TGF-β1-Induced LINC01094 promotes epithelial-mesenchymal transition in hepatocellular carcinoma through the miR-122-5p/TGFBR2–SAMD2–SMAD3 Axis

Carlevaro-Fita J, Lanzos A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS, Drivers P, Functional Interpretation G, Johnson R, Consortium P (2020) Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol 3(1):56

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S et al (2019) DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. J Exp Clin Cancer Res 38(1):273

Article  PubMed  PubMed Central  Google Scholar 

Chen T, Liu R, Niu Y, Mo H, Wang H, Lu Y, Wang L, Sun L, Wang Y, Tu K et al (2021a) HIF-1alpha-activated long non-coding RNA KDM4A-AS1 promotes hepatocellular carcinoma progression via the miR-411-5p/KPNA2/AKT pathway. Cell Death Dis 12(12):1152

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen T, Huang B, Pan Y (2021b) Long non-coding RNA MAFG-AS1 promotes cell proliferation, Migration, and EMT by miR-3196/STRN4 in drug-resistant cells of Liver Cancer. Front Cell Dev Biol 9:688603

Article  PubMed  PubMed Central  Google Scholar 

Dongre A, Weinberg RA (2019) New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol 20(2):69–84

Article  CAS  PubMed  Google Scholar 

Engreitz JM, Ollikainen N, Guttman M (2016) Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression. Nat Rev Mol Cell Biol 17(12):756–770

Article  CAS  PubMed  Google Scholar 

Forner A, Reig M, Bruix J (2018) Hepatocellular carcinoma. Lancet 391(10127):1301–1314

Article  PubMed  Google Scholar 

Gao J, Yin X, Yu X, Dai C, Zhou F (2019) Long noncoding LINC01551 promotes hepatocellular carcinoma cell proliferation, migration, and invasion by acting as a competing endogenous RNA of microRNA-122-5p to regulate ADAM10 expression. J Cell Biochem 120(10):16393–16407

Article  CAS  PubMed  Google Scholar 

Gutschner T, Diederichs S (2012) The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol 9(6):703–719

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han M, Liao Z, Liu F, Chen X, Zhang B (2020a) Modulation of the TGF-beta signaling pathway by long noncoding RNA in hepatocellular carcinoma. Biomark Res 8(1):70

Article  PubMed  PubMed Central  Google Scholar 

Han T-S, Hur K, Cho H-S, Ban HS (2020b) Epigenetic associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma. Cancers 12(9)

Huang X, Pan L, Zuo Z, Li M, Zeng L, Li R, Ye Y, Zhang J, Wu G, Bai R et al (2021) LINC00842 inactivates transcription co-regulator PGC-1alpha to promote pancreatic cancer malignancy through metabolic remodelling. Nat Commun 12(1):3830

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jayachandran A, Dhungel B, Steel JC (2016) Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma. J Hematol Oncol 9(1)

Jiang Y, Li W, Yan Y, Yao X, Gu W, Zhang H (2020) LINC01094 triggers radio-resistance in clear cell renal cell carcinoma via miR-577/CHEK2/FOXM1 axis. Cancer Cell Int 20:274

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kopp F, Mendell JT (2018) Functional classification and experimental dissection of long noncoding RNAs. Cell 172(3):393–407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lai S, Quan Z, Hao Y, Liu J, Wang Z, Dai L, Dai H, He S, Tang B (2021) Long non-coding RNA LINC01572 promotes Hepatocellular Carcinoma Progression via sponging mir-195-5p to Enhance PFKFB4-Mediated glycolysis and PI3K/AKT activation. Front Cell Dev Biol 9:783088

Article  PubMed  PubMed Central  Google Scholar 

Li XX, Yu Q (2020) Linc01094 accelerates the growth and metastatic-related traits of Glioblastoma by sponging miR-126-5p. Onco Targets Ther 13:9917–9928

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang H, Yu T, Han Y, Jiang H, Wang C, You T, Zhao X, Shan H, Yang R, Yang L et al (2018) LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding mir-101-3p to regulate ZEB1 expression. Mol Cancer 17(1):119

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Wang Y, Fu X, Lu Z (2018) Long non-coding RNA NEAT1 promoted ovarian cancer cells’ metastasis through regulation of miR-382-3p/ROCK1 axial. Cancer Sci 109(7):2188–2198

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu W, Zhang H, Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H et al (2017) Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. Mol Cancer 16(1):118

Article  PubMed  PubMed Central  Google Scholar 

Ma J, Li T, Han X, Yuan H (2018) Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating mir-122-5p expression in hepatocellular carcinoma. J Cancer Res Clin Oncol 144(2):205–214

Article  CAS  PubMed  Google Scholar 

Moon HSaA (2010) Epithelial-mesenchymal transition and cell Invasion. Toxicol Res 26(4):245–252

Article  Google Scholar 

Nieto MA, Huang RY, Jackson RA, Thiery JP (2016) Emt: 2016. Cell 166(1):21–45

Article  CAS  PubMed  Google Scholar 

Sardina DS, Alaimo S, Ferro A, Pulvirenti A, Giugno R (2017) A novel computational method for inferring competing endogenous interactions. Brief Bioinform 18(6):1071–1081

CAS  PubMed  Google Scholar 

Schmitt AM, Chang HY (2016) Long noncoding RNAs in Cancer pathways. Cancer Cell 29(4):452–463

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249

Article  PubMed  Google Scholar 

Wan Y, Li M, Huang P (2019) LINC01296 promotes proliferation, migration, and invasion of HCC cells by targeting mir-122-5P and modulating EMT activity. Onco Targets Ther 12:2193–2203

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang N, Wang Q, Shen D, Sun X, Cao X, Wu D (2016) Downregulation of microRNA-122 promotes proliferation, migration, and invasion of human hepatocellular carcinoma cells by activating epithelial-mesenchymal transition. Onco Targets Ther 9:2035–2047

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Liu Z, Yao B, Li Q, Wang L, Wang C, Dou C, Xu M, Liu Q, Tu K (2017) Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis. Mol Cancer 16(1):123

Article  PubMed  PubMed Central  Google Scholar 

Guo W, Wang Y, Yang M, Wang Z, Wang Y, Chaurasia S, Wu Z, Zhang M, Yadav GS, Rathod S et al (2021) LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance. Sci Adv 7(7):eabb3555

Wu N, Jiang M, Liu H, Chu Y, Wang D, Cao J, Wang Z, Xie X, Han Y, Xu B (2021) LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-beta/SMAD2/3 signaling pathway. Cell Death Differ 28(1):219–232

Article  CAS  PubMed  Google Scholar 

Xu J, Zhang P, Sun H, Liu Y (2020) LINC01094/miR-577 axis regulates the progression of ovarian cancer. J Ovarian Res 13(1):122

Article  CAS 

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