Alboni S, Cervia D, Sugama S, Conti B (2010) Interleukin 18 in the CNS. J Neuroinflammation 7:9

Article  PubMed  PubMed Central  Google Scholar 

Alsahebfosoul F, Jahanbani-Ardakani H, Ghavimi R, Sedaghat N, Etemadifar M (2018) Serum level of interleukin 36 in patients with multiple sclerosis. J Immunoass Immunochem 39(5):558–564

Article  CAS  Google Scholar 

An Y, Q Chen, N Quan (2011) "Interleukin-1exerts distinct actions on different cell types of the brain in vitro." Journal inflammation research 11–20

Andreyev AY, Kushnareva YE, Starkov AA (2005) Mitochondrial metabolism of reactive oxygen species. Biochem Mosc 70(2):200–214

Article  CAS  Google Scholar 

Bellenguez C, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, N Amin, AC Naj, R Campos-Martin, B Grenier-Boley, V Andrade, PA Holmans, A Boland, V Damotte, SJD van Lee, MR Costa, T Kuulasmaa, Q Yang, I de Rojas, JC Bis, A Yaqub, I Prokic, J Chapuis, S Ahmad, V Giedraitis, D Aarsland, P Garcia-Gonzalez, C Abdelnour, E Alarcón-Martín, D Alcolea, M Alegret, I Alvarez, V Álvarez, NJ Armstrong, A Tsolaki, C Antúnez, I Appollonio, M Arcaro, S Archetti, AA Pastor, B Arosio, L Athanasiu, H Bailly, N Banaj, M Baquero, S Barral, A Beiser, AB Pastor, JE Below, P Benchek, L Benussi, C Berr, C Besse, V Bessi, G Binetti, A Bizarro, R Blesa, M Boada, E Boerwinkle, B Borroni, S Boschi, P Bossù, G Bråthen, J Bressler, C Bresner, H Brodaty, KJ Brookes, LI Brusco, D Buiza-Rueda, K Bûrger, V. Burholt, WS Bush, M Calero, LB Cantwell, G Chene, J Chung, ML Cuccaro, Á Carracedo, R Cecchetti, L Cervera-Carles, C Charbonnier, HH Chen, C Chillotti, S Ciccone, J Claassen, C Clark, E Conti, A Corma-Gómez, E Costantini, C Custodero, D Daian, MC Dalmasso, A Daniele, E Dardiotis, JF Dartigues, PP de Deyn, KP de Lopes, LD de Witte, S Debette, J Deckert, T Del Ser, N Denning, A DeStefano, M Dichgans, J Diehl-Schmid, M Diez-Fairen, PD Rossi, S Djurovic, E Duron, E Düzel, C Dufouil, G Eiriksdottir, S Engelborghs, V Escott-Price, A Espinosa, M Ewers, KM Faber, T Fabrizio, SF Nielsen, DW Fardo, L Farotti, C Fenoglio, M Fernández-Fuertes, R Ferrari, CB Ferreira, E Ferri, B Fin, P Fischer, T Fladby, K Fließbach, B Fongang, M Fornage, J Fortea, TM Foroud, S Fostinelli, NC. Fox, E Franco-Macías, MJ Bullido, A Frank-García, L Froelich, B Fulton-Howard, D Galimberti, JM García-Alberca, P García-González, S Garcia-Madrona, G Garcia-Ribas, R Ghidoni, I Giegling, G Giorgio, AM Goate, O Goldhardt, D Gomez-Fonseca, A González-Pérez, C Graff, G Grande, E Green, T Grimmer, E Grünblatt, M Grunin, V Gudnason, T Guetta-Baranes, A Haapasalo, G Hadjigeorgiou, JL Haines, KL Hamilton-Nelson, H Hampel, O Hanon, J Hardy, AM Hartmann, L Hausner, J Harwood, S Heilmann-Heimbach, S Helisalmi, MT Heneka, I Hernández, MJ Herrmann, P Hoffmann, C Holmes, H Holstege, RH Vilas, M Hulsman, J Humphrey, GJ Biessels, X Jian, C Johansson, GR Jun, Y Kastumata, J Kauwe, PG Kehoe, L Kilander, AK Ståhlbom, M Kivipelto, A Koivisto, J Kornhuber, MH Kosmidis, WA Kukull, PP Kuksa, BW Kunkle, AB Kuzma, C Lage, EJ Laukka, L Launer, A Lauria, CY Lee, J Lehtisalo, O Lerch, A Lleó, W Longstreth, J R, O Lopez, AL de Munain, S Love, M Löwemark, L Luckcuck, KL Lunetta, Y Ma, J Macías, CA MacLeod, W Maier, F Mangialasche, M Spallazzi, M Marquié, R Marshall, ER Martin, AM Montes, CM Rodríguez, C Masullo, R Mayeux, S Mead, P Mecocci, M Medina, A Meggy, S Mehrabian, S Mendoza, M Menéndez-González, P Mir, S Moebus, M Mol, L Molina-Porcel, L Montrreal, L Morelli, F Moreno, K Morgan, T Mosley, MM Nöthen, C Muchnik, S Mukherjee, B Nacmias, T Ngandu, G Nicolas, BG Nordestgaard, R Olaso, A Orellana, M Orsini, G Ortega, A Padovani, C Paolo, G Papenberg, L Parnetti, F Pasquier, P Pastor, G Peloso, A Pérez-Cordón, J Pérez-Tur, P Pericard, O Peters, YAL Pijnenburg, JA Pineda, G Piñol-Ripoll, C Pisanu, T Polak, J Popp, D Posthuma, J Priller, R Puerta, O Quenez, I Quintela, JQ Thomassen, A Rábano, I Rainero, F Rajabli, I Ramakers, LM Real, MJT Reinders, C Reitz, D Reyes-Dumeyer, P Ridge, S Riedel-Heller, P Riederer, N Roberto, E Rodriguez-Rodriguez, A Rongve, IR Allende, M Rosende-Roca, JL Royo, E Rubino, D Rujescu, ME Sáez, P Sakka, I Saltvedt, Á Sanabria, MB Sánchez-Arjona, F Sanchez-Garcia, PS Juan, R Sánchez-Valle, SB Sando, C Sarnowski, CL Satizabal, M Scamosci, N Scarmeas, E Scarpini, P Scheltens, N Scherbaum, M Scherer, M Schmid, A Schneider, JM Schott, G Selbæk, D Seripa, M Serrano, J Sha, AA Shadrin, O Skrobot, S Slifer, GJL Snijders, H Soininen, V Solfrizzi, A Solomon, Y Song, S Sorbi, O Sotolongo-Grau, G Spalletta, A Spottke, A Squassina, E Stordal, JP Tartan, L Tárraga, N Tesí, A Thalamuthu, T Thomas, G Tosto, L Traykov, L Tremolizzo, A Tybjærg-Hansen, A Uitterlinden, A Ullgren, I Ulstein, S Valero, O Valladares, CV Broeckhoven, J Vance, BN Vardarajan, AD van Lugt, JV Dongen, J van Rooij, J van Swieten, R Vandenberghe, F Verhey, JS Vidal, J Vogelgsang, M Vyhnalek, M Wagner, D Wallon, LS Wang, R Wang, L Weinhold, J Wiltfang, G Windle, B Woods, M Yannakoulia, H Zare, Y Zhao, X Zhang, C Zhu, M Zulaica, LA Farrer, BM Psaty, M Ghanbari, T Raj, P Sachdev, K Mather, F Jessen, MA Ikram, A de Mendonça, J Hort, M Tsolaki, MA Pericak-Vance, P Amouyel, J Williams, R Frikke-Schmidt, J Clarimon, JF Deleuze, G Rossi, S Seshadri, OA Andreassen, M Ingelsson, M Hiltunen, K Sleegers, GD Schellenberg, CM van Duijn, R Sims, WM van der Flier, A Ruiz, A Ramirez, JC Lambert (2022) New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet 54 4 412–436

Bossù P, Ciaramella A, Moro ML, Bellincampi L, Bernardini S, Federici G, Trequattrini A, Macciardi F, Spoletini I, Di Iulio F, Caltagirone C, Spalletta G (2007) Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer’s disease. J Neurol Neurosurg Psychiatry 78(8):807–811

Article  PubMed  PubMed Central  Google Scholar 

Bossù P, Ciaramella A, Salani F, Vanni D, Palladino I, Caltagirone C, Scapigliati G (2010) Interleukin-18, from neuroinflammation to Alzheimer’s disease. Curr Pharm Des 16(38):4213–4224

Article  PubMed  Google Scholar 

Bossu P, Ciaramella A, Salani F, Bizzoni F, Varsi E, Di Iulio F, Giubilei F, Gianni W, Trequattrini A, Moro ML (2008) Interleukin-18 produced by peripheral blood cells is increased in Alzheimer’s disease and correlates with cognitive impairment. Brain Behav Immun 22(4):487–492

Article  PubMed  CAS  Google Scholar 

Brosseron F, Krauthausen M, Kummer M, Heneka MT (2014) Body fluid cytokine levels in mild cognitive impairment and Alzheimer’s disease: a comparative overview. Mol Neurobiol 50(2):534–544

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cacabelos R (2020) How plausible is an Alzheimer’s disease vaccine? Expert Opin Drug Discov 15(1):1–6

Article  PubMed  CAS  Google Scholar 

Cai Y, Liu J, Wang B, Sun M, Yang H (2022) Microglia in the neuroinflammatory pathogenesis of Alzheimer’s disease and related therapeutic targets. Front Immunol 13:856376

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cao W, Kim JH, Reber AJ, Hoelscher M, Belser JA, Lu X, Katz JM, Gangappa S, Plante M, Burt DS, Sambhara S (2017) Nasal delivery of protollin-adjuvanted H5N1 vaccine induces enhanced systemic as well as mucosal immunity in mice. Vaccine 35(25):3318–3325

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carlock C, Wu J, Shim J, Moreno-Gonzalez I, Pitcher MR, Hicks J, Suzuki A, Iwata J, Quevado J, Lou Y (2017) Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice. Transl Psychiatry 7(7):e1164

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cavalli G, Dinarello CA (2018) Suppression of inflammation and acquired immunity by IL-37. Immunol Rev 281(1):179–190

Article  PubMed  CAS  Google Scholar 

Chan AH, Schroder K (2019) Inflammasome signaling and regulation of interleukin-1 family cytokines. J Exp Med 217(1):e20190314

Article  PubMed Central  Google Scholar 

Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC (2009) Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease. Mol Psychiatry 14(11):1004–1016

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen JX, Yan SS (2010) Role of mitochondrial amyloid-beta in Alzheimer’s disease. J Alzheimers Dis 20(Suppl 2):S569-578

Article  PubMed  Google Scholar 

Chen G-F, Xu T-H, Yan Y, Zhou Y-R, Jiang Y, Melcher K, Xu HE (2017) Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin 38(9):1205–1235

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng ZY, Xia QP, Hu YH, Wang C, He L (2020) Dopamine D1 receptor agonist A-68930 ameliorates Aβ(1–42)-induced cognitive impairment and neuroinflammation in mice. Int Immunopharmacol 88:106963

Article  PubMed  CAS  Google Scholar 

Craft JM, Watterson DM, Hirsch E, Van Eldik LJ (2005) Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid. J Neuroinflammation 2:1–9

Article  Google Scholar 

Crews L, Masliah E (2010) Molecular mechanisms of neurodegeneration in Alzheimer’s disease. Hum Mol Genet 19(R1):R12-20

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cummings JL, Cohen S, van Dyck CH, Brody M, Curtis C, Cho W, Ward M, Friesenhahn M, Rabe C, Brunstein F, Quartino A, Honigberg LA, Fuji RN, Clayton D, Mortensen D, Ho C, Paul R (2018) ABBY: a phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease. Neurology 90(21):e1889–e1897

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dinarello CA (1999) Cytokines as endogenous pyrogens. J Infect Dis 179(Suppl 2):S294-304

Article  PubMed  CAS  Google Scholar 

Dinarello CA (2013) Overview of the interleukin-1 family of ligands and receptors. Semin Immunol 25(6):389–393

Article  PubMed  CAS  Google Scholar 

Dinarello CA (2018) Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev 281(1):8–27

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O’Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A, Kelk P, van de Veerdonk F, Gabel C (2010) IL-1 family nomenclature. Nat Immunol 11(11):973

Article  PubMed  PubMed Central  CAS  Google Scholar 

Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R (2014) Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease. N Engl J Med 370(4):311–321

Article  PubMed  CAS  Google Scholar 

Ennerfelt HE, Lukens JR (2020) The role of innate immunity in Alzheimer’s disease. Immunol Rev 297(1):225–246

Article  PubMed  PubMed Central  CAS  Google Scholar 

Facci L, Barbierato M, Zusso M, Skaper SD, Giusti P (2018) Serum amyloid a primes microglia for ATP-dependent interleukin-1β release. J Neuroinflammation 15(1):164

Article  PubMed