Nucleus accumbens ghrelin signaling controls anxiety-like behavioral response to acute stress

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–60.

Article  CAS  PubMed  Google Scholar 

Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG. Van Der Ploeg LH. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273:974–7.

Article  CAS  PubMed  Google Scholar 

Mani BK, Walker AK, Lopez Soto EJ, Raingo J, Lee CE, Perello M, Andrews ZB, Zigman JM. Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse. J Comp Neurol. 2014;522:3644–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alvarez-Crespo M, Skibicka KP, Farkas I, Molnar CS, Egecioglu E, Hrabovszky E, Liposits Z, Dickson SL. The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence. PLoS ONE. 2012;7:e46321.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spencer SJ, Xu L, Clarke MA, Lemus M, Reichenbach A, Geenen B, Kozicz T, Andrews ZB. Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress. Biol Psychiatry. 2012;72:457–65.

Article  CAS  PubMed  Google Scholar 

Muller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D’Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Dieguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrere B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschop MH. Ghrelin. Mol Metab. 2015;4:437–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fritz EM, Singewald N, De Bundel D. The Good, the bad and the unknown aspects of ghrelin in stress coping and stress-related Psychiatric disorders. Front Synaptic Neurosci. 2020;12:594484.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chovel Sella A, Hadaway N, Stern C, Becker KR, Holsen LM, Eddy KT, Micali N, Misra M, Thomas JJ, Lawson EA. Lower ghrelin levels are Associated with higher anxiety symptoms in adolescents and young adults with Avoidant/Restrictive food intake disorder. J Clin Psychiatry. 2023;84.

Kristensson E, Sundqvist M, Hakanson R, Lindstrom E. High gastrin cell activity and low ghrelin cell activity in high-anxiety Wistar Kyoto rats. J Endocrinol. 2007;193:245–50.

Article  CAS  PubMed  Google Scholar 

Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, Birnbaum S, Yanagisawa M, Elmquist JK, Nestler EJ, Zigman JM. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci. 2008;11:752–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Niu M, Qiu X, Cao H, Xing B, Sun Y, Zhou Z, Zhou Y. Acute but not chronic calorie restriction defends against stress-related anxiety and despair in a GHS-R1a-Dependent manner. Neuroscience. 2019;412:94–104.

Article  CAS  PubMed  Google Scholar 

Chuang JC, Zigman JM. Ghrelin’s Roles in Stress, Mood, and Anxiety Regulation. Int J Pept. 2010;2010.

Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, Katsuura G, Makino S, Fujino MA, Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology. 2001;74:143–7.

Article  CAS  PubMed  Google Scholar 

Carlini VP, Monzon ME, Varas MM, Cragnolini AB, Schioth HB, Scimonelli TN, de Barioglio SR. Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun. 2002;299:739–43.

Article  CAS  PubMed  Google Scholar 

Currie PJ, Khelemsky R, Rigsbee EM, Dono LM, Coiro CD, Chapman CD, Hinchcliff K. Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus. Behav Brain Res. 2012;226:96–105.

Article  CAS  PubMed  Google Scholar 

Hansson C, Haage D, Taube M, Egecioglu E, Salome N, Dickson SL. Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence. Neuroscience. 2011;180:201–11.

Article  CAS  PubMed  Google Scholar 

Bewernick BH, Hurlemann R, Matusch A, Kayser S, Grubert C, Hadrysiewicz B, Axmacher N, Lemke M, Cooper-Mahkorn D, Cohen MX, Brockmann H, Lenartz D, Sturm V, Schlaepfer TE. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biol Psychiatry. 2010;67:110–6.

Article  PubMed  Google Scholar 

Salamone JD, Cousins MS, Snyder BJ. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev. 1997;21:341–59.

Article  CAS  PubMed  Google Scholar 

Shirayama Y, Chaki S. Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. Curr Neuropharmacol. 2006;4:277–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zarrindast MR, Babapoor-Farrokhran S, Babapoor-Farrokhran S, Rezayof A. Involvement of opioidergic system of the ventral hippocampus, the nucleus accumbens or the central amygdala in anxiety-related behavior. Life Sci. 2008;82:1175–81.

Article  CAS  PubMed  Google Scholar 

Meredith GE. The synaptic framework for chemical signaling in nucleus accumbens. Ann N Y Acad Sci. 1999;877:140–56.

Article  CAS  PubMed  Google Scholar 

Lim LW, Prickaerts J, Huguet G, Kadar E, Hartung H, Sharp T, Temel Y. Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms. Transl Psychiatry. 2015;5:e535.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kabli N, Nguyen T, Balboni G, O’Dowd BF, George SR. Antidepressant-like and anxiolytic-like effects following activation of the mu-delta opioid receptor heteromer in the nucleus accumbens. Mol Psychiatry. 2014;19:986–94.

Article  CAS  PubMed  Google Scholar 

Gawande DY, Shelkar GP, Liu J, Ayala AD, Pavuluri R, Choi D, Smith Y, Dravid SM. Glutamate Delta-1 receptor regulates inhibitory neurotransmission in the Nucleus Accumbens Core and anxiety-like behaviors. Mol Neurobiol. 2021;58:4787–801.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sustkova-Fiserova M, Charalambous C, Havlickova T, Lapka M, Jerabek P, Puskina N, Syslova K. Alterations in rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: the role of Ghrelin. Int J Mol Sci. 2017;18.

Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 7th ed. San Diego, CA: Academic; 2014.

Google Scholar 

Zhang XY, Peng SY, Shen LP, Zhuang QX, Li B, Xie ST, Li QX, Shi MR, Ma TY, Zhang Q, Wang JJ, Zhu JN. Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors. Proc Natl Acad Sci U S A. 2020;117:32155–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhuang QX, Li GY, Li B, Zhang CZ, Zhang XY, Xi K, Li HZ, Wang JJ, Zhu JN. Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits. J Clin Invest. 2018;128:5413–27.

Article  PubMed  PubMed Central  Google Scholar 

Li B, Chang L, Zhuang QX. Histamine signaling in the bed nucleus of the stria terminalis modulates stress-induced anxiety. J Affect Disord. 2023;335:195–203.

Article  CAS  PubMed  Google Scholar 

Li L, Zhang LK, Pang YZ, Pan CS, Qi YF, Chen L, Wang X, Tang CS, Zhang J. Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. Acta Pharmacol Sin. 2006;27:527–35.

Article  PubMed 

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