Achberger K, Probst C, Haderspeck J et al (2019) Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform. Elife 8:e46188. https://doi.org/10.7554/eLife.46188

Article  PubMed  PubMed Central  Google Scholar 

Akhtar A (2015) The flaws and human harms of animal experimentation. Camb Q Healthc Ethics 24(4):407–419. https://doi.org/10.1017/S0963180115000079

Article  PubMed  PubMed Central  Google Scholar 

Altmaier S, Meiser I, Lemesre E et al (2022) Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies. Reprod Toxicol 111:68–80. https://doi.org/10.1016/j.reprotox.2022.05.005

Article  CAS  PubMed  Google Scholar 

Artegiani B, Hendriks D, Beumer J et al (2020) Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing. Nat Cell Biol 22(3):321–331. https://doi.org/10.1038/s41556-020-0472-5

Article  CAS  PubMed  Google Scholar 

Astashkina AI, Mann BK, Prestwich GD, Grainger DW (2012a) A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays. Biomaterials 33(18):4700–4711. https://doi.org/10.1016/j.biomaterials.2012.02.063

Article  CAS  PubMed  Google Scholar 

Astashkina AI, Mann BK, Prestwich GD, Grainger DW (2012b) Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines. Biomaterials 33(18):4712–4721. https://doi.org/10.1016/j.biomaterials.2012.03.001

Article  CAS  PubMed  Google Scholar 

Astashkina AI, Jones CF, Thiagarajan G, Kurtzeborn K, Ghandehari H, Brooks BD, Grainger DW (2014) Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model. Biomaterials 35(24):6323–6331. https://doi.org/10.1016/j.biomaterials.2014.04.060

Article  CAS  PubMed  Google Scholar 

Au SH, Chamberlain MD, Mahesh S, Sefton MV, Wheeler AR (2014) Hepatic organoids for microfluidic drug screening. Lab Chip 14(17):3290–3299. https://doi.org/10.1039/c4lc00531g

Article  CAS  PubMed  Google Scholar 

Bassi G, Grimaudo MA, Panseri S, Montesi M (2021) Advanced multi-dimensional cellular models as emerging reality to reproduce in vitro the human body complexity. Int J Mol Sci 22(3):1195. https://doi.org/10.3390/ijms22031195

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beck TC, Arhontoulis DC, Morningstar JE et al (2022) Cellular and molecular mechanisms of MEK1 inhibitor-induced cardiotoxicity. Jacc Cardiooncol 4(4):535–548. https://doi.org/10.1016/j.jaccao.2022.07.009

Article  PubMed  PubMed Central  Google Scholar 

Blakney AK, McKay PF, Hu K et al (2021) Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines. J Control Release 338:201–210. https://doi.org/10.1016/j.jconrel.2021.08.029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boretto M, Cox B, Noben M et al (2017) Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development 144(10):1775–1786. https://doi.org/10.1242/dev.148478

Article  CAS  PubMed  Google Scholar 

Brown T, Ho YS, Gutman SA (2019) High impact and highly cited peer-reviewed journal article publications by canadian occupational therapy authors: a bibliometric analysis. Occup Ther Health Care 33(4):329–354. https://doi.org/10.1080/07380577.2019.1633587

Article  PubMed  Google Scholar 

Brown CN, Atwood D, Pokhrel D et al (2021) Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis 12(3):248. https://doi.org/10.1038/s41419-021-03518-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bu Q, Huang Y, Li M et al (2020) Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids. Food Chem Toxicol 144:111643. https://doi.org/10.1016/j.fct.2020.111643

Article  CAS  PubMed  Google Scholar 

Cakir B, Xiang Y, Tanaka Y et al (2019) Engineering of human brain organoids with a functional vascular-like system. Nat Methods 16(11):1169–1175. https://doi.org/10.1038/s41592-019-0586-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calderon-Gierszal EL, Prins GS (2015) Directed differentiation of human embryonic stem cells into prostate organoids in vitro and its perturbation by low-dose bisphenol a exposure. PLoS ONE 10(7):e133238. https://doi.org/10.1371/journal.pone.0133238

Article  CAS  Google Scholar 

Cao Y, Li S, Chen J (2021) Modeling better in vitro models for the prediction of nanoparticle toxicity: a review. Toxicol Mech Methods 31(1):1–17. https://doi.org/10.1080/15376516.2020.1828521

Article  CAS  PubMed  Google Scholar 

Chaturvedi VK, Singh A, Singh VK, Singh MP (2019) Cancer nanotechnology: a new revolution for cancer diagnosis and therapy. Curr Drug Metab 20(6):416–429. https://doi.org/10.2174/1389200219666180918111528

Article  CAS  PubMed  Google Scholar 

Chen H, Seifikar H, Larocque N, Kim Y, Khatib I, Fernandez CJ, Abello N, Robinson JF (2019) Using a multi-stage hESC model to characterize BDE-47 toxicity during neurogenesis. Toxicol Sci 171(1):221–234. https://doi.org/10.1093/toxsci/kfz136

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Lu N, Huang S, Zhang Y, Liu Z, Wang X (2023) Assessment of doxorubicin toxicity using human cardiac organoids: a novel model for evaluating drug cardiotoxicity. Chem Biol Interact 386:110777. https://doi.org/10.1016/j.cbi.2023.110777

Article  CAS  PubMed  Google Scholar 

Choi Y, Park K, Kim I, Kim SD (2018) Combined toxic effect of airborne heavy metals on human lung cell line A549. Environ Geochem Health 40(1):271–282. https://doi.org/10.1007/s10653-016-9901-6

Article  CAS  PubMed  Google Scholar 

Clark CC, Yoo KM, Sivakumar H, Strumpf K, Laxton AW, Tatter SB, Strowd RE, Skardal A (2022) Immersion bioprinting of hyaluronan and collagen bioink-supported 3D patient-derived brain tumor organoids. Biomed Mater 18(1):10. https://doi.org/10.1088/1748-605X/aca05d

Article  Google Scholar 

Clinton JW, Kiparizoska S, Aggarwal S, Woo S, Davis W, Lewis JH (2021) Drug-induced liver injury: highlights and controversies in the recent literature. Drug Saf 44(11):1125–1149. https://doi.org/10.1007/s40264-021-01109-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colacino JA, McDermott SP, Sartor MA, Wicha MS, Rozek LS (2016) Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. Breast Cancer Res Treat 158(1):29–41. https://doi.org/10.1007/s10549-016-38544

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crespo M, Vilar E, Tsai SY et al (2017) Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nat Med 23(7):878–884. https://doi.org/10.1038/nm.4355

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crespo M, Vilar E, Tsai SY et al (2018) Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nat Med 24(4):526. https://doi.org/10.1038/nm0418-526a

Article  CAS