Attia SM (2010) Deleterious effects of reactive metabolites. Oxid Med Cell Longev 3:238–253. https://doi.org/10.4161/oxim.3.4.13246

Article  PubMed  Google Scholar 

Bertelsen B, Stefánsson H, Riff Jensen L et al (2016) Association of AADAC deletion and Gilles de la Tourette syndrome in a large European cohort. Biol Psychiatry 79:383–391. https://doi.org/10.1016/j.biopsych.2015.08.027

Article  CAS  PubMed  Google Scholar 

Bonaccorsi di Patti MC, Cutone A, Polticelli F et al (2018) The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin. Biometals 3:399–414. https://doi.org/10.1007/s10534-018-0087-5

Article  CAS  Google Scholar 

Cao L, Waldon D, Teffera Y, Roberts J et al (2013) Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice. Anal Bioanal Chem 405:2635–2642. https://doi.org/10.1007/s00216-012-6661-8

Article  CAS  PubMed  Google Scholar 

Dara L, Johnson H, Suda J et al (2015) Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology 62:1847–1857. https://doi.org/10.1002/hep.27939/suppinfo

Article  CAS  PubMed  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072. https://doi.org/10.1016/j.cell.2012.03.042

Article  CAS  PubMed  Google Scholar 

Feng J, He H (2022) Signature of arylacetamide deacetylase expression is associated with prognosis and immune infiltration in ovarian cancer. Obstet Gynecol Sci 65:52–63. https://doi.org/10.5468/ogs.21237

Article  PubMed  Google Scholar 

Fukami T, Iida A, Konishi K et al (2016) Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol 116:153–161. https://doi.org/10.1016/j.bcp.2016.07.007

Article  CAS  PubMed  Google Scholar 

Fukami T, Yokoi T, Nakajima M (2022) Non-P450 drug-metabolizing enzymes: contribution to drug disposition, toxicity, and development. Annu Rev Pharmacol Toxicol 64:405–425. https://doi.org/10.1146/annurev-pharmtox-052220-105907

Article  CAS  Google Scholar 

Hirosawa K, Fukami T, Tashiro K et al (2021) Role of human arylacetamide deacetylase (AADAC) on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity. Drug Metab Dispos 49:322–329. https://doi.org/10.1124/dmd.120.000295

Article  CAS  PubMed  Google Scholar 

Itoh K, Chiba T, Takahashi S et al (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313–322. https://doi.org/10.1006/bbrc.1997.6943

Article  CAS  PubMed  Google Scholar 

Jaeschke H, Duan L, Akakpo JY et al (2018) The role of apoptosis in acetaminophen hepatotoxicity. Food Chem Toxicol 118:709–718. https://doi.org/10.1016/j.fct.2018.06.025

Article  CAS  PubMed  Google Scholar 

Katarey D, Verma S (2016) Drug-induced liver injury. Clin Med 16:104–109. https://doi.org/10.7861/clinmedicine.16-6-s104

Article  Google Scholar 

Kobayashi Y, Fukami T, Higuchi R et al (2012a) Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. Biochem Pharmacol 84:1196–1206. https://doi.org/10.1016/j.bcp.2012.08.015

Article  CAS  PubMed  Google Scholar 

Kobayashi Y, Fukami T, Nakajima A et al (2012b) Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse. Drug Metab Dispos 40:671–679. https://doi.org/10.1124/dmd.111.043067

Article  CAS  PubMed  Google Scholar 

Li S, Tan HY, Wang N et al (2015) The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci 16:26087–26124. https://doi.org/10.3390/ijms161125942

Article  CAS  PubMed  Google Scholar 

Liu Y, Chen W, Cen Y et al (2023) Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: involvement of the HIF-1α/SLC7A11/GPX4 axis. Chem Biol Interact 376:110439. https://doi.org/10.1016/j.cbi.2023.110439

Article  CAS  PubMed  Google Scholar 

Manyike PT, Kharasch ED, Kalhorn TF et al (2000) Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin Pharmacol Ther 67:275–282. https://doi.org/10.1067/mcp.2000.104736

Article  CAS  PubMed  Google Scholar 

Mohri T, Nakajima M, Fukami T et al (2010) Human CYP2E1 is regulated by miR-378. Biochem Pharmacol 79:1045–1052. https://doi.org/10.1016/j.bcp.2009.11.015

Article  CAS  PubMed  Google Scholar 

Nagaoka M, Fukami T, Kisui F et al (2022) Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency. Biochem Pharmacol 195:114842. https://doi.org/10.1016/j.bcp.2021.114842

Article  CAS  PubMed  Google Scholar 

Nagaoka M, Sakai Y, Nakajima M et al (2024) Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology. Biochem Pharmacol 223:116128. https://doi.org/10.1016/j.bcp.2024.116128

Article  CAS  PubMed  Google Scholar 

Nakajima A, Fukami T, Kobayashi Y et al (2011) Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine. Biochem Pharmacol 82:1747–1756. https://doi.org/10.1016/j.bcp.2011.08.003

Article  CAS  PubMed  Google Scholar 

Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358. https://doi.org/10.1016/0003-2697(79)90738-3

Article  CAS  PubMed  Google Scholar 

Probst MR, Beer M, Beer D et al (1994) Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. J Biol Chem 34:21650–21656. https://doi.org/10.1016/S0021-9258(17)31855-0

Article  Google Scholar 

Puchkova LV, Aleĭnikova TD, Verbina IA et al (1993) Biosynthesis of two molecular forms of ceruloplasmin in rat liver and their polar secretion into the blood stream and bile. Biokhimiia 58:1893–1901

CAS  PubMed  Google Scholar 

Ramachandran A, Jaeschke H (2019) Acetaminophen hepatotoxicity. Semin Liver Dis 39:221–234. https://doi.org/10.1055/s-0039-1679919

Article  CAS  PubMed  Google Scholar 

Rodriguez RJ, Acosta D Jr (1997) N-Deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes. Toxicity 117:123–131. https://doi.org/10.1016/S0300-483X(96)03560-3

Article  CAS  Google Scholar 

Scholten D, Trebicka J, Liedtke C et al (2015) The carbon tetrachloride model in mice. Lab Anim 49:4–11. https://doi.org/10.1177/0023677215571192

Article  CAS  PubMed  Google Scholar 

Schratter M, Lass A, Radner FPW (2022) ABHD5-A regulator of lipid metabolism essential for diverse cellular functions. Metabolites 12:1015. https://doi.org/10.3390/metabo12111015

Article  CAS  PubMed  Google Scholar 

Shang Y, Luo M, Yao F et al (2020) Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells. Cell Signal 72:109633. https://doi.org/10.1016/j.cellsig.2020.109633

Article  CAS  PubMed