Bone Fragility in Diabetes and its Management: A Narrative Review

Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, Pavkov ME, Ramachandaran A, Wild SH, James S, Herman WH, Zhang P, Bommer C, Kuo S, Boyko EJ, Magliano DJ. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022 Jan;183:109119. https://doi.org/10.1016/j.diabres.2021.109119. Epub 2021 Dec 6. Erratum in: Diabetes Res Clin Pract. 2023 Oct;204:110945. PMID: 34879977.

Bommer C, Heesemann E, Sagalova V, Manne-Goehler J, Atun R, Bärnighausen T, Vollmer S. The global economic burden of diabetes in adults aged 20–79 years: a cost-of-illness study. Lancet Diabetes Endocrinol. 2017;5(6):423–30. https://doi.org/10.1016/S2213-8587(17)30097-9. (Epub 2017 Apr 26 PMID: 28456416).

Article  PubMed  Google Scholar 

Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2(6):285–9. https://doi.org/10.1007/BF01623184. (PMID: 1421796).

Article  CAS  PubMed  Google Scholar 

Gullberg B, Johnell O, Kanis JA. World-wide projections for hip fracture. Osteoporos Int. 1997;7(5):407–13. https://doi.org/10.1007/pl00004148. (PMID: 9425497).

Article  CAS  PubMed  Google Scholar 

Lewiecki EM, Ortendahl JD, Vanderpuye-Orgle J, Grauer A, Arellano J, Lemay J, Harmon AL, Broder MS, Singer AJ. Healthcare policy changes in osteoporosis can improve outcomes and reduce costs in the United States. JBMR Plus. 2019;3(9): e10192. https://doi.org/10.1002/jbm4.10192.PMID:31667450;PMCID:PMC6808223.

Article  PubMed  PubMed Central  Google Scholar 

Chandran M, Lau TC, Gagnon-Arpin I, Dobrescu A, Li W, Leung MYM, Patil N, Zhao Z. The health and economic burden of osteoporotic fractures in Singapore and the potential impact of increasing treatment rates through more pharmacological options. Arch Osteoporos. 2019;14(1):114. https://doi.org/10.1007/s11657-019-0664-4. (PMID: 31773442).

Article  PubMed  Google Scholar 

Haentjens P, Magaziner J, Colón-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S. Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med. 2010;152(6):380–90. https://doi.org/10.7326/0003-4819-152-6-201003160-00008.PMID:20231569;PMCID:PMC3010729.

Article  PubMed  PubMed Central  Google Scholar 

Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury. 2012;43(6):676–85. https://doi.org/10.1016/j.injury.2011.05.017. (Epub 2011 Jun 17 PMID: 21683355).

Article  PubMed  Google Scholar 

Vokó Z, Gáspár K, Inotai A, Horváth C, Bors K, Speer G, Kaló Z. Osteoporotic fractures may impair life as much as the complications of diabetes. J Eval Clin Pract. 2017;23(6):1375–80. https://doi.org/10.1111/jep.12800. (Epub 2017 Sep 12 PMID: 28895276).

Article  PubMed  Google Scholar 

Chandran M, Aftab N, Amin A, Amphansap T, Bhadada SK, Chadha M, Chan DC, Hew FL, Kaur S, Khan AH, Kwee AK, Ho-Pham LT, Lekamwasam S, Minh DC, Prasanth A, Sharma R, Valleenukul T, Zehra N, Mithal A. Evaluating compliance with the care standard of proactively assessing bone health in patients with diabetes: a pilot audit of practice across Asia by the Asia Pacific Consortium on Osteoporosis (APCO). Arch Osteoporos. 2024;19(1):48. https://doi.org/10.1007/s11657-024-01399-y.PMID:38862849;PMCID:PMC11166814.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandran M, Bhadada SK, Ebeling PR, Gilchrist NL, Khan AH, Halbout P, Lekamwasam S, Lyubomirsky G, Mitchell PJ, Nguyen TV, Tiu KL; Asia Pacific Consortium on Osteoporosis. IQ driving QI: the Asia Pacific Consortium on Osteoporosis (APCO): an innovative and collaborative initiative to improve osteoporosis care in the Asia Pacific. Osteoporos Int. 2020 Nov;31(11):2077-2081. https://doi.org/10.1007/s00198-020-05495-w. Epub 2020 Jun 19. PMID: 32561953; PMCID: PMC7560927.

Rasmussen NH, Dal J, den Bergh JV, de Vries F, Jensen MH, Vestergaard P. Increased risk of falls, fall-related injuries and fractures in people with type 1 and type 2 diabetes - a nationwide cohort study. Curr Drug Saf. 2021;16(1):52–61. https://doi.org/10.2174/1574886315666200908110058. (PMID: 32900349).

Article  CAS  PubMed  Google Scholar 

Rasmussen NH, Dal J, Jensen MH, Kvist AV, van den Bergh J, Hirata RP, Vestergaard P. Impaired postural control in diabetes-a predictor of falls? Arch Osteoporos. 2022;18(1):6. https://doi.org/10.1007/s11657-022-01188-5. (PMID: 36482222).

Article  PubMed  Google Scholar 

Hasserius R, Karlsson MK, Jónsson B, Redlund-Johnell I, Johnell O. Long-term morbidity and mortality after a clinically diagnosed vertebral fracture in the elderly–a 12- and 22-year follow-up of 257 patients. Calcified Tissue Int. 2005;76(4):235–42. https://doi.org/10.1007/s00223-004-2222-2. (PMID: 15812579).

Article  CAS  Google Scholar 

Panula J, Pihlajamäki H, Mattila VM, Jaatinen P, Vahlberg T, Aarnio P, Kivelä SL. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011;20(12):105. https://doi.org/10.1186/1471-2474-12-105.PMID:21599967;PMCID:PMC3118151.

Article  Google Scholar 

Takamoto I, Kadowaki T. Diabetes and osteoporosis. Clin Calcium. 2004;14(2):255–61.

CAS  PubMed  Google Scholar 

Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F. Secondary osteoporosis. Endocr Rev. 2022;43(2):240–313. https://doi.org/10.1210/endrev/bnab028.

Article  PubMed  Google Scholar 

Wukich DK, Joseph A, Ryan M, Ramirez C, Irrgang JJ. Outcomes of ankle fractures in patients with uncomplicated versus complicated diabetes. Foot Ankle Int. 2011;32(2):120–30. https://doi.org/10.3113/FAI.2011.0120. (PMID: 21288410).

Article  PubMed  Google Scholar 

Humphers JM, Shibuya N, Fluhman BL, Jupiter D. The impact of glycosylated hemoglobin and diabetes mellitus on wound-healing complications and infection after foot and ankle surgery. J Am Podiatr Med Assoc. 2014;104(4):320–9. https://doi.org/10.7547/0003-0538-104.4.320. (PMID: 25076074).

Article  PubMed  Google Scholar 

Nirantharakumar K, Toulis KA, Wijesinghe H, Mastan MS, Srikantharajah M, Bhatta S, Marshall T, Coleman JJ. Impact of diabetes on inpatient mortality and length of stay for elderly patients presenting with fracture of the proximal femur. J Diabetes Complications. 2013 May-Jun;27(3):208-10. https://doi.org/10.1016/j.jdiacomp.2012.11.010. Epub 2013 Jan 9. PMID: 23312217.

Norris R, Parker M. Diabetes mellitus and hip fracture: a study of 5966 cases. Injury. 2011;42(11):1313–6. https://doi.org/10.1016/j.injury.2011.03.021. (Epub 2011 Apr 13 PMID: 21489532).

Article  PubMed  Google Scholar 

Chandran M, Mitchell PJ, Amphansap T, Bhadada SK, Chadha M, Chan DC, Chung YS, Ebeling P, Gilchrist N, Habib Khan A, Halbout P, Hew FL, Lan HT, Lau TC, Lee JK, Lekamwasam S, Lyubomirsky G, Mercado-Asis LB, Mithal A, Nguyen TV, Pandey D, Reid IR, Suzuki A, Chit TT, Tiu KL, Valleenukul T, Yung CK, Zhao YL; Asia Pacific Consortium on Osteoporosis (APCO). Development of the Asia Pacific Consortium on Osteoporosis (APCO) Framework: clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region. Osteoporos Int. 2021 Jul;32(7):1249-1275. https://doi.org/10.1007/s00198-020-05742-0. Epub 2021 Jan 27. Erratum in: Osteoporos Int. 2021 Jul;32(7):1277-1278. https://doi.org/10.1007/s00198-021-05953-z. PMID: 33502559; PMCID: PMC8192320.

https://diabetes.org/health-wellness/fitness/balance-and-avoiding-falls#:~:text=Risk%20factors%20for%20falls%3A,consume%20rapid%2Dacting%20carbohydrates%20immediately.

American Diabetes Association Professional Practice Committee; 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes—2024. Diabetes Care 1 January 2024; 47 (Supplement_1): S52–S76. https://doi.org/10.2337/dc24-S004.

Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB. Incidence and mortality of hip fractures in the United States. JAMA. 2009;302(14):1573–9. https://doi.org/10.1001/jama.2009.1462.PMID:19826027;PMCID:PMC4410861.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abrahamsen B, Skjødt MK, Vestergaard P. Hip fracture rates and time trends in use of anti-osteoporosis medications in Denmark for the period 2005 to 2015: missed opportunities in fracture prevention. Bone. 2019;120:476–81. https://doi.org/10.1016/j.bone.2018.12.016. (Epub 2018 Dec 21 PMID: 30583122).

Article  PubMed  Google Scholar 

Abtahi S, Driessen JHM, Vestergaard P, van den Bergh J, Boonen A, de Vries F, Burden AM. Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010. Osteoporos Int. 2019 Nov;30(11):2217-2223. https://doi.org/10.1007/s00198-019-05109-0. Epub 2019 Aug 15. PMID: 31418061; PMCID: PMC6811370.

Nasser MI, Kvist AV, Vestergaard P, Eastell R, Burden AM, Frost M. Sex- and age group-specific fracture incidence rates trends for type 1 and 2 diabetes mellitus. JBMR Plus. 2023;7(11): e10836. https://doi.org/10.1002/jbm4.10836.PMID:38025040;PMCID:PMC10652176.

Article  PubMed  PubMed Central  Google Scholar 

Kvist AV, Nasser MI, Vestergaard P, Frost M, Burden AM. Site-specific fracture incidence rates among patients with type 1 diabetes, type 2 diabetes, or without diabetes in Denmark (1997–2017). Diabetes Care. 2023;46(3):633–42. https://doi.org/10.2337/dc22-1004.PMID:36696428;PMCID:PMC10020021.

Article  PubMed  PubMed Central  Google Scholar 

Janghorbani M, Van Dam RM,Willett WC, Hu FB. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 2007;166: 495e505.

Janghorbani M, Feskanich D, Willett WC, et al. Prospective study of diabetes mellitus and risk of hip fracture: the Nurses’ Health Study. Diabetes Care. 2006;29:1573–8.

Article  PubMed  Google Scholar 

Bai J, Gao Q, Wang C, et al. Diabetes mellitus and risk of low-energy fracture: a meta-analysis. Aging Clin Exp Res. 2020;32:2173–86. https://doi.org/10.1007/s40520-019-01417-x.

Article  PubMed  Google Scholar 

Sheu A, Bliuc D, Tran T, White CP, Center JR. Fractures in type 2 diabetes confer excess mortality: the dubbo osteoporosis epidemiology study. Bone. 2022;159: 116373. https://doi.org/10.1016/j.bone.2022.116373.

Article  PubMed  Google Scholar 

Ross

留言 (0)

沒有登入
gif