CAS  PubMed  Google

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