Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstrom-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373–498.

Article  PubMed  Google Scholar 

Navar AM, Kolkailah AA, Overton R, Shah NP, Rousseau JF, Flaker GC, et al. Trends in oral anticoagulant use among 436 864 Patients with atrial fibrillation in community practice, 2011 to 2020. J Am Heart Assoc. 2022;11(22):e026723.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e1–156.

Article  PubMed  Google Scholar 

Freeman JV, Varosy P, Price MJ, Slotwiner D, Kusumoto FM, Rammohan C, et al. The NCDR Left atrial appendage occlusion registry. J Am Coll Cardiol. 2020;75(13):1503–18.

Article  PubMed  PubMed Central  Google Scholar 

Kar S, Doshi SK, Sadhu A, Horton R, Osorio J, Ellis C, et al. Primary outcome evaluation of a next-generation left atrial appendage closure device: Results from the PINNACLE FLX Trial. Circulation. 2021;143(18):1754–62.

Article  CAS  PubMed  Google Scholar 

Lakkireddy D, Thaler D, Ellis CR, Swarup V, Sondergaard L, Carroll J, et al. Amplatzer amulet left atrial appendage occluder versus watchman device for stroke prophylaxis (Amulet IDE): A randomized. Control Trial Circ. 2021;144(19):1543–52.

Google Scholar 

Galea R, De Marco F, Meneveau N, Aminian A, Anselme F, Grani C, et al. Amulet or watchman device for percutaneous left atrial appendage closure: Primary results of the SWISS-APERO randomized clinical trial. Circulation. 2022;145(10):724–38.

Article  PubMed  Google Scholar 

Whitlock RP, Belley-Cote EP, Paparella D, Healey JS, Brady K, Sharma M, et al. Left atrial appendage occlusion during cardiac surgery to prevent stroke. N Engl J Med. 2021;384(22):2081–91.

Article  PubMed  Google Scholar 

Holmes DR, Reddy VY, Turi ZG, Doshi SK, Sievert H, Buchbinder M, et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: A randomised non-inferiority trial. Lancet. 2009;374(9689):534–42.

Article  CAS  PubMed  Google Scholar 

Reddy VY, Doshi SK, Kar S, Gibson DN, Price MJ, Huber K, et al. 5-year outcomes after left atrial appendage closure: From the PREVAIL and PROTECT AF Trials. J Am Coll Cardiol. 2017;70(24):2964–75.

Article  PubMed  Google Scholar 

January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: A report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart rhythm society. J Am Coll Cardiol. 2019;74(1):104–32.

Article  PubMed  Google Scholar 

Osmancik P, Herman D, Neuzil P, Hala P, Taborsky M, Kala P, et al. Left atrial appendage closure versus direct oral anticoagulants in high-risk patients with atrial fibrillation. J Am Coll Cardiol. 2020;75(25):3122–35.

Article  CAS  PubMed  Google Scholar 

Reddy VY, Mobius-Winkler S, Miller MA, Neuzil P, Schuler G, Wiebe J, et al. Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: The ASAP study (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology). J Am Coll Cardiol. 2013;61(25):2551–6.

Article  PubMed  Google Scholar 

Holmes DR, Reddy VY, Buchbinder M, Stein K, Elletson M, Bergmann MW, et al. The assessment of the watchman device in patients unsuitable for oral anticoagulation (ASAP-TOO) trial. Am Heart J. 2017;189:68–74.

Article  PubMed  Google Scholar 

Holmes DR Jr, Korsholm K, Rodes-Cabau J, Saw J, Berti S, Alkhouli MA. Left atrial appendage occlusion. EuroIntervention. 2023;18(13):e1038–65.

Article  PubMed  PubMed Central  Google Scholar 

SR K, Editor real-world experience with WATCHMAN FLX: Outcomes at one-year from surpass. Cardiovascular research technologies 2023; 2023 February 27, 2023; Washington, DC.

Alkhouli M, Alarouri H, Kramer A, Korsholm K, Collins J, De Backer O, et al. Device-related thrombus after left atrial appendage occlusion: Clinical impact, predictors, classification, and management. JACC Cardiovasc Interv. 2023;16(22):2695–707.

Article  PubMed  Google Scholar 

Dukkipati SR, Kar S, Holmes DR, Doshi SK, Swarup V, Gibson DN, et al. Device-related thrombus after left atrial appendage closure: Incidence, predictors, and outcomes. Circulation. 2018;138(9):874–85.

Article  PubMed  Google Scholar 

Alkhouli M, Busu T, Shah K, Osman M, Alqahtani F, Raybuck B. Incidence and clinical impact of device-related thrombus following percutaneous left atrial appendage occlusion: A meta-analysis. JACC Clin Electrophysiol. 2018;4(12):1629–37.

Article  PubMed  Google Scholar 

Fauchier L, Cinaud A, Brigadeau F, Lepillier A, Pierre B, Abbey S, et al. Device-related thrombosis after percutaneous left atrial appendage occlusion for atrial fibrillation. J Am Coll Cardiol. 2018;71(14):1528–36.

Article  PubMed  Google Scholar 

Teiger E, Eschalier R, Amabile N, Rioufol G, Ducrocq G, Garot P, et al. Left atrial appendage closure in very elderly patients in the French National Registry. Heart. 2024;110(4):245–53.

Article  PubMed  Google Scholar 

Cruz-Gonzalez I, Ince H, Kische S, Schmitz T, Schmidt B, Gori T, et al. Left atrial appendage occlusion in patients older than 85 years. Safety and efficacy in the EWOLUTION registry. Rev Esp Cardiol (Engl Ed). 2020;73(1):21–7.

PubMed  Google Scholar 

Sanjoy SS, Choi YH, Sparrow RT, Jneid H, Dawn Abbott J, Nombela-Franco L, et al. Outcomes of elderly patients undergoing left atrial appendage closure. J Am Heart Assoc. 2021;10(19):e021973.

Article  PubMed  PubMed Central  Google Scholar 

Schmidt B, Nielsen-Kudsk JE, Ellis CR, Thaler D, Sabir SA, Gambhir A, et al. Incidence, Predictors, and clinical outcomes of device-related thrombus in the amulet IDE Trial. JACC Clin Electrophysiol. 2023;9(1):96–107.

Article  PubMed  Google Scholar 

Sulaiman S, Roy K, Wang H, de Backer O, Alloco D, Reddy VY, et al. Left atrial appendage occlusion in the elderly: Insights from PROTECT-AF, PREVAIL, and continuous access registries. JACC Clin Electrophysiol. 2023;9(5):669–76.

Article  PubMed  Google Scholar