Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, et al. Gemcitabine and Cisplatin Induction Chemotherapy in nasopharyngeal carcinoma. N Engl J Med. 2019;381(12):1124–35.

Article  CAS  PubMed  Google Scholar 

Olbromski PJ, Bogacz A, Bukowska M, Kamiński A, Moszyński R, Pawlik P, et al. Analysis of the polymorphisms and expression levels of the BCL2, BAX and c-MYC genes in patients with ovarian Cancer. Int J Mol Sci. 2023;24(22):null.

Article  Google Scholar 

Li X, Du Y, Wang Y. The value of LncRNA SNHG5 as a marker for the diagnosis and prognosis of gastric cancer. Am J Translational Res. 2021;13(5):5420–7.

CAS  Google Scholar 

Zong S, Dai W, Guo X, Wang K. LncRNA-SNHG1 promotes macrophage M2-like polarization and contributes to breast cancer growth and metastasis. Aging. 2021;13(19):23169–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang H, Pan Y, Zhang J, Jin L, Zhang X. LncRNA FOXD3-AS1 Promotes the Malignant Progression of Nasopharyngeal Carcinoma Through Enhancing the Transcription of YBX1 by H3K27Ac Modification. Frontiers in oncology. 2021;11(null):715635.

Freedman ML, Monteiro AN, Gayther SA, Coetzee GA, Risch A, Plass C, et al. Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet. 2011;43(6):513–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun YH, Chou YH, Tsai HY, Hsiao YH, Lee CY, Yang SF, et al. Impact of genetic variants of long noncoding RNA metastasis-Associated Lung Adenocarcinoma transcript 1 on uterine cervical Cancer. J Cancer. 2022;13(7):2150–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeh JC, Chen YT, Chou YE, Su SC, Chang LC, Chen YL, et al. Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer. J Cell Mol Med. 2023;27(21):3395–403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiang X, Chen L, He J, Ma G, Li Y. LncRNA GAS5 rs145204276 polymorphism reduces renal cell Carcinoma susceptibility in Southern Chinese Population. J Inflamm Res. 2022;15(null):1147–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghafouri-Fard S, Dashti S, Taheri M. The HOTTIP (HOXA transcript at the distal tip) lncRNA: Review of oncogenic roles in human. Biomedicine & pharmacotherapy. 2020;127(null):110158.

Wu L, Yang Z, Zhang J, Xie H, Zhou L, Zheng S. Long noncoding RNA HOTTIP expression predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Hepatobiliary Surg Nutr. 2018;7(6):429–39.

Article  PubMed  PubMed Central  Google Scholar 

Wong CH, Li CH, He Q, Chan SL, Tong JH, To KF, et al. Ectopic HOTTIP expression induces noncanonical transactivation pathways to promote growth and invasiveness in pancreatic ductal adenocarcinoma. Cancer Lett. 2020;477(null):1–9.

Article  CAS  PubMed  Google Scholar 

Xin Y, Li X, Zhang M, Shang Z, Luo Z, Wang Y, et al. Fusobacterium nucleatum-induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p/EphB2 axis. Cancer Sci. 2023;114(6):2360–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen M, Li M, Liu J, Long Noncoding RNAHOTTIP. Promotes nasopharyngeal Cancer Cell Proliferation, Migration, and Invasion by inhibiting miR-4301. Med Sci Monitor: Int Med J Experimental Clin Res. 2019;25(null):778–85.

Article  CAS  Google Scholar 

Zhang Y, Wang Y, Jiang Y, Bai H, Wen Y. The meaningful function of the emerging clinical Targets-lncRNA MEG3 in gastric Cancer. Curr Pharm Design. 2023;29(28):2204–12.

Article  CAS  Google Scholar 

Li Y, Zhang L, Zhao Y, Peng H, Zhang N, Bai W. MEG3 sponges miRNA-376a and YBX1 to regulate angiogenesis in ovarian cancer endothelial cells. Heliyon. 2023;9(2):e13204.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Yang H, Xia W, Cui L, Xu R, Lu H, et al. LncRNA MEG3 inhibits the progression of prostate cancer by facilitating H3K27 trimethylation of EN2 through binding to EZH2. J BioChem. 2020;167(3):295–301.

Article  CAS  PubMed  Google Scholar 

Lin L, Liu X, Lv B. Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. J Cell Mol Med. 2021;25(1):61–72.

Article  CAS  PubMed  Google Scholar 

Abdelaleem OO, Shaker OG, AbdelHafez MN, Abdelghaffar NK, Eid HM, Zaidan M, et al. The influence of rs1859168 polymorphism on serum expression of HOTTIP and its target mir-615-3p in Egyptian patients with breast Cancer. Biomolecules. 2021;11(5):null.

Article  Google Scholar 

Wang BG, Li YZ, Ding HX, Lv Z, Xu Q, Yuan Y. HOTTIP polymorphism may affect gastric cancer susceptibility by altering HOTTIP expression. Biosci Rep. 2020;40(8):null.

Article  Google Scholar 

Elhelaly Elsherbeny M, Ramadan Elsergany A, Gamil Shaker O. Association of lncRNA MEG3 Rs7158663 polymorphism and serum expression with colorectal Cancer in Egyptian patients. Rep Biochem Mol Biology. 2023;12(1):102–11.

Google Scholar 

Mohammed SR, Shaker OG, Mohamed MM, Abdelhafez Mostafa MN, Gaber SN, Ali DY, et al. The emerging role of lncRNA MEG3 and MEG3 rs7158663 in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2022;26(1):11–21.

CAS  PubMed  Google Scholar 

Zhang Y, Sun Y, Ma J. Induction gemcitabine and cisplatin in locoregionally advanced nasopharyngeal carcinoma. Cancer Commun (London England). 2019;39(1):39.

Google Scholar 

Liang YL, Zhang Y, Tan XR, Qiao H, Liu SR, Tang LL, et al. A lncRNA signature associated with tumor immune heterogeneity predicts distant metastasis in locoregionally advanced nasopharyngeal carcinoma. Nat Commun. 2022;13(1):2996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Z, Wang YJ, He BS, Zhou J. Linc00312 single nucleotide polymorphism as Biomarker for Chemoradiotherapy Induced Hematotoxicity in Nasopharyngeal Carcinoma patients. Dis Markers. 2022;2022(null):6707821.

Google Scholar 

Guo Z, Li Z, Zhang M, Bao M, He B, Zhou X. LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing. Sci Rep. 2023;13(1):8218.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin C, Wang Y, Wang Y, Zhang S, Yu L, Guo C, et al. Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells. Oncogene. 2017;36(38):5392–406.

Article  CAS  PubMed  Google Scholar 

Han L, Yan Y, Zhao L, Liu Y, Lv X, Zhang L, et al. LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR-148a-3p/WNT1 pathway. J Cell Mol Med. 2020;24(11):6242–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shang A, Wang W, Gu C, Chen C, Zeng B, Yang Y, et al. Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils. J Experimental Clin cancer Research: CR. 2019;38(1):411.

Article  PubMed Central  Google Scholar 

Feng H, Zhao F, Luo J, Xu S, Liang Z, Xu W, et al. Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma. Mol Biol Rep. 2023;50(8):6807–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdi E, Latifi-Navid S, Zahri S, Kholghi-Oskooei V, Mostafaiy B, Yazdanbod A, et al. SNP-SNP interactions of oncogenic long non-coding RNAs HOTAIR and HOTTIP on gastric cancer susceptibility. Sci Rep. 2020;10(1):16763.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali MA, Shaker OG, Ezzat EM, Gaber SN, Hassan EA, Abdelwahed MY, et al. Association between rs1859168/HOTTIP expression level and colorectal Cancer and adenomatous polyposis risk in egyptians. J Interferon Cytokine Res. 2020;40(6):279–91.

Article  CAS  PubMed  Google Scholar 

Duan F, Jiang J, Song C, Wang P, Ye H, Dai L, et al. Functional long non-coding RNAs associated with gastric cancer susceptibility and evaluation of the epidemiological efficacy in a central Chinese population. Gene. 2018;646(null):227–33.

Article