Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases

Agere S, Akhtar N, Riegsecker S, Ahmed S (2015) Epigallocatechin-3-gallate (egcg) inhibits rantes/ccl5 induced mmp-1 and mmp-13 expression in human rheumatoid arthritis synovial fibroblasts. Faseb J 29:LB280

Article  Google Scholar 

Ahamad N, Kar A, Mehta S, Dewani M, Ravichandran V, Bhardwaj P, Sharma S, Banerjee R (2021) Immunomodulatory nanosystems for treating inflammatory diseases. Biomaterials 274:120875

Article  CAS  PubMed  Google Scholar 

Ahmed SM, Luo L, Namani A, Wang XJ, Tang X (2017) Nrf2 signaling pathway: pivotal roles in inflammation. BBA-Mol Basis Dis 1863:585–597

Article  CAS  Google Scholar 

Alborzinia H, Ignashkova TI, Dejure FR, Gendarme M, Theobald J, Wolfl S, Lindemann RK, Reiling JH (2018) Golgi stress mediates redox imbalance and ferroptosis in human cells. Communications Biology 1:210

Article  PubMed  PubMed Central  Google Scholar 

Alivernini S, Tolusso B, Ferraccioli G, Gremese E, Kurowska-Stolarska M, McInnes IB (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clin Exp Immunol 193:13–23

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alu A, Han X, Ma X, Wu M, Wei Y, Wei X (2020) The role of lysosome in regulated necrosis. Acta Pharmaceutica Sinica B 10:1880–1903

Article  CAS  PubMed  PubMed Central  Google Scholar 

An Y, Luo Q, Han D, Guan L (2023) Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating nrf2/ho-1 axis. Int Immunopharmacol 118:110029

Article  CAS  PubMed  Google Scholar 

Anandhan A, Dodson M, Schmidlin CJ, Liu P, Zhang DD (2020) Breakdown of an ironclad defense system: the critical role of nrf2 in mediating ferroptosis. Cell Chem Biol 27:436–447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Annie-Mathew AS, Prem-Santhosh S, Jayasuriya R, Ganesh G, Ramkumar KM, Sarada D (2021) The pivotal role of nrf2 activators in adipocyte biology. Pharmacol Res 173:105853

Article  CAS  PubMed  Google Scholar 

Arbiser JL, Bonner MY, Ward N, Elsey J, Rao S (2018) Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer. BBA-Gen Subjects 1862:2518–2527

Article  CAS  Google Scholar 

Ardite E, Sans M, Panes J, Romero FJ, Pique JM, Fernandez-Checa JC (2000) Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Lab Invest 80:735–744

Article  CAS  PubMed  Google Scholar 

Armagan G, Sevgili E, Gürkan FT, Köse FA, Bilgiç T, Dagcı T, Saso L (2019) Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3β in MPP+-Induced Cell Damage. Molecules 24:1377

Article  PubMed  PubMed Central  Google Scholar 

Bai T, Li M, Liu Y, Qiao Z, Wang Z (2020) Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell. Free Radical Biol Med 160:92–102

Article  CAS  Google Scholar 

Baird L, Yamamoto M (2020) The molecular mechanisms regulating the keap1-nrf2 pathway. Mol Cell Biol 40:e00099–20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balihodzic A, Prinz F, Dengler MA, Calin GA, Jost PJ, Pichler M (2022) Non-coding rnas and ferroptosis: potential implications for cancer therapy. Cell Death Differ 29:1094–1106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman SC, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN (2018) Electrophilic properties of itaconate and derivatives regulate the ikappabzeta-atf3 inflammatory axis. Nature 556:501–504

Article  CAS  PubMed  PubMed Central  Google Scholar 

Battino M, Giampieri F, Pistollato F, Sureda A, de Oliveira MR, Pittalà V, Fallarino F, Nabavi SF, Atanasov AG, Nabavi SM (2018) Nrf2 as regulator of innate immunity: a molecular swiss army knife! Biotechnol Adv 36:358–370

Article  CAS  PubMed  Google Scholar 

Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA (2019) The coq oxidoreductase fsp1 acts parallel to gpx4 to inhibit ferroptosis. Nature 575:688–692

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bojanowski K, Ibeji CU, Singh P, Swindell WR, Chaudhuri RK (2021) A sensitization-free dimethyl fumarate prodrug, isosorbide di-(methyl fumarate), provides a topical treatment candidate for psoriasis. Jid Innov 1:100040

Article  PubMed  PubMed Central  Google Scholar 

Brown RH, Reynolds C, Brooker A, Talalay P, Fahey JW (2015) Sulforaphane improves the bronchoprotective response in asthmatics through nrf2-mediated gene pathways. Respir Res 16:106

Article  PubMed  PubMed Central  Google Scholar 

Brown P, Pratt AG, Hyrich KL (2024) Therapeutic advances in rheumatoid arthritis. Bmj-British Medical Journal 384:e70856

Google Scholar 

Cai Y, Kurita-Ochiai T, Hashizume T, Yamamoto M (2013) Green tea epigallocatechin-3-gallate attenuates porphyromonas gingivalis-induced atherosclerosis. Pathogens Dis 67:76–83

Article  CAS  Google Scholar 

Campbell MR, Karaca M, Adamski KN, Chorley BN, Wang X, Bell DA (2013) Novel hematopoietic target genes in the nrf2-mediated transcriptional pathway. Oxid Med Cell Longev 2013:120305

Article  PubMed  PubMed Central  Google Scholar 

Canning P, Bullock AN (2014) New strategies to inhibit keap1 and the cul3-based e3 ubiquitin ligases. Biochem Soc Trans 42:103–107

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canning P, Sorrell FJ, Bullock AN (2015) Structural basis of keap1 interactions with nrf2. Free Radical Biol Med 88:101–107

Article  CAS  Google Scholar 

Cepelak I, Dodig S, Dodig DC (2020) Ferroptosis: regulated cell death. Arhiv Za Higijenu Rada I Toksikologiju-Arch Ind Hygiene Toxicol 71:99–109

CAS  Google Scholar 

Changlin Z, Ying Z, Shuhua Z, Zeng J, Chi H (2021) Research on the protective effect of mir-185-3p mediated by huangqin-tang decoction (hqt) on the epithelial barrier function of ulcerative colitis. Evid-Based Complement Altern Med 2021:4775606

Article  Google Scholar 

Chen X, Cubillos-Ruiz JR (2021) Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer 21:71–88

Article  CAS  PubMed  Google Scholar 

Chen QM, Maltagliati AJ (2018) Nrf2 at the heart of oxidative stress and cardiac protection. Physiol Genomics 50:77–97

Article  CAS  PubMed  Google Scholar 

Chen H, Lu C, Liu H, Wang M, Zhao H, Yan Y, Han L (2017) Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the nf-kappab pathway. Int Immunopharmacol 48:110–117

Article  CAS  PubMed  Google Scholar 

Chen Y, Zhang P, Chen W, Chen G (2020) Ferroptosis mediated dss-induced ulcerative colitis associated with nrf2/ho-1 signaling pathway. Immunol Lett 225:9–15

Article  CAS  PubMed  Google Scholar 

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