KECORT Study: An International e-Delphi Study on the Treatment of KEloids Using Intralesional CORTicosteroids in Clinical Practice

Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110:560–71.

Article  PubMed  Google Scholar 

Ogawa R, Akita S, Akaishi S, Aramaki-Hattori N, Dohi T, Hayashi T, et al. Diagnosis and treatment of keloids and hypertrophic scars-Japan scar workshop consensus document 2018. Burns Trauma. 2019;7:39.

Article  PubMed  PubMed Central  Google Scholar 

Wang CJ, Ko JY, Chou WY, Cheng JH, Kuo YR. Extracorporeal shockwave therapy for treatment of keloid scars. Wound Repair Regen. 2018;26:69–76.

Article  PubMed  Google Scholar 

Kaushal V, Kumar S, Brar BK, Singh A. Comparative evaluation of therapeutic efficacy and safety of intralesional triamcinolone acetonide injection vs intralesional radiofrequency with intralesional triamcinolone acetonide in treatment of keloids. Dermatol Ther. 2020;33: e13919.

Article  CAS  PubMed  Google Scholar 

Yin Q, Louter JMI, Niessen FB, Gibbs S, Tasdemir-Kilic G, Lapid O, et al. Intralesional corticosteroid administration in the treatment of keloids: a scoping review on injection methods. Dermatology. 2023.

Yin Q, Niessen FB, Gibbs S, Lapid O, Louter JMI, van Zuijlen PPM, Wolkerstorfer A. Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons. J Dermatolog Treat. 2023;34:2159308.

Article  PubMed  Google Scholar 

Diamond IR, Grant RC, Feldman BM, Pencharz PB, Ling SC, Moore AM, Wales PW. Defining consensus: a systematic review recommends methodologic criteria for reporting of Delphi studies. J Clin Epidemiol. 2014;67:401–9.

Article  PubMed  Google Scholar 

Wang X, Wu X, Liu K, Xia L, Lin X, Liu W, Gao Z. Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids. Medicine (Baltimore). 2017;96: e8353.

Article  PubMed  Google Scholar 

Jongkajornpong N WK. The efficacy of skin cooling for pain relief during intralesional steroid injection for keloid treatment: a randomized cross-over study. J Med Assoc Thailand. 2021:1752–7.

Limandjaja GC, van den Broek LJ, Waaijman T, van Veen HA, Everts V, Monstrey S, et al. Increased epidermal thickness and abnormal epidermal differentiation in keloid scars. Br J Dermatol. 2017;176:116–26.

Article  CAS  PubMed  Google Scholar 

Jiao H, Zhang T, Fan J, Xiao R. The superficial dermis may initiate keloid formation: histological analysis of the keloid dermis at different depths. Front Physiol. 2017;8:885.

Article  PubMed  PubMed Central  Google Scholar 

Syed F, Ahmadi E, Iqbal SA, Singh S, McGrouther DA, Bayat A. Fibroblasts from the growing margin of keloid scars produce higher levels of collagen I and III compared with intralesional and extralesional sites: clinical implications for lesional site-directed therapy. Br J Dermatol. 2011;164:83–96.

Article  CAS  PubMed  Google Scholar 

Simpson RC, Kirtschig G, Selk A, von Seitzberg S, Vittrup G, Bissonnette I, et al. Core outcome domains for lichen sclerosus: a CORALS initiative consensus statement. Br J Dermatol. 2023;188:628–35.

Article  PubMed  Google Scholar 

Young AM, Chung H, Chaplain A, Lowe JR, Wallace SJ. Development of a minimum dataset for subacute rehabilitation: a three-round e-Delphi consensus study. BMJ Open. 2022;12: e058725.

Article  PubMed  PubMed Central  Google Scholar 

Mirmovich O, Gil T, Goldin I, Lavi I, Mettanes I, Har-Shai Y. Pain evaluation and control during and following the treatment of hypertrophic scars and keloids by contact and intralesional cryosurgery—a preliminary study. J Eur Acad Dermatol Venereol. 2012;26:440–7.

Article  CAS  PubMed  Google Scholar 

Searle T, Ali FR, Al-Niaimi F. The role of pharmacogenetics in keloid scar treatment: a literature review. Scars Burn Heal. 2020;6:2059513120941704.

PubMed  PubMed Central  Google Scholar 

Furtado F, Hochman B, Ferrara SF, Dini GM, Nunes JM, Juliano Y, Ferreira LM. What factors affect the quality of life of patients with keloids? Rev Assoc Med Bras. 1992;2009(55):700–4.

Google Scholar 

Bijlard E, Kouwenberg CA, Timman R, Hovius SE, Busschbach JJ, Mureau MA. Burden of keloid disease: a cross-sectional health-related quality of life assessment. Acta Derm Venereol. 2017;97:225–9.

Article  PubMed  Google Scholar 

Bari H. A prolonged release parenteral drug delivery system—an overview. Int J Pharm Sci Rev Res. 2010;3:1–11.

CAS  Google Scholar 

Benzon HT, Chew TL, McCarthy RJ, Benzon HA, Walega DR. Comparison of the particle sizes of different steroids and the effect of dilution: a review of the relative neurotoxicities of the steroids. Anesthesiology. 2007;106:331–8.

Article  CAS  PubMed  Google Scholar 

Firooz A, Tehranchi-Nia Z, Ahmed AR. Benefits and risks of intralesional corticosteroid injection in the treatment of dermatological diseases. Clin Exp Dermatol. 1995;20:363–70.

Article  CAS  PubMed  Google Scholar 

MacMahon PJ, Shelly MJ, Scholz D, Eustace SJ, Kavanagh EC. Injectable corticosteroid preparations: an embolic risk assessment by static and dynamic microscopic analysis. AJNR Am J Neuroradiol. 2011;32:1830–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tiso RL, Cutler T, Catania JA, Whalen K. Adverse central nervous system sequelae after selective transforaminal block: the role of corticosteroids. Spine J. 2004;4:468–74.

Article  PubMed  Google Scholar 

Kahn CB, Hollander JL, Schumacher HR. Corticosteroid crystals in synovial fluid. JAMA. 1970;211:807–9.

Article  CAS  PubMed  Google Scholar 

Woliansky J, Phyland D, Paddle P. Systemic safety of serial intralesional steroid injection for subglottic stenosis. Laryngoscope. 2019;129:1634–9.

Article  CAS  PubMed  Google Scholar 

Cevc G, Blume G. Biological activity and characteristics of triamcinolone-acetonide formulated with the self-regulating drug carriers. Transfersomes Biochim Biophys Acta. 2003;1614:156–64.

Article  CAS  PubMed  Google Scholar 

Spitzer MS, Kaczmarek RT, Yoeruek E, Petermeier K, Wong D, Heimann H, et al. The distribution, release kinetics, and biocompatibility of triamcinolone injected and dispersed in silicone oil. Invest Ophthalmol Vis Sci. 2009;50:2337–43.

Article  PubMed  Google Scholar 

Fernandes-Cunha GM, Saliba JB, Siqueira RC, Jorge R, Silva-Cunha A. Determination of triamcinolone acetonide in silicone oil and aqueous humor of vitrectomized rabbits’ eyes: application for a pharmacokinetic study with intravitreal triamcinolone acetonide injections (Kenalog® 40). J Pharm Biomed Anal. 2014;89:24–7.

Article  CAS  PubMed  Google Scholar 

Li J, Lee K, Chang D, Boominathan P, Banack T. A breast cancer survivor’s self-controlled case report: methylprednisolone acetate provided a week longer analgesia than dexamethasone sodium phosphate via thoracic paravertebral blockade. Cureus. 2019;11: e6085.

PubMed  PubMed Central  Google Scholar 

Jobe AH, Milad MA, Peppard T, Jusko WJ. Pharmacokinetics and pharmacodynamics of intramuscular and oral betamethasone and dexamethasone in reproductive age women in India. Clin Transl Sci. 2020;13:391–9.

Article  CAS  PubMed  Google Scholar 

SmPC KenaCort. https://www.geneesmiddeleninformatiebank.nl/smpc/h05341_smpc.pdf.

Jarratt MT, Spark RF, Arndt KA. The effects of intradermal steroids on the pituitary-adrenal axis and the skin. J Invest Dermatol. 1974;62:463–6.

Article  CAS  PubMed  Google Scholar 

Zaynoun ST, Salti IS. The effect of intracutaneous glucocorticoids on plasma cortisol levels. Br J Dermatol. 1973;88:151–6.

Article  CAS  PubMed  Google Scholar 

Mcgugan AD, Shuster S, Bottoms E. Adrenal suppression from intradermal triamcinolone. J Invest Dermatol. 1963;40:271–2.

CAS  Google Scholar 

Samtani MN, Lohle M, Grant A, Nathanielsz PW, Jusko WJ. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab Dispos. 2005;33:1124–30.

Article  CAS  PubMed 

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