WHO. Update to Requirements for Reporting COVID-19 Surveillance Data under the International Health Regulations (IHR 2005): Addendum to Public Health Surveillance for COVID-19 Interim Guidance, 25 August 2023. Geneva, Switzerland: World Health Organization; 2023.

Taquet M, Dercon Q, Luciano S, Geddes JR, Husain M, Harrison PJ. Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Med. 2021;18:e1003773.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perlis RH, Santillana M, Ognyanova K, Safarpour A, Lunz Trujillo K, Simonson MD, et al. Prevalence and correlates of long COVID symptoms among US adults. JAMA Netw open. 2022;5:e2238804–e2238804.

Article  PubMed  PubMed Central  Google Scholar 

Jaywant A, Gunning FM, Oberlin LE, Santillana M, Ognyanova K, Druckman JN, et al. Cognitive Symptoms of Post–COVID-19 Condition and Daily Functioning. JAMA Netw Open. 2024;7:e2356098–e2356098.

Article  PubMed  PubMed Central  Google Scholar 

Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM, et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun. 2022;101:93–135.

Article  CAS  PubMed  Google Scholar 

Cheetham NJ, Penfold R, Giunchiglia V, Bowyer V, Sudre CH, Canas LS, et al. The effects of COVID-19 on cognitive performance in a community-based cohort: a COVID symptom study biobank prospective cohort study. EClinicalMedicine. 2023;62:102086.

Article  PubMed  PubMed Central  Google Scholar 

Peter RS, Nieters A, Kräusslich H-G, Brockmann SO, Göpel S, Kindle G, et al. Post-acute sequelae of covid-19 six to 12 months after infection: population based study. bmj. 2022;379:e071050.

Article  PubMed  Google Scholar 

Hampshire A, Azor A, Atchison C, Trender W, Hellyer PJ, Giunchiglia V, et al. Cognition and Memory after Covid-19 in a Large Community Sample. N Engl J Med. 2024;390:806–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng N, Zhao Y-M, Yan W, Li C, Lu QD, Liu L, et al. A systematic review and meta-analysis of long term physical and mental sequelae of COVID-19 pandemic: call for research priority and action. Mol Psychiatry. 2023;28:423–33.

Article  CAS  PubMed  Google Scholar 

Hall PA, Meng G, Hudson A, Sakib MN, Hitchman SC, MacKillop J, et al. Cognitive function following SARS-CoV-2 infection in a population-representative Canadian sample. Brain Behav Immun Health. 2022;21:100454.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertuccelli M, Ciringione L, Rubega M, Bisiacchi P, Masiero S, Del Felice A. Cognitive impairment in people with previous COVID-19 infection: A scoping review. Cortex. 2022;154:212–30.

Article  PubMed  PubMed Central  Google Scholar 

Lamontagne SJ, Winters MF, Pizzagalli DA, Olmstead MC. Post-acute sequelae of COVID-19: Evidence of mood & cognitive impairment. Brain Behav Immun Health. 2021;17:100347.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jaywant A, Vanderlind WM, Alexopoulos GS, Fridman CB, Perlis RH, Gunning FM. Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19. Neuropsychopharmacology. 2021;46:2235–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malik P, Patel K, Pinto C, Jaiswal R, Tirupathi R, Pillai S, et al. Post‐acute COVID‐19 syndrome (PCS) and health‐related quality of life (HRQoL)—A systematic review and meta‐analysis. J Med Virol. 2022;94:253–62.

Article  CAS  PubMed  Google Scholar 

Tabacof L, Tosto-Mancuso J, Wood J, Cortes M, Kontorovich A, McCarthy D, et al. Post-acute COVID-19 syndrome negatively impacts physical function, cognitive function, health-related quality of life, and participation. Am J Phys Med Rehabil. 2022;101:48–52.

Article  PubMed  Google Scholar 

Quan M, Wang X, Gong M, Wang Q, Li Y, Jia J. Post-COVID cognitive dysfunction: current status and research recommendations for high risk population. Lancet Reg Heal Pacific. 2023;38:100836.

Fesharaki Zadeh A, Arnsten AFT, Wang M. Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID. Neurol Int. 2023;15:725–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Möller M, Borg K, Janson C, Lerm M, Normark J, Niward K. Cognitive dysfunction in post‐COVID‐19 condition: Mechanisms, management, and rehabilitation. J Intern Med. 2023;294:563–81.

Article  PubMed  Google Scholar 

Victor MM, Müller Haas L, Grevet EH, Rohde LA. Successful Treatment of Post-COVID-19 ADHD-like Syndrome: A Case Report. J Atten Disord. 2023;27:1092–98.

Manu P. Repurposing Drugs for Post–COVID-19 Fatigue Syndrome: Methylphenidate, Duloxetine, and Brexpiprazole. Am J Ther. 2022;29:e229–e230.

Article  PubMed  Google Scholar 

Sacks-Zimmerman A, Bergquist TF, Farr EM, Cornwell MA, Kanellopoulos D. Rehabilitation of Neuropsychiatric Symptoms in Patients With Long COVID: Position Statement. Arch Phys Med Rehabil. 2023;104:350–4.

Article  PubMed  Google Scholar 

van der Ham IJM, van der Vaart R, Miedema A, Visser-Meily JMA, van der Kuil MNA. Healthcare professionals’ acceptance of digital cognitive rehabilitation. Front Psychol. 2020;11:617886.

Article  PubMed  PubMed Central  Google Scholar 

Chiaravalloti ND, Alexander A. Crossing the synapse: Strengthening the connection between clinical research and clinical practice of cognitive rehabilitation. Front Rehabil Sci. 2023;4:1084071.

Kollins SH, DeLoss DJ, Cañadas E, Lutz J, Findling RL, Keefe R, et al. A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial. Lancet Digit Heal. 2020;2:e168–e178.

Article  Google Scholar 

Keefe RSE, Cañadas E, Farlow D, Etkin A. Digital intervention for cognitive deficits in major depression: a randomized controlled trial to assess efficacy and safety in adults. Am J Psychiatry. 2022;179:482–9.

Article  PubMed  Google Scholar 

Bove R, Rowles W, Zhao C, Anderson A, Friedman S, Langdon D, et al. A novel in-home digital treatment to improve processing speed in people with multiple sclerosis: a pilot study. Mult Scler J. 2021;27:778–89.

Article  CAS  Google Scholar 

Davis NO, Bower J, Kollins SH. Proof-of-concept study of an at-home, engaging, digital intervention for pediatric ADHD. PLoS One. 2018;13:e0189749.

Article  PubMed  PubMed Central  Google Scholar 

Anguera JA, Brandes-Aitken AN, Antovich AD, Rolle CE, Desai SS, Marco EJ. A pilot study to determine the feasibility of enhancing cognitive abilities in children with sensory processing dysfunction. PLoS One. 2017;12:e0172616.

Article  PubMed  PubMed Central  Google Scholar 

Anguera JA, Gunning FM, Areán PA. Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial. Depress Anxiety. 2017;34:508–17. https://doi.org/10.1002/da.22588

Article  PubMed  PubMed Central  Google Scholar 

Gunning FM, Anguera JA, Victoria LW, Areán PA. A digital intervention targeting cognitive control network dysfunction in middle age and older adults with major depression. Transl Psychiatry. 2021;11. https://doi.org/10.1038/s41398-021-01386-8

Kollins SH, Childress A, Heusser AC, Lutz J. Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD. NPJ Digit Med. 2021;4:58.

Article  PubMed  PubMed Central  Google Scholar 

Stamatis CA, Mercaldi C, Kollins SH. A Single-Arm Pivotal Trial to Assess the Efficacy of Akl-T01, a Novel Digital Intervention for Attention, in Adults Diagnosed With ADHD. J Am Acad Child Adolesc Psychiatry. 2023;62:S318.

Article  Google Scholar 

Stroop J. Studies of interference in serial verbal reactions. J Exp Psychol. 1935;18:643–62. https://doi.org/10.1037/h0054651

Article  Google Scholar 

Golden C, Freshwater SM, Golden Z. Stroop color and word test: A manual for clinical and experimental uses. Chicago, Illinois: Stoelting Company. 1978;1–32.

Ricker JH, Axelrod BN, Houtler BD. Clinical validation of the oral trail making test. Cogn Behav Neurol. 1996;9:50–53.

Google Scholar 

Mrazik M, Millis S, Drane DL. The oral trail making test: effects of age and concurrent validity. Arch Clin Neuropsychol. 2010;25:236–43.

Article  PubMed  PubMed Central  Google Scholar 

Grace J, Malloy PF. Frontal systems behavior scale: Professional manual. Lutz, Florida: Psychological Assessment Resources. 2001.

Leong V, Raheel K, Sim JY, Kacker K, Karlaftis VM, Vassiliu C, et al. A new remote guided method for supervised web-based cognitive testing to ensure high-quality da