Heparin-induced thrombocytopenia with very high antibody titer is associated with slower platelet recovery and higher risk of thrombosis

Warkentin TE, Sheppard JI, Moore JC, Sigouin CS, Kelton JG. Quantitative interpretation of optical density measurements using PF4-dependent enzyme-immunoassays. J Thromb Haemost. 2008;6(8):1304–12.

Article  CAS  PubMed  Google Scholar 

Warkentin TE, Sheppard JAI. Testing for heparin-induced thrombocytopenia antibodies. Transfus Med Rev. 2006;20(4):259–72.

Article  PubMed  Google Scholar 

Zwicker JI, Uhl L, Huang WY, Shaz BH, Bauer KA. Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2004;2(12):2133–7.

Article  CAS  PubMed  Google Scholar 

Wallis DE, Workman DL, Lewis BE, Steen L, Pifarre R, Moran JF. Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia. Am J Med. 1999;106(6):629–35.

Article  CAS  PubMed  Google Scholar 

Rice L. Cases of heparin-induced thrombocytopenia elucidate the syndrome. Chest. 2005;127(2):21S-26S.

Article  PubMed  Google Scholar 

Visentin GP, Moghaddam M, Beery SE, McFarland JG, Aster RH. Heparin is not required for detection of antibodies associated with heparin-induced thrombocytopenia/thrombosis. J Lab Clin Med. 2001;138(1):22–31.

Article  CAS  PubMed  Google Scholar 

Eichler P, Raschke R, Lubenow N, Meyer O, Schwind P, Greinacher A. The new ID-heparin/PF4 antibody test for rapid detection of heparin-induced antibodies in comparison with functional and antigenic assays: ID-heparin/PF4 antibody test for detection of HIT antibodies. Br J Haematol. 2002;116(4):887–91.

Article  CAS  PubMed  Google Scholar 

Legnani C, Cini M, Pili C, Boggian O, Frascaro M, Palareti G. Evaluation of a new automated panel of assays for the detection of anti-PF4/heparin antibodies in patients suspected of having heparin-induced thrombocytopenia. Thromb Haemost. 2010;104(08):402–9.

Article  CAS  PubMed  Google Scholar 

Juhl D, Eichler P, Lubenow N, Strobel U, Wessel A, Greinacher A. Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. Eur J Haematol. 2006;76(5):420–6.

Article  PubMed  Google Scholar 

Francis J. A critical evaluation of assays for detecting antibodies to the heparin-PF4 complex. Semin Thromb Hemost. 2004;30(03):359–68.

Article  CAS  PubMed  Google Scholar 

Padmanabhan A, Jones C, Curtis BR, Bougie DW, Sullivan M, Peswani N, et al. A novel PF4-dependent platelet activation assay identifies patients likely to have heparin-induced thrombocytopenia/thrombosis (HIT). Blood. 2015;126(23):764–764.

Article  Google Scholar 

Marchetti M, Zermatten MG, Bertaggia Calderara D, Aliotta A, Alberio L. Heparin-induced thrombocytopenia: a review of new concepts in pathogenesis, diagnosis, and management. J Clin Med. 2021;10(4):683.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greinacher A. Heparin-induced thrombocytopenia. Solomon CG, editor. N Engl J Med. 2015;373(3):252–61.

Article  CAS  PubMed  Google Scholar 

Warkentin TE, Anderson JAM. How I treat patients with a history of heparin-induced thrombocytopenia. Blood. 2016;128(3):348–59.

Article  CAS  PubMed  Google Scholar 

Arepally GM, Ortel TL. Heparin-induced thrombocytopenia. Annu Rev Med. 2010;61(1):77–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cuker A, Cines DB. How I treat heparin-induced thrombocytopenia. Blood. 2012;119(10):2209–18.

Article  CAS  PubMed  Google Scholar 

Thorevska N, Amoateng-Adjepong Y, Sabahi R, Schiopescu I, Salloum A, Muralidharan V, et al. Anticoagulation in hospitalized patients with renal insufficiency. Chest. 2004;125(3):856–63.

Article  CAS  PubMed  Google Scholar 

Hughes S, Szeki I, Nash MJ, Thachil J. Anticoagulation in chronic kidney disease patients—the practical aspects. Clin Kidney J. 2014;7(5):442–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Warkentin TE, Pai M, Linkins LA. Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review. Blood. 2017;130(9):1104–13.

Article  CAS  PubMed  Google Scholar 

Tardy-Poncet B, Piot M, Montmartin A, Burdier A, Chalayer E, Tardy B. Delayed-onset heparin-induced thrombocytopenia without thrombosis in a patient receiving postoperative thromboprophylaxis with rivaroxaban. Thromb Haemost. 2015;114(09):652–4.

Article  PubMed  Google Scholar 

Linkins LA, Warkentin TE, Pai M, Shivakumar S, Manji RA, Wells PS, et al. Rivaroxaban for treatment of suspected or confirmed heparin-induced thrombocytopenia study. J Thromb Haemost. 2016;14(6):1206–10.

Article  CAS  PubMed  Google Scholar 

Sharifi M, Bay C, Vajo Z, Freeman W, Sharifi M, Schwartz F. New oral anticoagulants in the treatment of heparin-induced thrombocytopenia. Thromb Res. 2015;135(4):607–9.

Article  CAS  PubMed  Google Scholar 

Larsen PB, Jørgensen M, Friis-Hansen L, Ingeberg S. Apixaban used for the management of heparin-induced thrombocytopenia in a 72-year-old woman with lung cancer. Clin Case Rep. 2015;3(12):987–9.

Article  PubMed  PubMed Central  Google Scholar 

Delgado-García G, Monreal-Robles R. Acute apixaban treatment of heparin-induced thrombocytopenia. J Thromb Thrombolysis. 2017;43(3):289–90.

Article  PubMed  Google Scholar 

Anniccherico FJ, Alonso JL. Dabigatran for heparin-induced thrombocytopenia. Mayo Clin Proc. 2013;88(9):1036.

Article  PubMed  Google Scholar 

Noel E, Abbas N, Skaradinskiy Y, Schreiber Z. Heparin-induced thrombocytopenia in a patient with essential thrombocythemia: a case based update. Case Rep Hematol. 2015;2015:1–5.

Article  Google Scholar 

Cuker A, Arepally GM, Chong BH, Cines DB, Greinacher A, Gruel Y, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia. Blood Adv. 2018;2(22):3360–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Altuntas F, Matevosyan K, Burner J, Shen YM, Sarode R. Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia. Eur J Haematol. 2008;80(5):429–35.

Article  PubMed  Google Scholar 

Baroletti S, Hurwitz S, Conti NAS, Fanikos J, Piazza G, Goldhaber SZ. Thrombosis in suspected heparin-induced thrombocytopenia occurs more often with high antibody levels. Am J Med. 2012;125(1):44–9.

Article  CAS  PubMed  Google Scholar 

Warkentin T, Hayward C, Boshkov L, Santos A, Sheppard J, Bode A, et al. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood. 1994;84(11):3691–9.

Article  CAS  PubMed  Google Scholar 

Arman M, Krauel K. Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis. J Thromb Haemost. 2015;13(6):893–908.

Article  CAS  PubMed  Google Scholar

留言 (0)

沒有登入
gif