Dynamics of clonal hematopoiesis and risk of hematologic malignancy

Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, et al. The repertoire of mutational signatures in human cancer. Nature. 2020;578(7793):94–101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martincorena I, Campbell PJ. Somatic mutation in cancer and normal cells. Science. 2015;349(6255):1483–9.

Article  CAS  PubMed  Google Scholar 

Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Genovese G, Kahler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014;371(26):2477–87.

Article  PubMed  PubMed Central  Google Scholar 

Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371(26):2488–98.

Article  PubMed  PubMed Central  Google Scholar 

Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med. 2014;20(12):1472–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, et al. Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N Engl J Med. 2017;377(2):111–21.

Article  PubMed  PubMed Central  Google Scholar 

Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, et al. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017;355(6327):842–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, et al. Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023;616(7958):747–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, et al. Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Blood. 2022;139(3):357–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agrawal M, Niroula A, Cunin P, McConkey M, Shkolnik V, Kim PG, et al. TET2-mutant clonal hematopoiesis and risk of gout. Blood. 2022;140(10):1094–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kessler MD, Damask A, O’Keeffe S, Banerjee N, Li D, Watanabe K, et al. Common and rare variant associations with clonal haematopoiesis phenotypes. Nature. 2022;612(7939):301–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian R, Wiley B, Liu J, Zong X, Truong B, Zhao S, et al. Clonal hematopoiesis and risk of incident lung cancer. J Clin Oncol. 2023;41(7):1423–33.

Article  CAS  PubMed  Google Scholar 

Abplanalp WT, Cremer S, John D, Hoffmann J, Schuhmacher B, Merten M, et al. Clonal hematopoiesis-driver DNMT3A mutations alter immune cells in heart failure. Circ Res. 2021;128(2):216–28.

Article  CAS  PubMed  Google Scholar 

Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, et al. Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1beta/NLRP3 inflammasome. J Am Coll Cardiol. 2018;71(8):875–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Sano S, Yura Y, Ke Z, Sano M, Oshima K, et al. Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. JCI Insight. 2020. https://doi.org/10.1172/jci.insight.135204.

Article  PubMed  PubMed Central  Google Scholar 

Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, et al. Clonal hematopoiesis is associated with protection from Alzheimer’s disease. Nat Med. 2023;29(7):1662–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weeks LD, Marinac CR, Redd R, Abel G, Lin A, Agrawal M, et al. Age-related diseases of inflammation in myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood. 2022;139(8):1246–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arends CM, Galan-Sousa J, Hoyer K, Chan W, Jager M, Yoshida K, et al. Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis. Leukemia. 2018. https://doi.org/10.1038/s41375-018-0047-7.

Article  PubMed  Google Scholar 

Buscarlet M, Provost S, Zada YF, Bourgoin V, Mollica L, Dube MP, et al. Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A. Blood. 2018;132(3):277–80.

Article  CAS  PubMed  Google Scholar 

Desai P, Mencia-Trinchant N, Savenkov O, Simon MS, Cheang G, Lee S, et al. Somatic mutations precede acute myeloid leukemia years before diagnosis. Nat Med. 2018;24(7):1015–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, et al. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature. 2018;559(7714):400–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arends CM, Liman TG, Strzelecka PM, Kufner A, Lowe P, Huo S, et al. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke. Blood. 2023;141(7):787–99.

Article  CAS  PubMed  Google Scholar 

Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020;586(7831):763–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watson CJ, Papula AL, Poon GYP, Wong WH, Young AL, Druley TE, et al. The evolutionary dynamics and fitness landscape of clonal hematopoiesis. Science. 2020;367(6485):1449–54.

Article  CAS  PubMed  Google Scholar 

Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, et al. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Nature. 2023;616(7958):755–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitchell E, Spencer Chapman M, Williams N, Dawson KJ, Mende N, Calderbank EF, et al. Clonal dynamics of haematopoiesis across the human lifespan. Nature. 2022;606(7913):343–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, et al. Clock-like mutational processes in human somatic cells. Nat Genet. 2015;47(12):1402–7.

Article  CAS 

留言 (0)

沒有登入
gif