Global Tuberculosis Report (World Health Organization, 2023).
Caruso, A. M. et al. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J. Immunol. 162, 5407–5416 (1999).
Article CAS PubMed Google Scholar
Lin, P. L. et al. CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques. AIDS Res. Hum. Retroviruses 28, 1693–1702 (2012).
Article CAS PubMed PubMed Central Google Scholar
Diedrich, C. R. et al. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. PLoS ONE 5, e9611 (2010).
Article PubMed PubMed Central Google Scholar
Maglione, P. J., Xu, J. & Chan, J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J. Immunol. 178, 7222–7234 (2007).
Article CAS PubMed Google Scholar
Hamasur, B. et al. A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab’) fragment prolong survival of mice infected with Mycobacterium tuberculosis. Clin. Exp. Immunol. 138, 30–38 (2004).
Article CAS PubMed PubMed Central Google Scholar
Teitelbaum, R. et al. A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival. Proc. Natl Acad. Sci. USA 95, 15688–15693 (1998).
Article CAS PubMed PubMed Central Google Scholar
Pethe, K. et al. The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature 412, 190–194 (2001).
Article CAS PubMed Google Scholar
Balu, S. et al. A novel human IgA monoclonal antibody protects against tuberculosis. J. Immunol. 186, 3113–3119 (2011).
Article CAS PubMed Google Scholar
Watson, A. et al. Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat. Commun. 12, 602 (2021).
Article CAS PubMed PubMed Central Google Scholar
Li, H. et al. Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 114, 5023–5028 (2017).
Article CAS PubMed PubMed Central Google Scholar
Chen, T. et al. Capsular glycan recognition provides antibody-mediated immunity against tuberculosis. J. Clin. Invest. 130, 1808–1822 (2020).
Article CAS PubMed PubMed Central Google Scholar
Krishnananthasivam, S. et al. An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis. npj Vaccines 8, 127 (2023).
Article CAS PubMed PubMed Central Google Scholar
Chen, T. et al. Association of human antibodies to arabinomannan with enhanced mycobacterial opsonophagocytosis and intracellular growth reduction. J. Infect. Dis. 214, 300–310 (2016).
Article CAS PubMed PubMed Central Google Scholar
Prados-Rosales, R. et al. Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan–protein conjugate vaccine. PLoS Pathog. 13, e1006250 (2017).
Article PubMed PubMed Central Google Scholar
Maglione, P. J., Xu, J., Casadevall, A. & Chan, J. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. J. Immunol. 180, 3329–3338 (2008).
Article CAS PubMed Google Scholar
Lu, L. L. et al. A functional role for antibodies in tuberculosis. Cell 167, 433–443.e14 (2016).
Article CAS PubMed PubMed Central Google Scholar
Sani, M. et al. Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins. PLoS Pathog. 6, e1000794 (2010).
Article PubMed PubMed Central Google Scholar
Lemassu, A. & Daffé, M. Structural features of the exocellular polysaccharides of Mycobacterium tuberculosis. Biochem. J. 297, 351–357 (1994).
Article CAS PubMed PubMed Central Google Scholar
Ortalo-Magné, A. et al. Molecular composition of the outermost capsular material of the tubercle bacillus. Microbiology 141, 1609–1620 (1995).
Schwebach, J. R. et al. Glucan is a component of the Mycobacterium tuberculosis surface that is expressed in vitro and in vivo. Infect. Immun. 70, 2566–2575 (2002).
Article CAS PubMed PubMed Central Google Scholar
Keitel, W. A. et al. Effects of infection and disease with Mycobacterium tuberculosis on serum antibody to glucan and arabinomannan: two surface polysaccharides of this pathogen. BMC Infect. Dis. 13, 276 (2013).
Article CAS PubMed PubMed Central Google Scholar
Yu, X. et al. Comparative evaluation of profiles of antibodies to mycobacterial capsular polysaccharides in tuberculosis patients and controls stratified by HIV status. Clin. Vaccine Immunol. 19, 198–208 (2012).
Article CAS PubMed PubMed Central Google Scholar
Martin, C. J. et al. Efferocytosis is an innate antibacterial mechanism. Cell Host Microbe 12, 289–300 (2012).
Article CAS PubMed PubMed Central Google Scholar
Andreu, N. et al. Optimisation of bioluminescent reporters for use with mycobacteria. PLoS ONE 5, e10777 (2010).
Article PubMed PubMed Central Google Scholar
Gunn, B. M. et al. A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus. Immunity 54, 815–828.e5 (2021).
Article CAS PubMed PubMed Central Google Scholar
Smith, P., DiLillo, D. J., Bournazos, S., Li, F. & Ravetch, J. V. Mouse model recapitulating human Fcγ receptor structural and functional diversity. Proc. Natl Acad. Sci. USA 109, 6181–6186 (2012).
Article CAS PubMed PubMed Central Google Scholar
Shields, R. L. et al. High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J. Biol. Chem. 276, 6591–6604 (2001).
Article CAS PubMed Google Scholar
Lazar, G. A. et al. Engineered antibody Fc variants with enhanced effector function. Proc. Natl Acad. Sci. USA 103, 4005–4010 (2006).
Article CAS PubMed PubMed Central Google Scholar
Idusogie, E. E. et al. Engineered antibodies with increased activity to recruit complement. J. Immunol. 166, 2571–2575 (2001).
留言 (0)