Rapid increase of C/EBPα p42 induces growth arrest of acute myeloid leukemia (AML) cells by Cop1 deletion in Trib1-expressing AML

Bassermann F, Eichner R, Pagano M. The ubiquitin proteasome system – implications for cell cycle control and the targeted treatment of cancer. Biochim Biophys Acta. 2014;1843:150–62.

Article  CAS  PubMed  Google Scholar 

Hynes-Smith RW, Wittorf KJ, Buckley SM. Regulating of normal and malignant hematopoiesis by FBOX ubiquitin E3 ligases. Trends Immunol. 2020;41:1128–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morreale FE, Walden H. Types of ubiquitin ligases. Cell. 2016;165:248–248.e1.

Article  CAS  PubMed  Google Scholar 

Aoki Y, Matsubara Y. Ras/MAPK syndromes and childhood hemato-oncological diseases. Int J Hematol. 2013;97:30–6.

Article  CAS  PubMed  Google Scholar 

Leardini D, Messelodi D, Muratore E, Baccelli F, Beruccio SN, Anselmi L, et al. Role of CBL mutations in cancer and non-malignant phenotype. Cancers. 2022;14:839.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, et al. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell. 2022;29:298–314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sunami Y, Yokoyama T, Yoshino S, Takahara T, Yamazaki Y, Harada H, et al. BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes. Blood Adv. 2022;6:1827–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Weng H, Su R, Zuo Z, Li C, Huang H, et al. FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell. 2017;31:124–41.

Article  Google Scholar 

Yi C, Wang H, Wei N, Deng XW. An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol. 2002;3:30.

Article  PubMed  PubMed Central  Google Scholar 

Eyers PA, Keeshan K, Kannan N. Tribbles in the 21st century: The evolving roles of tribbles pseudokinases in biology and disease. Trends Cell Biol. 2017;27:284–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rorth P, Szabo K, Texido G. The level of C/EBP proteins is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Mol Cell. 2000;6:23–30.

Article  CAS  PubMed  Google Scholar 

Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, et al. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med. 2007;204:2233–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, et al. TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol. 2014;52:145–58.

Article  CAS  PubMed  Google Scholar 

Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, et al. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature. 2013;495:524–8.

Article  CAS  PubMed  Google Scholar 

Mack EA, Stein SJ, Rome KS, Xu L, Wertheim GB, Melo RCN, et al. Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program. Blood. 2019;133:2413–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, et al. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. J Exp Med. 2020;217:e20190888.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, et al. Tribbles homolog 2 inactivates C/EBPalpha and cause acute myelogenous leukemia. Cancer Cell. 2006;10:401–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, et al. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and in duce acute myelogenous leukemia. Blood. 2010;116:1321–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yokoyama T, Kanno Y, Yamazaki Y, Takahara T, Miyata S, Nakamura T. Trib1 links the MERK1/ERK pathway in myeloid leukemogenesis. Blood. 2010;116:2768–75.

Article  CAS  PubMed  Google Scholar 

Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, et al. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 2010;116:4948–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yokoyama T, Nakamura T. Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation. Cancer Sci. 2011;102:1115–22.

Article  CAS  PubMed  Google Scholar 

Murphy JM, Nakatani Y, Jamieson SA, Dai W, Lucet IS, Mace PD. Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase. Structure. 2015;23:2111–21.

Article  CAS  PubMed  Google Scholar 

Kung JE, Jura N. The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export. EMBO J. 2019;38:e99708.

Article  PubMed  PubMed Central  Google Scholar 

Jin G, Yamazaki Y, Takuwa M, Takahara T, Kaneko K, Kuwata T, et al. Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. Blood. 2007;109:3998–4005.

Article  CAS  PubMed  Google Scholar 

Yoshino S, Yokoyama T, Sunami Y, Takahara T, Nakamura A, Yamazaki Y, et al. Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9. Blood. 2021;137:75–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, et al. Restoration of p53 function leads to tumour regression in vivo. Nature. 2007;445:661–5.

Article  CAS  PubMed  Google Scholar 

Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, et al. MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. J Clin Invest. 2016;126:1664–78.

Article  PubMed  PubMed Central  Google Scholar 

Emig D, Salomonis N, Baumbach J, Lengauer T, Conklin BR, Albrecht M. AltAnalyze and DomainGraph: analyzing and visualizing exon expression data. Nucleic Acids Res. 2010;38:Supple:W755–62.

Article  Google Scholar 

Bray NL, Pimentel H, Melsted P, Pachter L. Near optimal probabilistic RNA-seq quantification. Nat Biotechnol. 2016;34:525–7.

Article  CAS  PubMed  Google Scholar 

Subramanian A, Kuehn H, Gould J, Tamayo P, Mesirov JP. GSEA-P: a desktop application for gene set enrichment analysis. Bioinformatics. 2007;23::3251–3.

Article  PubMed 

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