Vinh DC, Rubinstein E (2009) Linezolid: a review of safety and tolerability. J Infect 59(Suppl 1):S59-74
Dresser LD, Rybak MJ (1998) The pharmacologic and bacteriologic properties of oxazolidinones, a new class of synthetic antimicrobials. Pharmacotherapy 18(3):456–462
Article CAS PubMed Google Scholar
Stalker DJ, Jungbluth GL (2003) Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial. Clin Pharmacokinet 42:1129–1140
Article CAS PubMed Google Scholar
World Health Organization (2022) Antimicrobial resistance. Global antimicrobial resistance and use surveillance system (GLASS) report. WHO. Available from: https://www.who.int/en/news-room/fact-sheets/detail/antimicrobial-resistance. Accessed 17 Mar 2024
Almutairi H, Albahadel H, Alhifany A et al (2024) Prevalence and antimicrobial susceptibility pattern of methicillin-resistant Staphylococcus aureus (MRSA) at a maternity and children hospital in Saudi Arabia: A cross-sectional study. Saudi Pharm J 32(4):102001
Article CAS PubMed PubMed Central Google Scholar
Banawas SS, Alobaidi AS, Dawoud TM et al (2023) Prevalence of multidrug-resistant bacteria in healthcare-associated bloodstream infections at hospitals in Riyadh, Saudi Arabia. Pathogens 12(9):1075
Article CAS PubMed PubMed Central Google Scholar
Fang P, Gao K, Yang J et al (2023) Prevalence of multidrug-resistant pathogens causing neonatal early and late onset sepsis, a retrospective study from the tertiary referral children’s hospital. Infect Drug Resist 16:4213–4225
Article CAS PubMed PubMed Central Google Scholar
Mariani M, Parodi A, Minghetti D et al (2022) Early and late onset neonatal sepsis: epidemiology and effectiveness of empirical antibacterial therapy in a III level neonatal intensive care unit. Antibiotics (Basel) 11(2):284
Article CAS PubMed Google Scholar
Shariati A, Dadashi M, Moghadam MT et al (2020) Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis. Sci Rep 10(1):12689
Article CAS PubMed PubMed Central Google Scholar
Belete MA, Gedefie A, Alemayehu E et al (2023) The prevalence of vancomycin-resistant Staphylococcus aureus in Ethiopia: a systematic review and meta-analysis. Antimicrob Resist Infect Control 12(1):86
Article PubMed PubMed Central Google Scholar
Bandín-Vilar E, García-Quintanilla L, Castro-Balado A et al (2022) Review of population pharmacokinetic analyses of linezolid. Clin Pharmacokinet 61(6):789–817
Article PubMed PubMed Central Google Scholar
Linezolid. In: Lexicomp Online (2023) Pediatric & Neonatal Lexi-Drugs. Hudson, OH: Lexi-Comp, Inc. Available from: www.online.lexi.com. Accessed 15 Jan 2023
Matrat L, Plaisant F, Barreto C et al (2020) Increasing use of linezolid in a tertiary NICU during a 10-year period: reasons and concerns for the future. Antimicrob Resist Infect Control 9(1):156
Article PubMed PubMed Central Google Scholar
Buccellato E, Melis M, Biagi C et al (2015) Use of antibiotics in pediatrics: 8-year survey in Italian hospitals. PLoS ONE 10:e0139097
Article PubMed PubMed Central Google Scholar
Bagga B, Buckingham S, Arnold S et al (2018) Increasing linezolid-resistant enterococcus in a children’s hospital. Pediatr Infect Dis J 37:242–244
Hallam MJ, Allen JM, James SE et al (2010) Potential subtherapeutic linezolid and meropenem antibiotic concentrations in a patient with severe burns and sepsis. J Burn Care Res 31:207–209
El-Gaml RM, El-Khodary NM, Abozahra RR et al (2022) Applying pharmacokinetic/pharmacodynamic measurements for linezolid in critically ill patients: optimizing efficacy and reducing resistance occurrence. Eur J Clin Pharmacol 78(8):1301–1310
Article CAS PubMed PubMed Central Google Scholar
Dong H, Wang X, Dong Y et al (2011) Clinical pharmacokinetic/pharmacodynamic profile of linezolid in severely ill intensive care unit patients. Int J Antimicrob Agents 38:296–300
Article CAS PubMed Google Scholar
Galar A, Valerio M, Muñoz P et al (2017) Systematic therapeutic drug monitoring for linezolid: variability and clinical impact. Antimicrob Agents Chemother 61(10):e00687-e717
Article CAS PubMed PubMed Central Google Scholar
Gandelman K, Zhu T, Fahmi OA et al (2011) Unexpected effect of rifampin on the pharmacokinetics of linezolid: in silico and in vitro approaches to explain its mechanism. J Clin Pharmacol 51:229–236
Article CAS PubMed Google Scholar
Bolhuis MS, van Altena R, Uges DR et al (2010) Clarithromycin significantly increases linezolid serum concentrations. Antimicrob Agents Chemother 54:5418–5419
Article CAS PubMed PubMed Central Google Scholar
Pea F, Viale P, Cojutti P et al (2012) Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients. J Antimicrob Chemother 67(8):2034–2042
Article CAS PubMed Google Scholar
Rao GG, Konicki R, Cattaneo D et al (2020) Therapeutic drug monitoring can improve linezolid dosing regimens in current clinical practice: a review of linezolid pharmacokinetics and pharmacodynamics. Ther Drug Monit 42(1):83–92
Lau C, Marriott D, Bui J et al (2023) LInezolid Monitoring to MInimise Toxicity (LIMMIT1): a multicentre retrospective review of patients receiving linezolid therapy and the impact of therapeutic drug monitoring. Int J Antimicrob Agents 61(5):106783
Article CAS PubMed Google Scholar
Cojutti P, Maximova N, Crichiutti G et al (2015) Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation. J Antimicrob Chemother 70(1):198–206
Article CAS PubMed Google Scholar
Lin B, Hu Y, Xu P et al (2022) Expert consensus statement on therapeutic drug monitoring and individualization of linezolid. Front Public Health 10:967311
Article PubMed PubMed Central Google Scholar
Alsultan A (2019) Determining therapeutic trough ranges for linezolid. Saudi Pharm J 27(8):1061–1063
Article CAS PubMed PubMed Central Google Scholar
FDA (2023) Linezolid prescribing information. U.S. Food and Drug Administration. Accessed 15 Jun 2023.
Han X, Wang J, Zan X et al (2022) Risk factors for linezolid-induced thrombocytopenia in adult inpatients. Int J Clin Pharm 44(2):330–338
Article CAS PubMed Google Scholar
Kaya Kılıç E, Bulut C, Sönmezer MÇ et al (2019) Risk factors for linezolid-associated thrombocytopenia and negative effect of carbapenem combination. J Infect Dev Ctries 13(10):886–891
Shi Y, Wu HL, Wu YH et al (2023) Safety and clinical efficacy of linezolid in children: a systematic review and meta-analysis. World J Pediatr 19(2):129–138
Article CAS PubMed Google Scholar
Kato H, Hagihara M, Asai N et al (2021) A systematic review and meta-analysis of myelosuppression in pediatric patients treated with linezolid for Gram-positive bacterial infections. J Infect Chemother 27(8):1143–1150
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