Fowler A, Abbott T, Prowle J, Pearse R. Age of patients undergoing surgery. Br J Surg. 2019;106(8):1012–8. https://doi.org/10.1002/bjs.11148.

Article  CAS  PubMed  Google Scholar 

Kitsis P, Zisimou T, Gkiatas I, Kostas-Agnantis I, Gelalis I, Korompilias A, Pakos E. Postoperative delirium and postoperative cognitive dysfunction in patients with elective hip or knee arthroplasty: a narrative review of the literature. Life. 2022;12(2):314. https://doi.org/10.3390/life12020314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karageorgos V, Mevorach L, Silvetti M, Bilotta F. Preoperative risk factors associated with increased incidence of postoperative delirium: systematic review of qualified clinical studies. Geriatrics. 2023;8(1):24. https://doi.org/10.3390/geriatrics8010024.

Article  PubMed  PubMed Central  Google Scholar 

Abate SM, Checkole YA, Mantedafro B, Basu B, Aynalem AE. Global prevalence and predictors of postoperative delirium among non-cardiac surgical patients: a systematic review and meta-analysis. Int J Surg Open. 2021;32:100334. https://doi.org/10.1016/j.ijso.2021.100334.

Article  Google Scholar 

Bellelli G, Mazzola P, Morandi A, Bruni A, Carnevali L, Corsi M, Zatti G, Zambon A, Corrao G, Olofsson B, Gustafson Y, Annoni G. Duration of postoperative delirium is an independent predictor of 6 month mortality in older adults after hip fracture. J Am Geriatr Soc. 2014;62(7):1335–40. https://doi.org/10.1111/jgs.12885.

Article  PubMed  Google Scholar 

Scholz A, Oldroyd C, McCarthy K, Quinn T, Hewitt J. Systematic review and meta-analysis of risk factors for postoperative delirium among older patients undergoing gastrointestinal surgery. Br J Surg. 2016;103(2):e21–8. https://doi.org/10.1002/bjs.10062.

Article  CAS  PubMed  Google Scholar 

Choi S, Jung I, Yoo B, Lee S, Kim MC. Risk factors for postoperative delirium in elderly patients after spinal fusion surgery. Anesth Pain Med. 2020;15(3):275–82. https://doi.org/10.17085/apm.19092.

Article  Google Scholar 

Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, Cherubini A, Jones C, Kehlet H, MacLullich A, Radtke F, Riese F, Slooter AJC, Veyckemans F, Kramer S, Neuner B, Weiss B, Spies CD. European society of anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesthesiol. 2017;34(4):192–214. https://doi.org/10.1097/eja.0000000000000594.

Article  PubMed  Google Scholar 

Oh S-T, Park JY. Postoperative delirium. Korean J Anesthesiol. 2019;72(1):4–12. https://doi.org/10.4097/kja.d.18.00073.1.

Article  PubMed  Google Scholar 

Jin Z, Hu J, Ma D. Postoperative delirium: perioperative assessment, risk reduction, and management. Br J Anaesth. 2020;125(4):492–504. https://doi.org/10.1016/j.bja.2020.06.063.

Article  PubMed  Google Scholar 

Peden CJ, Miller TR, Deiner SG, Eckenhoff RG, Fleisher LA, Fleisher L, Deiner S, Eckenhoff R, Peden C, Brown I. Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team. Br J Anaesth. 2021;126(2):423–32. https://doi.org/10.1016/j.bja.2020.10.037.

Article  PubMed  Google Scholar 

Evered LA, Pryor KO. Benzodiazepines and postoperative delirium: should we be as cautious as we are? Br J Anaesth. 2023;131(4):629–31. https://doi.org/10.1016/j.bja.2023.07.004.

Article  PubMed  Google Scholar 

Hughes CG, Boncyk CS, Culley DJ, Fleisher LA, Leung JM, McDonagh DL, Gan TJ, McEvoy MD, Miller TE. American society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention. Anesth Analg. 2020;130(6):1572–90. https://doi.org/10.1213/ane.0000000000004641.

Article  PubMed  PubMed Central  Google Scholar 

Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen J-F, Pun BT, Puntillo KA, Riker RR, Robinson BRH, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46(9):e825–73. https://doi.org/10.1097/ccm.0000000000003299.

Article  PubMed  Google Scholar 

Berger M, Schenning KJ, Brown CHt, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z. Best practices for postoperative brain health: recommendations from the fifth international perioperative neurotoxicity working group. Anesth Analg. 2018;127(6):1406–13. https://doi.org/10.1213/ane.0000000000003841.

Article  PubMed  PubMed Central  Google Scholar 

Shin H-J, Woo Nam S, Kim H, Yim S, Han S-H, Hwang J-W, Do S-H, Na H-S. Postoperative delirium after dexmedetomidine versus propofol sedation in healthy older adults undergoing orthopedic lower limb surgery with spinal anesthesia: a randomized controlled trial. Anesthesiology. 2023;138(2):164–71. https://doi.org/10.1097/aln.0000000000004438.

Article  CAS  PubMed  Google Scholar 

Li P, Li L-x, Zhao Z-z, Xie J, Zhu C-l, Deng X-m, Wang J-f. Dexmedetomidine reduces the incidence of postoperative delirium after cardiac surgery: a meta-analysis of randomized controlled trials. BMC Anesthesiol. 2021;21(1):153. https://doi.org/10.1186/s12871-021-01370-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan X, Coburn M, Rossaint R, Sanders RD, Waesberghe JV, Kowark A. Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials. Br J Anaesth. 2018;121(2):384–97. https://doi.org/10.1016/j.bja.2018.04.046.

Article  CAS  PubMed  Google Scholar 

Motlagh SD, Rokhtabnak F, Ghodraty MR, Delarestaghi MM, Saadat S, Araghi Z. Effect of different loading doses of dexmedetomidine on controlled hypotension and the incidence of bradycardia during rhinoplasty: a clinical trial. Anesth Pain Med. 2021;11(4):e118857. https://doi.org/10.5812/aapm.118857.

Article  Google Scholar 

Kim H, Kim Y, Bae J, Yoo S, Lim Y-J, Kim J-T. Comparison of remimazolam and dexmedetomidine for intraoperative sedation in patients undergoing lower extremity surgery under spinal anesthesia: a randomized clinical trial. Reg Anesth Pain Med. 2023;49(2):110–6. https://doi.org/10.1136/rapm-2023-104415.

Article  Google Scholar 

Hu Q, Liu X, Wen C, Li D, Lei X. Remimazolam: an updated review of a new sedative and anaesthetic. Drug Des Devel Ther. 2022;16:3957–74. https://doi.org/10.2147/DDDT.S384155.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KM. Remimazolam: pharmacological characteristics and clinical applications in anesthesiology. Anesth Pain Med. 2022;17(1):1–11. https://doi.org/10.17085/apm.21115.

Article  CAS  Google Scholar 

Memtsoudis S, Cozowicz C, Zubizarreta N, Weinstein SM, Liu J, Kim DH, Poultsides L, Berger MM, Mazumdar M, Poeran J. Risk factors for postoperative delirium in patients undergoing lower extremity joint arthroplasty: a retrospective population-based cohort study. Reg Anesth Pain Med. 2019;44(10):934–43. https://doi.org/10.1136/rapm-2019-100700.

Article  Google Scholar 

Marcantonio ER, Juarez G, Goldman L, Mangione CM, Ludwig LE, Lind L, Katz N, Cook EF, Orav EJ, Lee TH. The relationship of postoperative delirium with psychoactive medications. JAMA. 1994;272(19):1518–22.

Article  CAS  PubMed  Google Scholar 

Inouye SK, Leo-Summers L, Zhang Y, Bogardus ST Jr, Leslie DL, Agostini JV. A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. J Am Geriatr Soc. 2005;53(2):312–8. https://doi.org/10.1111/j.1532-5415.2005.53120.x.

Article  PubMed  Google Scholar 

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83. https://doi.org/10.1016/0021-9681(87)90171-8.

Article  CAS  PubMed  Google Scholar 

Yang J-J, Lei L, Qiu D, Chen S, Xing L-K, Zhao J-W, Mao Y-Y, Yang J-J. Effect of remimazolam on postoperative delirium in older adult patients undergoing orthopedic surgery: a prospective randomized controlled clinical trial. Drug Des Devel Ther. 2023;17:143–53. https://doi.org/10.2147/DDDT.S392569.

Article  CAS  PubMed  PubMed Central